Guanidino compounds generate reactive oxygen species

Mori, Akitane; Kohno, Masahiro; Masumizu, Toshiki; Noda, Yasuko; Packer, Lester

doi:10.1080/15216549600201622

Cited by 34 publications

(35 citation statements)

References 19 publications

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“…GAA induces oxidative stress after experimental intrastriatal infusion (Zugno et al 2008), or excessive accumulation in pathological conditions (Mori et al 1996), while dietary GAA improves antioxidant status by elevating total antioxidant capacity and the activities of several antioxidant enzymes (Wang et al 2012). Contrasting results of the previous studies are accompanied with different levels of GAA achieved after GAA administration/accumulation.…”

Section: Antioxidant Capacity and Enzyme Activitycontrasting

confidence: 53%

Effects of dietary guanidinoacetic acid and betaine supplementation on performance, blood biochemical parameters and antioxidant status of broilers subjected to cold stress

Nasiroleslami

Torki

Saki

et al. 2018

Journal of Applied Animal Research

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This study was conducted to determine the effects of dietary guanidinoacetic acid (GAA) and betaine supplementation on performance, antioxidant status and biochemical parameters of broilers subjected to cold stress. Based on a 2 × 2 factorial arrangement, 384-day-old male broiler chicks (Cobb) were randomly distributed between four experimental diets (with 8 replicates and 12 birds per replicate) included basal diet (as control) and the basal diet supplemented with 1200 mg/kg GAA; 600 mg/kg betaine and 1200 mg/kg GAA + 600 mg/kg betaine. No significant dietary effects were seen on performance, haematological and blood biochemical parameters including plasma glucose, uric acid, total antioxidant status, lactate, lactate dehydrogenase, red blood cell, haemoglobin, haematocrit and heterophil-to-lymphocyte ratios. However, malondialdehyde (MDA), and the activity of creatine kinase (CK), superoxide dismutase (SOD) and glutathione peroxidase (GPx) were affected by the experimental diets. Compared with the other groups, betaine supplementation decreased liver MDA level and SOD activity while increased activity of liver GPx and serum CK and decreased serum level of MDA were observed in birds fed the GAA-included diet. Overall, based on the results, it seems that dietary GAA and betaine could have beneficial effects on antioxidant status of broilers subjected to cold stress. ARTICLE HISTORY

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Section: Antioxidant Capacity and Enzyme Activitycontrasting

confidence: 53%

Effects of dietary guanidinoacetic acid and betaine supplementation on performance, blood biochemical parameters and antioxidant status of broilers subjected to cold stress

Nasiroleslami

Torki

Saki

et al. 2018

Journal of Applied Animal Research

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“…This observation suggests that dietary GAA has oxidant-antioxidant capacity (Ostogic et al, 2015). It has been shown that high levels of GAA could stimulate the generation of reactive oxygen species in the body (Mori et al, 1996), decrease non-enzymatic antioxidant capacity, and increase lipid peroxidation in rats (Zugno et al, 2008). This is observed as a higher heterophils to lymphocytes ratio (H:L) in birds fed GAA at 2 g/kg than in those fed with lower levels of GAA supplementation.…”

Section: Discussionmentioning

confidence: 56%

Growth Performance and Right Ventricular Hypertrophy Responses of Broiler Chickens to Guanidinoacetic Acid Supplementation under Hypobaric Hypoxia

et al. 2018

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Guanidinoacetic acid (GAA) has been shown to spare arginine (ARG) requirements in chickens. ARG plays a critical role in enhancing growth and preventing right ventricular hypertrophy (RVH) in broiler chickens subjected to hypobaric hypoxia. However, ARG is not available as a feed grade supplement in the market. Therefore, we evaluated the effects of commercially available GAA supplement as an alternative on growth performance and RVH in broilers raised at high altitude (2100 m). Five graded levels of GAA ranging from 0 (control) to 2 g/kg were provided in isoenergetic and isonitrogenous diets to broilers (Ross 308) from day 1 to 42, post-hatch. Results indicated that responses to GAA were nonlinear and attained plateau values within the studied range of GAA supply. While weight gain and feed intake were unaffected by GAA supply, feed conversion ratio was improved by GAA supplementation up to 1.5 g/kg. Similar trends were observed for the proportions in the liver and heart, as well as hematocrit. GAA supplementation at 1 and 1.5 g/kg resulted in reduced abdominal fat deposition as well as a decline in right-tototal ventricular weight ratio (RV:TV, an index of RVH). A significant (P＜0.05) increase in serum nitric oxide concentration was observed at 1 and 1.5 g/kg GAA supplementation. However, GAA supply led to lower serum malondialdehyde and uric acid levels than in the control. In conclusion, GAA supplementation up to 1.5 g/kg had the potential to improve growth performance and RVH response. Meanwhile, GAA supply beyond 1.5 g/kg could deteriorate these responses.

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“…An increase in oxidants has been found in patients with end-stage renal diseases on chronic hemodialysis (CHD) [1,2]. Several reports indicated that CHD patients have higher plasma concentrations of lipid peroxide [3][4][5] and oxidation protein products [6,7] with a decrease in plasma antioxidants [3,8,9].…”

Section: Introductionmentioning

confidence: 99%

Increase in Resting Levels of Superoxide Anion in the Whole Blood of Uremic Patients on Chronic Hemodialysis

Chen¹,

Chang²,

Liou³

1998

Blood Purif

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Recently, we developed a new method to measure the resting level of superoxide anion in whole blood using an ultrasensitive chemiluminescence analyzer and lucigenin amplification. The advantage of this method is that the assay system can be performed in the absence of leukocyte isolation and stimulant administration. In this study, we applied this method to measure the blood resting levels of superoxide anion in 104 uremic patients on chronic hemodialysis (CHD) and 98 sex- and age-matched healthy controls to clarify the influence of HD on blood levels of superoxide anion. Simultaneously, the plasma levels of copper, zinc superoxide dismutase (Cu,Zn-SOD), glutathion peroxidase (GPX), myeloperoxidase (MPO) and lactoferrin (Lacto-F) were measured. The results showed that the basal blood levels of superoxide anion, Cu,Zn-SOD, and MPO in CHD patients were significantly greater than those of healthy controls. However, there was no difference in the basal plasma levels of Lacto-F and GPX between CHD patients and healthy controls. One session of HD further increased the blood levels of superoxide anion, MPO, Lacto-F and Cu,Zn-SOD but not GPX. These results suggest that the blood levels of superoxide anion are higher in CHD patients and further increase after one session of HD. This mechanism should be studied further.

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Guanidino compounds generate reactive oxygen species

Cited by 34 publications

References 19 publications

Effects of dietary guanidinoacetic acid and betaine supplementation on performance, blood biochemical parameters and antioxidant status of broilers subjected to cold stress

Effects of dietary guanidinoacetic acid and betaine supplementation on performance, blood biochemical parameters and antioxidant status of broilers subjected to cold stress

Growth Performance and Right Ventricular Hypertrophy Responses of Broiler Chickens to Guanidinoacetic Acid Supplementation under Hypobaric Hypoxia

Increase in Resting Levels of Superoxide Anion in the Whole Blood of Uremic Patients on Chronic Hemodialysis

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