Guanidine derivative inhibits C. albicans biofilm growth on denture liner without promote loss of materials’ resistance

García, Isadora Martini; Rodrigues, Stéfani Becker; Gama, Maria Eduarda Rodrigues; Leitune, Vicente Castelo Branco; Melo, Mary Anne S.; Collares, Fabrício Mezzomo

doi:10.1016/j.bioactmat.2020.02.007

Cited by 15 publications

(16 citation statements)

References 37 publications

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“…Prior study exhibited monomers such as poly(2‐tert‐butylaminoethyl) methacrylate (PTBAEMA) incorporated into acrylic resin specimens at high concentrations from 10 to 25% on the viability of C. albicans biofilm cells with no substantial effect (Marra et al, 2012). Another study had shown the inexpressive effect (<1 log reduction) when quaternary monomer with a chain length of 12 carbon was incorporated into heat‐polymerizable liquid blending at concentrations of 10–20% (Chen et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Tooth sealing formulation with bacteria‐killing surface and on‐demand ion release/recharge inhibits early childhood caries key pathogens

et al. 2020

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Herein, we investigated a biointeractive tooth sealing material consisted of dimethylaminohexadecyl methacrylate (DMAHDM) and amorphous calcium phosphate nanoparticles (NACPs) to address the above issues simultaneously. Of note, 5% DMAHDM was incorporated into the resin blend, and 20% NACP was added to inorganic filler content of dental formulations intended as dental sealants. The sealing materials were used to seal human extracted teeth. The sealed teeth were subjected to an early childhood caries (ECC) key pathogen (Candida albicans and Streptococcus mutans) biofilm model using a dynamic caries tooth model (CDC reactor). The biofilm growth over the sealed teeth was assessed via colony-forming unit counting metabolic activity assays. The enamel surface hardness loss, degree of conversion, shear bond strength (SBS), and cytotoxicity were also investigated. Formulations having DMAHDM displayed antibacterial efficiency of 2.8-3.5 and 1.4-4.0 log inhibition for Streptococcus mutans and Candida albicans, respectively. Furthermore, the metabolic activity was reduced on the top of the sealed tooth with the biointeractive sealing materials (p < .05). The degree of conversion values was acceptable. The enamel surface hardness loss decreases (36 ± 9.8%) when in contact with the biointeractive tooth sealing material. The SBS of the combined formulation (5% DMAHDM + 20% NACP) was lower than commercial sealant but similar to experimental control. The investigated sealing material holds valuable dual antibacterial and antifungal activities associated with a reduced mineral loss against the cariogenic challenge promoted by ECC key pathogens.

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Section: Discussionmentioning

confidence: 99%

Tooth sealing formulation with bacteria‐killing surface and on‐demand ion release/recharge inhibits early childhood caries key pathogens

et al. 2020

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“…Candida albicans ( C. albicans ) biofilms have been commonly associated with the development of denture stomatitis. The colonization of C. albicans is mainly attributed to the rough surface texture of dentures and the reduced salivary flow beneath the denture surface, which favors C. albicans biofilm formation and proliferation [ 8 , 9 ]. In a previous study conducted by Ramage et al, scanning electron microscopy analysis of samples of denture acrylic retrieved from patients with denture stomatitis revealed a dense Candida biofilm especially along cracks and rough denture surfaces [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Antibiofilm and Protein-Repellent Polymethylmethacrylate Denture Base Acrylic Resin for Treatment of Denture Stomatitis

et al. 2021

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Candida albicans (C. albicans) biofilm is a common etiological factor in denture stomatitis. The purpose of this study was to investigate the effects of incorporating 2-methacryloyloxyethyl phosphorylcholine (MPC) as a protein repellent into a new high-impact denture acrylic (HIPA) resin on the surface roughness, solution pH, and C. albicans biofilm adhesion to the denture base. The new acrylic denture resin base was formulated by mixing MPC into HIPA resin at mass fractions of 1.5%, 3%, and 4.5%. Surface roughness was measured using a Mitutoyo surface roughness tester. C. albicans biofilm growth and viability were assessed via colony forming unit counts. The pH of the biofilm growth medium was measured using a digital pH meter. Adding MPC to the HIPA resin at percentages of 1.5% and 3% increased the roughness values significantly (P < 0.05), while adding 4.5% MPC resulted in no difference in roughness values to that of the control group (P > 0.05). All experimental groups demonstrated neutral pH values (pH @ 7) and were not significantly different from each other (P > 0.05). Incorporating 2-methacryloyloxyethyl phosphorylcholine at 4.5% resulted in a significant (@1 log) colony-forming unit reduction compared with the control group with 0% MPC (P < 0.05). A fungal-retarding denture acrylic resin was developed through the incorporation of MPC for its protein-repelling properties. This newly developed denture acrylic material has the potential to prevent oral microbial infections, such as denture stomatitis.

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“…24 Chemical agents that do not change this physical property are desirable to maintain the reliability of the material used. 25 The most commonly used material to fabricate the polymeric component of the removable orthodontic appliances is polymethylmethacrylate (PMMA). These polymers are mainly two-part systems that consist of PMMA powder beads and methylmethacrylate monomer liquid with a minute fraction of a crosslinking agent.…”

Section: Discussionmentioning

confidence: 99%

Assessment of surface roughness changes on orthodontic acrylic resin by all-in-one spray disinfectant solutions

Hsu

Balhaddad

García

et al. 2020

J Dent Res Dent Clin Dent Prospects

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Background. The disinfection of orthodontic acrylic resins might change the physical and mechanicalproperties of these materials. We aimed to investigate the impact of four different commercially availabledisinfectants on the surface roughness of acrylic resins used for orthodontic appliances. Methods. Four disinfectant solutions (BirexSE, Opti-Cide3, COEfect MinuteSpray, and CaviCideSpray) were used to disinfect orthodontic acrylic resins using the spraying method. The resins weresubjected to repeated disinfection protocols. Distilled water, also applied via spraying method, was usedas a control. Surface roughness was scrutinized to examine the extent of surface topography changes bystylus profilometry. Data normality was evaluated via the Shapiro–Wilk test, followed by the WilcoxonSigned-Rank test for non-parametric data or paired Student’s t-test for parametric data to compareintra-group differences in roughness before and after the use of the disinfectant solutions. Results. Some of the disinfectants (BirexSE and CaviCide) resulted in significant changes in surfaceroughness values before and after the disinfection compared to the controls (P<0.05). The groups thatwere in contact with distilled water, Opti-Cide, and Coeffect did not exhibit significant differences insurface roughness before and after the intervention (P>0.05). However, from a clinical perspective, theresulting variations in surface roughness (<%0.15) induced by these solutions might not reflect clinicallysignificant differences. Conclusion. The use of disinfectant solutions is unlikely to harm the surface of orthodontic acrylic resins.Oral care providers need to be attentive to the interpretation and implementation of clinically significantchanges in their evidence-based approach regarding potential material damages by disinfection sprays.

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Guanidine derivative inhibits C. albicans biofilm growth on denture liner without promote loss of materials’ resistance

Cited by 15 publications

References 37 publications

Tooth sealing formulation with bacteria‐killing surface and on‐demand ion release/recharge inhibits early childhood caries key pathogens

Tooth sealing formulation with bacteria‐killing surface and on‐demand ion release/recharge inhibits early childhood caries key pathogens

Antibiofilm and Protein-Repellent Polymethylmethacrylate Denture Base Acrylic Resin for Treatment of Denture Stomatitis

Assessment of surface roughness changes on orthodontic acrylic resin by all-in-one spray disinfectant solutions

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