Guanine nucleotide-binding protein subunit beta-2-like 1, a new Annexin A7 interacting protein

Inhibition of annexin A7 gene and protein induces the apotosis and decreases the invasion, migration of the hepatocarcinoma cell line

“…These results indicated that ANXA7 could promote proliferation, and increase migration and invasion in mouse hepatocarcinoma cell line. The downregulating ANXA7 in the gene level by RNAi technique has been confirmed by our previous studies [4][5][6][7]9]. In this study, we showed a decreased expression of ANXA7 by using anti-ANXA7 antibody in the protein level.…”

“…Our previous studies have also indicated that 33 genes, such as ANXA7, Sorcin, Gelsolin showed different expressions in both gene and protein levels in Hca-F and Hca-P cell lines [2][3][4][5][6][7][8][9].…”

“…A couple of cell lines with different lymphatic metastatic potentials, Hca-F cell line (lymphatic metastasis rate > 70%) and Hca-P cell line (lymphatic metastasis rate < 30%) have been set up in our lab from hepatocarcinoma in the mouse and have been proved to be ideal models for studying hepatocarcinoma lymphatic metastasis as described in our lab [2][3][4][5][6][7][8][9]. Our previous studies have also indicated that 33 genes, such as ANXA7, Sorcin, Gelsolin showed different expressions in both gene and protein levels in Hca-F and Hca-P cell lines [2][3][4][5][6][7][8][9].…”

RETRACTED: Annexin A7 modulates BAG4 and BAG4-binding proteins in mitochondrial apoptosis

“…For 12 example, Annexin A7 formed a complex with RACK1 in mouse 13 hepatocarcinoma cells. RACK1-Annexin A7 complex had a positive 14 effects on potentials of metastasis [1]. Furthermore, Annexin A7 15 binded the binder of Arl two (BART) in pancreatic cancer cells.…”

Diverse Roles of Annexin A6 in Triple-Negative Breast Cancer Diagnosis, Prognosis and EGFR-Targeted Therapies

“…This appears to occur via a nucleotide-binding domain located in the N-terminus of nucleotide-sensitive annexins [ 46 ]. While the molecular details still remain sparse, the interaction may occur directly [ 48 ] or in the case of AnxA7, via bona fide nucleotide-binding proteins such as guanine nucleotide-binding protein subunit beta-2-like 1 (also known as the receptor for activated C kinase 1 (RACK1)) [ 49 ]. Earlier studies on the interaction of AnxA6 with nucleotides suggested the existence of two AnxA6 domains within residues 293-301 and 641-649 that potentially bind the phosphate groups of GTP [ 48 ].…”