Guanine quadruplexes and their roles in molecular processes

Mishra, Shruti; Kota, Swathi; Chaudhary, Reema; Misra, Hari S.

doi:10.1080/10409238.2021.1926417

Cited by 5 publications

(5 citation statements)

References 169 publications

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“…10 The study on the emerging roles of G4s in mitochondria has been discussed comprehensively in recent reviews. 11,149 Although several fluorescent probes selectively recognizing and imaging mtDNA G4s have 126 The integration of a rotatable terminal amino group to 1-methylquinolinium results in high selectivity toward G4-DNA substrates. Adapted with permission from ref.…”

Section: G4-selective Fluorescent Ligands For Molecular Recognition A...mentioning

confidence: 99%

“…10 The study on the emerging roles of G4s in mitochondria has been discussed comprehensively in recent reviews. 11,149 Although several fluorescent probes selectively recognizing and imaging mtDNA G4s have been reported, compared to nuclear DNA G4s, the ligand system developed thus far is very limited. The reported fluorescent ligands with high selectivity toward mtDNA G4s against other types of G4s and nucleic acid structures are summarized in Fig.…”

Section: G4-selective Fluorescent Ligands For Molecular Recognition A...mentioning

confidence: 99%

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Structurally diverse G-quadruplexes as the noncanonical nucleic acid drug target for live cell imaging and antibacterial study

Zheng

Long

et al. 2023

Chem. Commun.

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Section: G4-selective Fluorescent Ligands For Molecular Recognition A...mentioning

confidence: 99%

“…10 The study on the emerging roles of G4s in mitochondria has been discussed comprehensively in recent reviews. 11,149 Although several fluorescent probes selectively recognizing and imaging mtDNA G4s have been reported, compared to nuclear DNA G4s, the ligand system developed thus far is very limited. The reported fluorescent ligands with high selectivity toward mtDNA G4s against other types of G4s and nucleic acid structures are summarized in Fig.…”

Section: G4-selective Fluorescent Ligands For Molecular Recognition A...mentioning

confidence: 99%

Structurally diverse G-quadruplexes as the noncanonical nucleic acid drug target for live cell imaging and antibacterial study

Zheng

Long

et al. 2023

Chem. Commun.

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“…The cationic H 2 TMPyP is one of the most studied porphyrins in telomerase inhibition by adduct formation with telomeric GQ structures [38,56,60], and in the stabilization of non-telomeric biologically relevant GQs from human oncopromoters, bacterial genomes and viral genomes [8].…”

Section: Porphyrins and Metalloporphyrins As Interactive G-quadruplex Ligandsmentioning

confidence: 99%

“…Other important targets for anti-cancer drug design are human oncogene suppressor genes due to their close association with the appearance of cancer genes can result from the mutation of proto-oncogenes, the genes responsibl cell division, stimulation and death. Therefore, oncogenes involved in the in progression of tumors have also been recognized as targets for the developm anticancer drugs [7,8]. An interesting discussion concerning the challenges a advantages of targeting telomeric G-quadruplex (GQ) compared to gen G-quadruplexes and to protein or enzyme targets was reported by Balasubra [7].…”

Section: Introductionmentioning

confidence: 99%

The Interactions of H2TMPyP, Analogues and Its Metal Complexes with DNA G-Quadruplexes—An Overview

et al. 2021

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The evidence that telomerase is overexpressed in almost 90% of human cancers justifies the proposal of this enzyme as a potential target for anticancer drug design. The inhibition of telomerase by quadruplex stabilizing ligands is being considered a useful approach in anticancer drug design proposals. Several aromatic ligands, including porphyrins, were exploited for telomerase inhibition by adduct formation with G-Quadruplex (GQ). 5,10,15,20-Tetrakis(N-methyl-4-pyridinium)porphyrin (H2TMPyP) is one of the most studied porphyrins in this field, and although reported as presenting high affinity to GQ, its poor selectivity for GQ over duplex structures is recognized. To increase the desired selectivity, porphyrin modifications either at the peripheral positions or at the inner core through the coordination with different metals have been handled. Herein, studies involving the interactions of TMPyP and analogs with different DNA sequences able to form GQ and duplex structures using different experimental conditions and approaches are reviewed. Some considerations concerning the structural diversity and recognition modes of G-Quadruplexes will be presented first to facilitate the comprehension of the studies reviewed. Additionally, considering the diversity of experimental conditions reported, we decided to complement this review with a screening where the behavior of H2TMPyP and of some of the reviewed metal complexes were evaluated under the same experimental conditions and using the same DNA sequences. In this comparison under unified conditions, we also evaluated, for the first time, the behavior of the AgII complex of H2TMPyP. In general, all derivatives showed good affinity for GQ DNA structures with binding constants in the range of 106–107 M−1 and ligand-GQ stoichiometric ratios of 3:1 and 4:1. A promising pattern of selectivity was also identified for the new AgII derivative.

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“…Since telomerase cannot recognize G-quadruplex as substrates [19], the indirect targeting of this enzyme, by the stabilisation of G4 DNA secondary structures with ligands, can be considered a promising strategy [20][21][22][23]; this stabilisation could ensure the telomeres configuration in the quadruplex arrangement inhibiting telomerase function and telomere lengthening. A similar strategy could also be used to inhibit oncogenes expression and, as a consequence, to compromise the transcription process [12,[24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

opp-Dibenzoporphyrin Pyridinium Derivatives as Potential G-Quadruplex DNA Ligands

Moura,

Cavaleiro,

Neves

et al. 2023

Molecules

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Since the occurrence of tumours is closely associated with the telomerase function and oncogene expression, the structure of such enzymes and genes are being recognized as targets for new anticancer drugs. The efficacy of several ligands in telomerase inhibition and in the regulation of genes expression, by an effective stabilisation of G-quadruplexes (G4) DNA structures, is being considered as a promising strategy in cancer therapies. When evaluating the potential of a ligand for telomerase inhibition, the selectivity towards quadruplex versus duplex DNA is a fundamental attribute due to the large amount of double-stranded DNA in the cellular nucleus. This study reports the evaluated efficacy of three tetracationic opp-dibenzoporphyrins, a free base, and the corresponding zinc(II) and nickel(II) complexes, to stabilise G4 structures, namely the telomeric DNA sequence (AG3(T2AG3)3). In order to evaluate the selectivity of these ligands towards G4 structures, their interaction towards DNA calf thymus, as a double-strand DNA sequence, were also studied. The data obtained by using different spectroscopic techniques, such as ultraviolet-visible, fluorescence, and circular dichroism, suggested good affinity of the free-base porphyrin and of its zinc(II) complex for the considered DNA structures, both showing a pattern of selectivity for the telomeric G4 structure. A pattern of aggregation in aqueous solution was detected for both Zn(II) and Ni(II) metallo dibenzoporphyrins and the ability of DNA sequences to induce ligand disaggregation was observed.

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Guanine quadruplexes and their roles in molecular processes

Cited by 5 publications

References 169 publications

Structurally diverse G-quadruplexes as the noncanonical nucleic acid drug target for live cell imaging and antibacterial study

Structurally diverse G-quadruplexes as the noncanonical nucleic acid drug target for live cell imaging and antibacterial study

The Interactions of H2TMPyP, Analogues and Its Metal Complexes with DNA G-Quadruplexes—An Overview

opp-Dibenzoporphyrin Pyridinium Derivatives as Potential G-Quadruplex DNA Ligands

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