GSTM1, GSTT1, and GSTP1 polymorphism and lung cancer risk in relation to tobacco smoking

Schneider, Joachim; Bernges, Ulrike; Philipp, Monika; Woitowitz, H.‐J.

doi:10.1016/j.canlet.2004.01.002

Cited by 119 publications

(84 citation statements)

References 22 publications

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“…Four studies had relatively large sample sizes; one study reported that the GSTM1 and GSTT1 null genotypes were associated with increased risk of LC (Spitz et al, 2000), two reported that the GSTM1 null genotype was associated with increased risk of LC and the GSTT1 null genotype with decreased risk (Alexandrie et al, 2004;Schneider et al, 2004), and one reported that the GSTM1 null genotype was associated with decreased risk of LC and the GSTT1 null genotype with increased risk (Larsen et al, 2006). A recent meta-analysis found that the GSTM1 and GSTT1 null genotypes were associated with LC risk among East Asians (Langevin et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…The GSTM1 and GSTT1 null genotypes have been linked to increased risk of developing lung, bladder, colon, and skin cancers (Bell et al, 1993;Hayes and Pulford, 1995;Nakajima et al, 1995), and several studies have shown that GSTM1 or GSTT1 null genotypes were associated with increased risk of LC (Cote et al, 2005;Cote et al, 2009;Schneider et al, 2004;Spitz et al, 2000). However, some data have suggested that no relationship exists between the GSTM1 or GSTT1 null genotype and the risk of LC (Alexandrie et al, 2004;Larsen et al, 2006).…”

Section: Glutathione-s-transferase (Gstm1 Gstt1) Null Phenotypes Andmentioning

confidence: 99%

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Glutathione-S-transferase (GSTM1, GSTT1) Null Phenotypes and Risk of Lung Cancer in a Korean Population

Piao

Shin²,

Kim³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Section: Glutathione-s-transferase (Gstm1 Gstt1) Null Phenotypes Andmentioning

confidence: 99%

Glutathione-S-transferase (GSTM1, GSTT1) Null Phenotypes and Risk of Lung Cancer in a Korean Population

Piao

Shin²,

Kim³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…This genetic variation may change the susceptibility of an individual to carcinogens and toxins, an identical affect on the toxicity and efficacy of certain drugs (14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Association of the p53 or GSTM1 polymorphism with the risk of nasopharyngeal carcinoma: A meta-analysis

Wu¹,

Huang

Liu

et al. 2015

Molecular and Clinical Oncology

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Abstract. p53 and glutathione S-transferase M1 (GSTM1) are the most popular suppressor genes. Several previous studies demonstrated positive associations of these gene polymorphisms with numerous cancer types, including hepatocellular cancer, while the association between p53/GSTM1 polymorphisms and the nasopharyngeal carcinoma (NPC) risk was inconsistent and underpowered. However, no studies investigating the combinational effect of these two genes on NPC risk were performed. To confirm the effects of p53 and GSTM1 polymorphisms on the risk of NPC, a meta-analysis of all the available previous studies associating p53 and GSTM1 with the risk of NPC was performed. A comprehensive search of PubMed, Web of Science and SD database until November 2014 was performed to identify the relevant studies. The data were extracted by two independent authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Meta-regression and subgroup analyses were performed to identify the source of heterogeneity. Finally, five studies with 1,419 cases and 1,707 controls were included for the p53 polymorphism and three studies with 837 cases and 1,299 controls were included for the GSTM1 polymorphism. Regarding p53, a significantly increased NPC risk was observed in the overall population (C vs. G, OR, 1.245; 95% CI, 1.045-1.483; P=0.014; additive models: CC vs. GG, OR, 1.579; 95% CI, 1.100-2.265; P=0.013 and CG vs. GG, OR, 1.230; 95% CI, 1.039-1.456; P=0.016; dominant model, OR, 1.321; 95% CI, 1.127-1.549; P=0.001; recessive model, OR, 1.429; 95% CI, 1.017-2.009; P=0.040). Concerning GSTM1, a significantly increased NPC risk was observed in the overall population (null versus non-null, OR, 1.282; 95% CI, 1.075-1.530; P=0.006). In the subgroup analyses stratified by the source of controls, a significant association of p53 with NPC risk was also demonstrated, while no association with GSTM1 was observed. Therefore, the p53 G72C polymorphism may have a susceptible role in the carcinogenesis of NPC, while genetic deletion of GSTM1 may contribute to increased susceptibility to NPC. Further large and well-designed studies are required to confirm this association.

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“…Epidemiological studies have demonstrated tobacco smoking as well as environmental tobacco smoke in non-tobacco users as the major risk factor in the development of lung cancer (Zhong et al, 2000;Parkin et al, 2001). However, only 10-15% of lifelong smokers develop lung cancer indicating that genetic factors may play an important role in determining the susceptibility to lung cancer (Hecht et al, 1999;Strange et al, 1999;Schneider et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Four Polymorphisms in the Cytochrome P450 1A2 (CYP1A2) Gene and Lung Cancer Risk: a Meta-analysis

Ye²,

Cheng³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Previous published data on the association between CYP1A2 rs762551, rs2069514, rs2069526, and rs2470890 polymorphisms and lung cancer risk have not allowed a definite conclusion. The present metaanalysis of the literature was performed to derive a more precise estimation of the relationship. Materials and Methods: 8 publications covering 23 studies were selected for this meta-analysis, including 1,665 cases and 2,383 controls for CYP1A2 rs762551 (from 8 studies), 1,456 cases and 1,792 controls for CYP1A2 rs2069514 (from 7 studies), 657 cases and 984 controls for CYP1A2 rs2069526 (from 5 studies) and 691 cases and 968 controls for CYP1A2 rs2470890 (from 3 studies). Results: When all the eligible studies were pooled into the meta-analysis for the CYP1A2 rs762551 polymorphism, significantly increased lung cancer risk was observed in the dominant model (OR=1.21, 95 % CI=1.00-1.46). In the subgroup analysis by ethnicity, significantly increased risk of lung cancer was observed in Caucasians (dominant model: OR=1.29, 95%CI=1.11-1.51; recessive model: OR=1.33, 95%CI=1.01-1.75; additive model: OR=1.49, 95%CI=1.12-1.98). There was no evidence of significant association between lung cancer risk and CYP1A2 rs2069514, s2470890, and rs2069526 polymorphisms. Conclusions: In summary, this meta-analysis indicates that the CYP1A2 rs762551 polymorphism is linked to an increased lung cancer risk in Caucasians. Moreover, our work also points out the importance of new studies for rs2069514 associations in lung cancer, where at least some of the covariates responsible for heterogeneity could be controlled, to obtain a more conclusive understanding about the function of the rs2069514 polymorphism in lung cancer development.

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GSTM1, GSTT1, and GSTP1 polymorphism and lung cancer risk in relation to tobacco smoking

Cited by 119 publications

References 22 publications

Glutathione-S-transferase (GSTM1, GSTT1) Null Phenotypes and Risk of Lung Cancer in a Korean Population

Glutathione-S-transferase (GSTM1, GSTT1) Null Phenotypes and Risk of Lung Cancer in a Korean Population

Association of the p53 or GSTM1 polymorphism with the risk of nasopharyngeal carcinoma: A meta-analysis

Four Polymorphisms in the Cytochrome P450 1A2 (CYP1A2) Gene and Lung Cancer Risk: a Meta-analysis

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