Guanidine- and purine-functionalized ligands of FeIIIZnII complexes: effects on the hydrolysis of DNA

Pereira, Cláudia Maria; Farias, Giliandro; Maranha, Filipy Gobbo; Castilho, Nathalia; Schenk, Gerhard; Souza, Bernardo de; Terenzi, Hernán; Neves, Ademir; Peralta, Rosely A.

doi:10.1007/s00775-019-01680-3

Cited by 15 publications

(19 citation statements)

References 125 publications

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“…In parallel to natural compounds such as bleomycins, transition‐metal complexes have been developed and studied for their DNA binding properties and artificial metallonuclease (AMNs) activity [116–118] . Mixed Fe III Zn II complexes were investigated as purple acid phosphatase mimetics and showed efficient hydrolase activity against DNA [18] . Alternatively, complexes of other redox‐active metals such as Cu, Fe, Mn, Ni, Co, Ru, and Rh can promote oxidative DNA damage at nucleobase and/or deoxyribose moieties.…”

Section: Artificial Metallonucleasesmentioning

confidence: 99%

“…Alternatively, other metals – such as cerium (Ce 4+ ) and zirconium (Zr 4+ ) – can hydrolytically cleave oligonucleotide strands yielding intact 5′‐phosphate and 3′‐hydroxyl termini and offering an alternative to enzymatic nucleases for gene editing and manipulation. Although several interesting classes of nuclease biomimetics have been reported, [18–20] only a few have been targeted to specific sequences under the guidance of a probe.…”

Section: Introductionmentioning

confidence: 99%

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DNA‐Targeted Metallodrugs: An Untapped Source of Artificial Gene Editing Technology

2021

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DNA binding metal complexes are synonymous with anticancer drug discovery. Given the array of structural and chemical reactivity properties available through careful design, metal complexes have been directed to bind nucleic acid structures through covalent or noncovalent binding modes. Several recognition modes – including crosslinking, intercalation, and oxidation – are central to the clinical success of broad‐spectrum anticancer metallodrugs. However, recent progress in nucleic acid click chemistry coupled with advancement in our understanding of metal complex–nucleic acid interactions has opened up new avenues in genetic engineering and targeted therapies. Several of these applications are enabled by the hybridisation of oligonucleotide or polyamine probes to discrete metal complexes, which facilitate site‐specific reactivity at the nucleic acid interface under the guidance of the probe. This Review focuses on recent advancements in hybrid design and, by way of an introduction to this topic, we provide a detailed overview of nucleic acid structures and metal complex–nucleic acid interactions. Our aim is to provide readers with an insight on the rational design of metal complexes with DNA recognition properties and an understanding of how the sequence‐specific targeting of these interactions can be achieved for gene engineering applications.

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Section: Artificial Metallonucleasesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

DNA‐Targeted Metallodrugs: An Untapped Source of Artificial Gene Editing Technology

2021

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“…ii) Variation of the first coordination sphere towards synthesis of homoleptic and hetroleptic complexes [66] , [67] , [68] , [69] , [70] , [71] . iii) Modification of the second coordination sphere via addition of the functional groups or by using the supramolecular hosts such as cyclodextrins (CDs) [56] , [57] , [72] , [73] , [74] , [75] , [76] , [77] , [78] , [79] , [80] , [81] , [82] , [83] . iv) Development of supramolecular systems by the self-assembly of metal complexes and organic building units [84] , [85] , [86] , [87] , [88] .…”

Section: Introductionmentioning

confidence: 99%

Nuclease-like metalloscissors: Biomimetic candidates for cancer and bacterial and viral infections therapy

Anjomshoa

Amirheidari

2022

Coordination Chemistry Reviews

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Despite the extensive and rapid discovery of modern drugs for treatment of cancer, microbial infections, and viral illnesses; these diseases are still among major global health concerns. To take inspiration from natural nucleases and also the therapeutic potential of metallopeptide antibiotics such as the bleomycin family, artificial metallonucleases with the ability of promoting DNA/RNA cleavage and eventually affecting cellular biological processes can be introduced as a new class of therapeutic candidates. Metal complexes can be considered as one of the main categories of artificial metalloscissors, which can prompt nucleic acid strand scission. Accordingly, biologists, inorganic chemists, and medicinal inorganic chemists worldwide have been designing, synthesizing and evaluating the biological properties of metal complexes as artificial metalloscissors. In this review, we try to highlight the recent studies conducted on the nuclease-like metalloscissors and their potential therapeutic applications. Under the light of the concurrent Covid-19 pandemic, the human need for new therapeutics was highlighted much more than ever before. The nuclease-like metalloscissors with the potential of RNA cleavage of invading viral pathogens hence deserve prime attention.

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“…Compared with extensively studied homogeneous catalysts that hydrolyse diverse phosphoester bonds, [28, 32–50] far fewer heterogeneous systems that catalyse the cleavage of such bonds have been developed. Aiming to stimulate progress in this field, we summarise herein advances in the field of heterogeneous catalysts containing metal ions for organophosphate ester degradation by describing the properties of relevant examples.…”

Section: Introductionmentioning

confidence: 99%

“…[18][19][20][21][22][23][24][25][26][27][28][29][30] The use of biomimetic compounds offers a number of advantages, including the possibility to immobilise these compounds on the surface of insoluble solid matrices for easier handling and reuse. [31] Compared with extensivelys tudied homogeneousc atalysts that hydrolyse diverse phosphoester bonds, [28,[32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] far fewer heterogeneous systemst hat catalyse the cleavage of such bonds have been developed. Aimingt os timulate progress in this field, we summarise herein advances in the field of heterogeneous catalysts containing metal ions for organophosphate ester degradation by describing the properties of relevant examples.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Heterogeneous Catalytic Systems Containing Metal Ions for Phosphate Ester Hydrolysis

Gomes

Fernandes

Gahan

et al. 2020

Chemistry A European J

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Organophosphates are a class of organic compounds that are important for living organisms, forming the building blocks for DNA, RNA, and some essential cofactors. Furthermore, non‐natural organophosphates are widely used in industrial applications, including as pesticides; in laundry detergents; and, unfortunately, as chemical weapons agents. In some cases, the natural degradation of organophosphates can take thousands of years; this longevity creates problems associated with handling and the storage of waste generated by such phosphate esters, in particular. Efforts to develop new catalysts for the cleavage of phosphate esters have progressed in recent decades, mainly in the area of homogeneous catalysis. In contrast, the development of heterogeneous catalysts for the hydrolysis of organophosphates has not been as prominent. Herein, examples of heterogeneous systems are described and the importance of the development of heterogeneous catalysts applicable to organophosphate hydrolysis is highlighted, shedding light on recent advances related to different solid matrices that have been employed.

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Guanidine- and purine-functionalized ligands of FeIIIZnII complexes: effects on the hydrolysis of DNA

Cited by 15 publications

References 125 publications

DNA‐Targeted Metallodrugs: An Untapped Source of Artificial Gene Editing Technology

DNA‐Targeted Metallodrugs: An Untapped Source of Artificial Gene Editing Technology

Nuclease-like metalloscissors: Biomimetic candidates for cancer and bacterial and viral infections therapy

Recent Advances in Heterogeneous Catalytic Systems Containing Metal Ions for Phosphate Ester Hydrolysis

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