“…Suppression of acr‐2(gf) by gtl‐2(lf) also depends on another TRPM channel gtl‐1 . Both GTL‐2 and GTL‐1 are permeant to divalent cations, respond to intracellular calcium and in turn regulate cellular ion homeostasis (Cohen, Kumar, Zinger, Priel, & Treinin, 2019; Teramoto et al., 2010; Xing, Yan, Estevez, & Strange, 2008). Supporting an idea that systematic extracellular ionic composition could influence excitation‐inhibition imbalance of the locomotor circuit, treatment of acr‐2(gf) with divalent cation chelators recapitulated the observed effects of gtl‐2(lf) (Stawicki et al., 2011).…”