Guaianolides from two subspecies of Amphoricarpos neumayeri from Montenegro

Leaf micromorphology, antioxidative activity and a new record of 3-deoxyamphoricarpolide of relict and limestone endemic Amphoricarpos elegans Albov (compositae) from Georgia

“…2). After comparison with chromatograms and retention characteristics of previously isolated and characterized amphoricarpolides from Balkan species of Amphoricarpos, it was concluded that this dominant peak is 3-deoxyamphoricarpolide [26].…”

“…The Balkan species of Amphoricarpos has been the subject of some phytochemical [26][27][28], biological activity [14,29,11], morphological [31] and taxonomic studies [32]. To the best of our knowledge, there is only one study describing the morphology and anatomy of A. elegans [31], but there are no data dealing with micromorphological, phytochemical and examinations of the biological activities of this species.…”

Ethnobotany and Biocultural Diversities in the Balkans

“…murbeckii (Bošnjak) ( Asteraceae), the highland endemic of the western part of the Balkan Peninusula, inhabiting cracks of carbonate rocks from central Bosnia to northwest Greece, were collected on several localities, such as Canyon of river Tara and mountains Sinjajevina, Komovi, Visitor, Zeletin, and Karanfili (Prokletije). Extensive spectroscopic ( 1 H NMR) and HPLC PDA/ESI MS analysis of the crude extracts and their purified constituents revealed 21 new guaianolide SLs, named amphoricarpolides (Djordjević et al 2004;Djordjević et al 2006) as the main constituents (≥ 1 % per weight of dried plant material). Some of the isolated amphoricarpolides were screened for their cytotoxicity on human cervical cancer (HeLa) and murine melanoma (B16) cell lines, and most of them have shown reasonable cytotoxic activities (Atrrog et al 2009).…”

Lipophilicity of some guaianolides isolated from two endemic subspecies of Amphoricarpos neumayeri (Asteraceae) from Montenegro

“…1) were isolated according to a previously described procedure (Djordjevic et al, 2004(Djordjevic et al, , 2006.…”

“…neumayeri collected at the Orjen Mountain and ssp. murbeckii Bošnjak originating from the Visitor and Karanfili mountains (Djordjevic et al, 2004(Djordjevic et al, , 2006 afforded 21 amphoricarpolides-guaianolide type sesquiterpene γ-lactones with the same relative (1α H, 4β H, 5α H, 7β H) configuration of the basic skeleton. Based on our interest in the relationship between structure and biological activity of guaianolides, our work was mainly focused on the quantification of their lipophilicity as a source of valuable information for QSRR and QSAR investigations.…”