GSTT1, GSTM1, and CYP1B1 gene polymorphisms and susceptibility to sporadic renal cell cancer

Salinas-Sánchez, Antonio S.; Sánchez-Sánchez, Francisco; Donate-Moreno, María J.; Rubio‐del‐Campo, Antonio; Serrano-Oviedo, Leticia; Bachs, J.M. Giménez; Martínez-Sanchiz, C.; Segura-Martín, Miguel; Escribano, Julio

doi:10.1016/j.urolonc.2010.10.001

Cited by 25 publications

(17 citation statements)

References 26 publications

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“…Quantitative PCR validation confirmed the heterozygous deletion of this region in PTCH1 (Figure S4 in Additional file 1). Similarly, Figure 4 shows the homozygous deletion of a small region centered on GSTT1 ; homozygous deletion of this gene has been associated with increased susceptibility to many different cancer types, including prostate cancer, renal cancers and osteosarcoma [32-35]. The Infinium data indicate this deletion spans approximately 12 kb and contains GSTT1 and a small proportion of the neighboring LOC391322 only (Figure 8).…”

Section: Resultsmentioning

confidence: 99%

Using high-density DNA methylation arrays to profile copy number alterations

et al. 2014

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The integration of genomic and epigenomic data is an increasingly popular approach for studying the complex mechanisms driving cancer development. We have developed a method for evaluating both methylation and copy number from high-density DNA methylation arrays. Comparing copy number data from Infinium HumanMethylation450 BeadChips and SNP arrays, we demonstrate that Infinium arrays detect copy number alterations with the sensitivity of SNP platforms. These results show that high-density methylation arrays provide a robust and economic platform for detecting copy number and methylation changes in a single experiment. Our method is available in the ChAMP Bioconductor package: http://www.bioconductor.org/packages/2.13/bioc/html/ChAMP.html.

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Section: Resultsmentioning

confidence: 99%

Using high-density DNA methylation arrays to profile copy number alterations

et al. 2014

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“…A study conducted recently in Spain also reported GSTT1 deletion but not GSTM1 deletion to be associated with advanced stages of RCC (Salinas-Sánchez et al, 2011). There was also trend of higher cancer stage and grade with higher BMI.…”

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confidence: 83%

Impact of Glutathione TransferaseM1, T1,andP1Gene Polymorphisms in the Genetic Susceptibility of North Indian Population to Renal Cell Carcinoma

Ahmad

Arjumand

Seth

et al. 2012

DNA and Cell Biology

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In this study, we investigated the association of GSTP1, GSTM1, and GSTP1 genetic variants with renal cell carcinoma (RCC) among North Indian patients. The difference in frequency of the GSTT1 null genotype between cases and control subjects was statistically significant (active ver. null, odds ratio [OR]=0.368; confidence intervals [CI] 95%=0.243-0.557, p=0.001). The differences in the frequency of GSTP1 genotypes were statistically significant (AA ver. AG/GG, OR=1.879; CI 95%=0.355-0.797, p=0.002). Higher allelic frequency of the GSTP1 G allele was associated with RCC cases (G ver. A allele, OR=1.534; 95% CI=1.159-2.030, p=0.003). The gene-gene interaction in terms of three-way combination of GSTM1 null, GSTT1 null, and GSTP1 (AG/GG) resulted in 4.5-fold increase in RCC risk (OR=4.452; 95% CI=2.220-9.294). Similarly, our study revealed that GST polymorphism might be a vital determinant of advancement to higher pathological stages and histological grades of RCC. Our findings suggest that genetic variability in members of the GST gene family may be associated with an increased susceptibility to RCC and its progression.

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“…It has been reported that different allelic variants of CYP1B1 have different catalytic activities and specificities to procarcinogens, thus partly explains molecular mechanism of CYP1B1 in carcinogenesis [34]. Except for prostate cancer, case–control studies have shown inconsistent associations between CYP1B1 L432V polymorphism and bladder cancer and renal cancer risk [24,28,29]. However, exact mechanisms of how CYP1B1 polymorphism contributes to urinary cancer susceptibility requires further illustration.…”

Section: Resultsmentioning

confidence: 99%

Association of CYP1B1 L432V polymorphism with urinary cancer susceptibility: a meta-analysis

et al. 2014

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BackgroundThe Cytochrome P450 1B1 (CYP1B1) is a key P450 enzyme involved in the metabolism of exogenous and endogenous substrates. Previous studies have reported the existence of CYP1B1 L432V missense polymorphism in prostate, bladder and renal cancers. However, the effects of this polymorphism on the risk of these cancers remain conflicting. Therefore, we performed a meta-analysis to assess the association between L432V polymorphism and the susceptibility of urinary cancers.MethodsWe searched the PubMed database without limits on language for studies exploring the relationship of CYP1B1 L432V polymorphism and urinary cancers. Article search was supplemented by screening the references of retrieved studies manually. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated to evaluate the strength of these associations. Simultaneously, publication bias was estimated by funnel plot and Begg’s test with Stata 11 software.ResultsWe observed a significant association between CYP1B1 L432V polymorphism and urinary cancers. The overall OR (95% CI) of CC versus CG was 0.937 (0.881-0.996), the overall OR (95% CI) of CC versus CG + GG was 0.942 (0.890-0.997). Furthermore, we identified reduced risk for CC versus other phenotypes in both prostate and overall urinary cancers, when studies were limited to Caucasian or Asian patients.ConclusionsThis meta-analysis suggests that the CYP1B1 L432V polymorphism is associated with urinary cancer risk.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3108829721231527

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GSTT1, GSTM1, and CYP1B1 gene polymorphisms and susceptibility to sporadic renal cell cancer

Cited by 25 publications

References 26 publications

Using high-density DNA methylation arrays to profile copy number alterations

Using high-density DNA methylation arrays to profile copy number alterations

Impact of Glutathione TransferaseM1, T1,andP1Gene Polymorphisms in the Genetic Susceptibility of North Indian Population to Renal Cell Carcinoma

Association of CYP1B1 L432V polymorphism with urinary cancer susceptibility: a meta-analysis

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