GTP-binding protein Di-RAS3 diminishes the migration and invasion of non-small cell lung cancer by inhibiting the RAS/extracellular-regulated kinase pathway

DIRAS3 enhances RNF19B-mediated RAC1 ubiquitination and degradation in non-small-cell lung cancer cells

“… 31 , 32 , 33 DIRAS3 overexpression was reported to suppress the malignant progression of tumor cells via modulating apoptosis, autophagy, proliferation, or migration. 16 , 26 , 34 As a tumor suppressor protein of the RAS family, DIRAS3 directly bound to RAS through its unique N-terminal extension, inhibiting RAS clustering and suppressing the RAF kinase and downstream MAPK signaling pathway. 27 In addition, re-expression of DIRAS3 blocked FAK-mediated RHOA signaling, resulting in decreased levels of GTP-RHOA in epidermal growth factor-stimulated ovarian cancer cells.…”

“… 17 , 19 , 20 , 21 Consequently, the downregulation of DIRAS3 has been confirmed in breast, lung, thyroid, prostate, pancreatic, and hepatocellular carcinoma. 22 , 23 , 24 , 25 , 26 It is worth noting that, like other members of the RAS family, DIRAS3 can attach to the inner leaflet of the plasma membrane to regulate the expression or activity of some small G proteins, such as RHOA and RAS. 19 , 27 …”