GSTT1 and GSTM1 gene polymorphisms in European and African populations

Piacentini, Sara; Polimanti, Renato; Porreca, Flavia; Martínez-Labarga, Cristina; Stefano, G. F. De; Fuciarelli, Maria

doi:10.1007/s11033-010-0221-0

Cited by 74 publications

(59 citation statements)

References 32 publications

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“…The frequencies of GSTT1 deletion in our populations were higher than that described for Europeans, including British (18%) [20], French (16%) [21], German (13%) [22] and Austrian (20%) [23], as well as for other Middle Eastern populations, including Turks (17.3%) [24], and Iranians (21.2%) [25], but was significantly lower than SouthEast Asians, such as Chinese (56.5%) [26], Koreans (53.8%) [27] and Japanese (44%) [28]. The frequencies of GSTT1 null genotype in our Arab populations are similar to that of the sub-Saharan Africans: Zimbabweans (26%) [30], Gambians (37.1%) [31], Cameroonians (46.8%) [32] and Ivory Coast (33.1%) [33] (Table 2). The difference of GTSM1 and GSTT1 null alleles' frequency between our samples and those of others is attributed to their evolutionary histories, and also to selection arising from varied exposures to toxic substances.…”

Section: Discussionsupporting

confidence: 52%

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Genetic Polymorphism of the Glutathione S-Transferase M1 and T1 Genes in Three Distinct Arab Populations

et al. 2011

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Abstract. Deletion polymorphisms for the glutathione S-transferase (GST) gene are associated with increased risk of cancer, and are implicated in detoxifying mutagenic electrophilic compounds. GST Polymorphic variants were reported for different populations. The aim of this study was to investigate the frequencies of GSTM1 and GSTT1 null genotypes among Bahraini, Lebanese and Tunisian Arabs. GST genotyping was done by multiplex PCR-based methods. Study subjects comprised 167 Bahrainis, 141 Lebanese and 186 Tunisians unrelated healthy individuals. GSTM1 deletion homozygosity of 49.7%, 52.5% and 63.4% were recorded for Bahraini, Lebanese and Tunisians, respectively. Among Bahrainis, the prevalence of GSTT1 null homozygotes was 28.7%, while in higher rates were seen in Lebanese (37.6%) and Tunisians (37.1%). Our results indicate that there are no major differences in allelic distribution of GSTM1 and GSTT1 genes between the three Arab populations investigated except between Bahrainis and Tunisians regarding the allelic distribution of GSTM1 gene (P = 0.013). Combined analysis of both genes revealed that 14.4% of Bahrainis, 16.3% of Lebanese and 21.0% of Tunisians harbor the deleted genotype of both genes. This is the first study that addresses GST gene polymorphism in Bahraini and Lebanese Arabs, and will help genetic studies on the association of GSTM1 and GSTT1 polymorphisms with disease risks and drug effects in Arab populations.

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Section: Discussionsupporting

confidence: 52%

“…Significant differences in GSTM1 null genotype distribution were seen with respect to Indians (20.7%) [29], and Africans, including Zimbabweans (24%) [30], Gambians (20.2%) [31], Cameroonians (27.8%) [32], and Ivory Coast (36.1%) [33] (Table 2).…”

Section: Discussionmentioning

confidence: 99%

Genetic Polymorphism of the Glutathione S-Transferase M1 and T1 Genes in Three Distinct Arab Populations

et al. 2011

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“…In another study involving a population from central Italy, the frequencies were found to be 50.4% and 16.7%, respectively (Table 3) [58] . The frequencies of the GSTM1 and GSTT1 null phenotypes in Italian population [57,58] are in line with those observed in Caucasian populations, 40% -65% and 10% -40%, respectively [57,90] .…”

supporting

confidence: 87%

“…In a study from a large sample of an Italian population, the frequencies of GSTM1 and GSTT1 null genotype were found to be 49.2% and 28.3%, respectively [57] . In another study involving a population from central Italy, the frequencies were found to be 50.4% and 16.7%, respectively (Table 3) [58] .…”

mentioning

confidence: 96%

Pharmacogenetics of drug-metabolizing enzymes in Italian populations

Serpe

Canaparo

Scordo

et al. 2014

Drug Metabolism and Personalized Therapy

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: Drug-metabolizing enzymes play a major role in the biotransformation and subsequent elimination of most drugs and xenobiotics from the body. Both phase I and phase II enzymes are highly polymorphic. Inter-individual differences in genes coding for drug-metabolizing enzymes are important for understanding variability in drug response and for individualization of drug prescription. The prevalence of genetic polymorphisms in drug metabolism varies widely with ethnicity, and marked differences in the distribution of allelic variants of genes encoding drug-metabolizing enzymes have been documented in populations of different racial origin. This review aimed to summarize the available studies on genetic polymorphisms associated with drug metabolism conducted in Italian populations and to compare the frequency of the various metabolizer phenotypes and most common variant alleles (and resulting genotypes) with corresponding values from other populations. Notably, published data are not extensive, and most studies were performed on relatively low numbers of individuals. In general, the frequency of polymorphisms in the cytochrome P450 ( CYP ) genes as well as in the investigated phase II enzymes in the Italian population was similar to values reported for other Caucasian populations. However, the prevalence of CYP2D6 gene duplication among Italians was found to be very high, confirming the higher frequency of CYP2D6 ultrarapid metabolizers in the Mediterranean area compared to Northern Europe. It is worth noting that a geographic gradient in the flavin-containing monooxygenase 3 polymorphism distribution was also seen, the Italian population showing higher similarity to other Mediterranean populations than to North Europeans.

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“…The frequency of the GSTM1 null genotype in the present study was significantly higher than those in Asian populations, that is, Indian and Japanese (Kihara and Noda, 1999;Sharma et al, 2012) populations, and African populations, that is, Zimbabwean and Cameroonian populations (Piacentini et al, 2011). Likewise, the frequency of the GSTT1 nullgenotype in the Saudi population is 20.1%.…”

Section: Discussioncontrasting

confidence: 45%

Frequency of glutathione-S-transferase null-M1 and null-T1 genotypes among the Turabah population in Saudi Arabia

Mansour

Askar

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Glutathione-S-transferases (GST) are key phase II detoxifying enzymes that play critical roles in protection against products of oxidative stress and against electrophiles. Glutathione S-transferase mu (GST-M1) and theta (GST-T1) are isoforms of glutathione transferase enzymes that participate in the metabolism of a wide range of chemicals. Deletion variants that are associated with a lack of enzyme function exist at both these loci. The frequencies of homozygous GSTM1 and GSTT1 deletion carriers are very high in most of the populations studied to date. The aim of this study was to investigate the frequencies of GSTM1 and GSTT1 genotypes among the Turabah population in Saudi Arabia in comparison with the data published for some other Arabic populations. The subjects consisted of 164 unrelated healthy individuals from the Turabah population. GST genotyping was performed by multiplex polymerase chain reaction-based (2015) methods. The GSTM1 deletion homozygosity was 56.1% and GSTT1 deletion homozygosity was 20.7%, while the GSTM1 and GSTT1 doubledeletion homozygosity was 11.0%. Comparison with published data from Bahraini, Lebanese, and Tunisian populations demonstrated no significant difference for GSTM1 between these populations. The GSTT1 null-allele frequency was significantly lower than those for the Lebanese and Tunisian populations (P = 0.001) but similar to that for the Bahraini population (P = 0.099). Characterization of GST genetic polymorphisms in the Saudi population may aid in genetic studies on the association of GSTM1 and GSTT1 polymorphisms with disease risks and the pharmacogenetics of chemotherapy.

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GSTT1 and GSTM1 gene polymorphisms in European and African populations

Cited by 74 publications

References 32 publications

Genetic Polymorphism of the Glutathione S-Transferase M1 and T1 Genes in Three Distinct Arab Populations

Genetic Polymorphism of the Glutathione S-Transferase M1 and T1 Genes in Three Distinct Arab Populations

Pharmacogenetics of drug-metabolizing enzymes in Italian populations

Frequency of glutathione-S-transferase null-M1 and null-T1 genotypes among the Turabah population in Saudi Arabia

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