Guanidinium-rich lipopeptide functionalized bacteria-absorbing sponge as an effective trap-and-kill system for the elimination of focal bacterial infection

Li, Feng; Lin, Liming; Chi, Jiaying; Wang, Hui; Du, Minqun; Feng, Disang; Wang, Liqing; Luo, Rui; Chen, Hangping; Quan, Guilan; Cai, Jianfeng; Pan, Xin; Wu, Chuanbin; Lü, Chao

doi:10.1016/j.actbio.2022.05.052

Cited by 7 publications

(1 citation statement)

References 51 publications

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“…Certain cationic, amphiphilic polymers with membrane-disrupting properties can enhance the efficacy of antibiotics against pathogenic bacteria. , A combination therapy may be advantageous in aquaculture settings, as polymeric sensitizers have the potential to enhance the efficacy of currently utilized antibiotics, thereby reducing the required antibiotic dosage for effective treatment. A. b is a Gram-negative opportunistic bacterium that has spread globally .…”

Section: Resultsmentioning

confidence: 99%

Broad-Spectrum Antimicrobial Polymer with Dual Bactericidal Mechanisms Enhances Antibiotic Activity in the Treatment of Fish Infections

Yu,

Chen,

et al. 2024

ACS Appl. Polym. Mater.

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Bacterial infection in aquaculture farming has been a well-known issue, and the situation is worsened by the limitations on antibiotic usage due to environmental considerations. This study reports the design and synthesis of a broad-spectrum antimicrobial polymer, P C3−8 , demonstrated for the first time as an efficient antimicrobial agent against a number of common fish pathogens, including Gram-positive and Gram-negative ones. A dual-bactericidal mechanism is proposed for P C3−8 , in which the cationic polymer is found to disrupt bacterial membranes and interact with genome DNA, effectively causing bacterial cell death. P C3−8 is capable of eliminating pathogens in mammalian cell cultures, preventing them from being killed by those pathogens. When P C3−8 was applied into water, it healed bacteria-infected zebrafish, outperforming common antibiotics, such as Kanamycin and Chloramphenicol. Importantly, P C3−8 possesses low drug resistance emergence and potent synergistic effects with commercial antibiotics. Therefore, it shows great effectiveness against resistant pathogens and evades any potential environmental risk related to resistance generation. The present study demonstrates that P C3−8 is a promising antimicrobial agent for treating bacterial infection related fish diseases and has potential applications in the aquaculture industry.

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Section: Resultsmentioning

confidence: 99%

Broad-Spectrum Antimicrobial Polymer with Dual Bactericidal Mechanisms Enhances Antibiotic Activity in the Treatment of Fish Infections

Yu,

Chen,

et al. 2024

ACS Appl. Polym. Mater.

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Imidazole‐Rich, Four‐Armed Host‐Defense Peptidomimetics as Promising Narrow‐Spectrum Antibacterial Agents and Adjuvants against Pseudomonas Aeruginosa Infections

Zheng,

Chi,

et al. 2024

Adv Healthcare Materials

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The development of narrow‐spectrum antimicrobial agents is paramount for swiftly eradicating pathogenic bacteria, mitigating the onset of drug resistance, and preserving the homeostasis of bacterial microbiota in tissues. Owing to the limited affinity between the hydrophobic lipid bilayer interior of bacterial cells and most hydrophilic, polar peptides, the construction of a distinctive class of four‐armed host‐defense peptides/peptidomimetics (HDPs) is proposed with enhanced specificity and membrane perturbation capability against Pseudomonas aeruginosa by incorporating imidazole groups. These groups demonstrate substantial affinity for unsaturated phospholipids, which are predominantly expressed in the cell membrane of P. aeruginosa, thereby enabling HDPs to exhibit narrow‐spectrum activity against this bacterium. Computational simulations and experimental investigations have corroborated that the imidazole‐rich, four‐armed peptidomimetics exhibit notable selectivity toward bacteria over mammalian cells. Among them, 4H10, characterized by its abundant and densely distributed imidazole groups, exhibits impressive activity against various clinically isolated P. aeruginosa strains. Moreover, 4H10 has demonstrated potential as an antibiotic adjuvant, enhancing doxycycline accumulation and exerting effects on intracellular targets by efficiently disrupting bacterial cell membranes. Consequently, the hydrogel composed of 4H10 and doxycycline emerged as a promising topical agent, significantly diminishing the skin P. aeruginosa burden by 97.1% within 2 days while inducing minimal local and systemic toxicity.

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Four-armed host-defense peptidomimetics-augmented vanadium carbide MXene-based microneedle array for efficient photo-excited bacteria-killing

Feng

Xian

et al. 2023

Chemical Engineering Journal

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Guanidinium-rich lipopeptide functionalized bacteria-absorbing sponge as an effective trap-and-kill system for the elimination of focal bacterial infection

Cited by 7 publications

References 51 publications

Broad-Spectrum Antimicrobial Polymer with Dual Bactericidal Mechanisms Enhances Antibiotic Activity in the Treatment of Fish Infections

Broad-Spectrum Antimicrobial Polymer with Dual Bactericidal Mechanisms Enhances Antibiotic Activity in the Treatment of Fish Infections

Imidazole‐Rich, Four‐Armed Host‐Defense Peptidomimetics as Promising Narrow‐Spectrum Antibacterial Agents and Adjuvants against Pseudomonas Aeruginosa Infections

Four-armed host-defense peptidomimetics-augmented vanadium carbide MXene-based microneedle array for efficient photo-excited bacteria-killing

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