Gualou Guizhi decoction promotes neurological functional recovery and neurogenesis following focal cerebral ischemia/reperfusion

Han, Jing; Zhang, Jizhou; Zhong, Zhaodong; Li, Zuan-Fang; Pang, Wensheng; Hu, Juan; Chen, Lidian

doi:10.4103/1673-5374.235296

Cited by 16 publications

(4 citation statements)

References 47 publications

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“…Danggui Shaoyao San ( Ren et al, 2015 ), Huatuo zaizao pill ( Duan et al, 2017 ), and Sanhua decoction ( Fu et al, 2020 ) acted at the differentiation stage. Tongxinluo ( Chen L. et al, 2014 ; Chen et al, 2016 ) and Gualou Guizhi decoction ( Han et al, 2018 ) all had an effect on the proliferation and differentiation levels. Huang-Lian-Jie-Du decoction ( Zou et al, 2016 ) and Danggui jakyak San ( Song et al, 2013 ) targeted the stages of proliferation, differentiation, and maturation of neurogenesis.…”

Section: The Effects Of Tcm On Adult Neurogenesis In Neurological And...mentioning

confidence: 99%

What can traditional Chinese medicine do for adult neurogenesis?

Shen

Jiang²,

Zhou

2023

Front. Neurosci.

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Adult neurogenesis plays a crucial role in cognitive function and mood regulation, while aberrant adult neurogenesis contributes to various neurological and psychiatric diseases. With a better understanding of the significance of adult neurogenesis, the demand for improving adult neurogenesis is increasing. More and more research has shown that traditional Chinese medicine (TCM), including TCM prescriptions (TCMPs), Chinese herbal medicine, and bioactive components, has unique advantages in treating neurological and psychiatric diseases by regulating adult neurogenesis at various stages, including proliferation, differentiation, and maturation. In this review, we summarize the progress of TCM in improving adult neurogenesis and the key possible mechanisms by which TCM may benefit it. Finally, we suggest the possible strategies of TCM to improve adult neurogenesis in the treatment of neuropsychiatric disorders.

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Section: The Effects Of Tcm On Adult Neurogenesis In Neurological And...mentioning

confidence: 99%

What can traditional Chinese medicine do for adult neurogenesis?

Shen

Jiang²,

Zhou

2023

Front. Neurosci.

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“…It is commonly associated with neuronal rewiring following brain or spinal cord injury, and therefore its increased level following treatment with HM, such as Buyang Huanwu decoction (BHD), is an indicator of therapeuticallymediated axonal regrowth and remodelling (Fig. 7) [76,77,78].…”

Section: Antioxidation -Hemeoxygenase 1 (Ho1)mentioning

confidence: 99%

Pathophysiology of ischemic reperfusion injury and the molecular targets involved in amelioration of brain injury by herbal medicine

Badamasi¹

2021

J Pre Clin Clin Res.

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“…The mechanisms of its neuroprotective effect and ability to induce post‐conditioning are mainly related to the formation of reactive oxygen species, activation of cellular signalling pathways, and have an influence on mitochondria. Based on our previous studies, we showed that ISO post‐treatment plays a beneficial role in resisting brain I/R injury through the TGF‐β/Smad‐MAPK signalling pathway 15,16 …”

Section: Introductionmentioning

confidence: 99%

“…Based on our previous studies, we showed that ISO post-treatment plays a beneficial role in resisting brain I/R injury through the TGFβ/Smad-MAPK signalling pathway. 15,16 Despite the demonstrated protective effects of ISO, studies on ISO post-conditioning activation signalling pathways are limited and deserve further study. One possible mechanism may be through the activation of extracellular signal-regulated kinase 5 (ERK5).…”

mentioning

confidence: 99%

Isoflurane post‐conditioning contributes to anti‐apoptotic effect after cerebral ischaemia in rats through the ERK5/MEF2D signaling pathway

Zhang

Yin

et al. 2021

J Cellular Molecular Medi

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The mechanisms of brain protection during ischaemic reperfusion injury induced by isoflurane (ISO) post‐conditioning are unclear. Myocyte enhancement factor 2 (MEF2D) has been shown to promote neural survival in a variety of models, in which multiple survival and death signals converge on MEF2D and modulate its activity. Here, we investigated the effect of MEF2D on the neuroprotective effects of ISO post‐conditioning on rats after cerebral ischaemia/reperfusion (I/R) injury. Rats underwent middle cerebral artery occlusion (MCAO) surgery with ischaemia for 90 minutes and reperfusion for 24‐48 hours. After MCAO, neurological status was assessed at 12, 24 and 48 hours by the Modified Neurological Severity Score (mNSS) test. The passive avoidance test (PAT) was used to assess cognition function. Histological and neuropathological evaluations were performed with HE staining and Nissl's staining, respectively. We measured the expression of MEF2D, ERK5, GFAP and caspase‐3 by immunofluorescent staining and Western blotting, and TUNEL staining to assess the severity of apoptosis in hippocampal CA1 area. We found that MEF2D was involved in nerve protection after I/R injury, and post‐treatment of ISO significantly promoted the phosphorylation of ERK5, increased MEF2D transcriptional activity, inhibited the expression of caspase‐3 and played a role of brain protection.

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Gualou Guizhi decoction promotes neurological functional recovery and neurogenesis following focal cerebral ischemia/reperfusion

Cited by 16 publications

References 47 publications

What can traditional Chinese medicine do for adult neurogenesis?

What can traditional Chinese medicine do for adult neurogenesis?

Pathophysiology of ischemic reperfusion injury and the molecular targets involved in amelioration of brain injury by herbal medicine

Isoflurane post‐conditioning contributes to anti‐apoptotic effect after cerebral ischaemia in rats through the ERK5/MEF2D signaling pathway

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