GSTM1 enzyme concentration and enzyme activity in correlation to the genotype of detoxification enzymes in squamous cell carcinoma of the oral cavity

Gronau, Silke; Koenig-Greger, D.; Jerg, M; Riechelmann, Herbert

doi:10.1034/j.1601-0825.2003.02866.x

Cited by 44 publications

(25 citation statements)

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“…5,44,81,82,99,100 Hospital patients were used as controls in 16 studies. 5,44,71,72,78,[81][82][83][84][85]88,92,93,[97][98][99] The number of cases in the studies included in the meta-analysis for GSTM1 deletion varied from 21 to 451 patients. All studies undertaken in Europe included Ͻ150 cases, with two of these having Ͻ50 cases.…”

Section: Resultsmentioning

confidence: 99%

“…95 In South America these values ranged from 38.2% to 48.7% 71,79,97,98 and in Europe and United States from 51% to 54.8%. 5,44,[81][82][83]99,100 For the CYP1A1 exon 7 polymorphism, large geographical heterogeneity could be observed. The frequency of the homozygote genotype for the variant allele in the controls was absent or very low in Europe (0 -6%) whereas the heterozygous genotype was very rare (6 -9.3%).…”

Section: Population Frequenciesmentioning

confidence: 99%

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Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review

Varela-Lema

Taioli

Ruano-Raviña

et al. 2008

Genetics in Medicine

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The association of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers was assessed through a metaanalysis of published case-control studies and a pooled analysis of both published and unpublished case-control studies from the Genetic Susceptibility to Environmental Carcinogens database (http://www.upci.upmc.edu/research/ccps/ccontrol/ index.html). Thirty publications used in the meta-analysis included a total of 7783 subjects (3177 cases and 4606 controls); 21 datasets, 9397 subjects (3130 cases and 6267 controls) were included in the pooled analysis. The GSTM1 deletion was 2-fold more likely to occur in African American and African cases than controls (odds ratio: 1.7, 95% confidence interval: 0.9-3.3), although this was not observed among whites (odds ratio: 1.0, 95% confidence interval: 0.9-1.1). The metaanalysis and pooled analysis showed a significant association between oral and pharyngeal cancer and the CYP1A1 MspI homozygous variant (meta-OR m2/m2 : 1.9, 95% confidence interval: 1.4-2.7; Pooled OR m2m2 : 2.0, 95% confidence interval:1.3-3.1; OR m1m2 or [infi]m2m2 : 1.3, 95% confidence interval: 1.1-1.6). The association was present for the CYP1A1 (exon 7) polymorphism (OR Val/Val : 2.2, 95% confidence interval: 1.1-4.5) in ever smokers. A joint effect was observed for GSTM1 homozygous deletion and the CYP1A1 m1m2 variant on cancer risk. Our findings suggest that tobacco use and genetic factors play a significant role in oral and pharyngeal cancer. Genet Med 2008:10(6):369-384. Key Words: GSTM1, CYP1A1, oral and pharyngeal cancers, epidemiology, meta-analysis and pooled analysis Glutathione S-transferasesThe Glutathione S-transferases (GSTs) comprise a family of phase II detoxifying enzymes that catalyze a large number of reactions taking place between the cytosolic glutathione and compounds containing an electrophilic center. 1 These enzymes are involved in the elimination of xenobiotics and endogenous products of oxidative stress formed as a result of aerobic metabolism, exposure to ionizing radiation or any other process that causes cellular damage. Substrates for GSTs include acetaldehyde and several polyaromatic hydrocarbons (PAHs) found in tobacco smoke. The main steps for GST catalysis includes the formation of a complex with the cytosolic glutathione and the ionization of the sulfydryl group of this enzyme bound to glutathione to yield a highly reactive thiolate anion through hydrogen bonding with the adjacent hydroxyl

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Section: Resultsmentioning

confidence: 99%

Section: Population Frequenciesmentioning

confidence: 99%

Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review

Varela-Lema

Taioli

Ruano-Raviña

et al. 2008

Genetics in Medicine

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“…Metabolism of this carcinogen involves a balance between the activation steps mediated by the epoxide hydrolase and the cytochrome system and the detoxification steps, involving GSTM1, that inhibit the activity of the DNA binding intermediates and catalyze the conversion of the reactive electrophiles to inactive, water-soluble conjugates that can be easily removed [13]. Even though frequencies of GSTM1 null genotypes vary among different ethnic groups, in white Caucasians, it is deleted in approximately 50% of the population [24–33]. …”

Section: Introductionmentioning

confidence: 99%

CYP1A1, mEH, and GSTM1 Polymophisms and Risk of Oral and Pharyngeal Cancer: A Spanish Case-Control Study

Varela-Lema

Ruano-Raviña

Crespo³

et al. 2008

Journal of Oncology

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Background. Genetic polymorphisms of drug metabolizing enzymes involved in the detoxification pathways of carcinogenic substances may influence cancer risk. Methods. Case-control study that investigates the relationship between CYP1A1 Ile/Val, exon 4 mEH, and GSTM1 null genetic polymorphism and the risk of oral and pharyngeal cancer examining the interaction between these genes, tobacco, and alcohol. 92 incident cases and 130 consecutive hospital-based controls have been included. Results. No significant associations were found for any of the genotypes assessed. The estimated risk was slightly elevated in subjects with the wild type of the mEH gene and the null GSTM1 genotype. For exon 4 mEH heterozygous polymorphism, the risk was slightly lower for heavy smokers than for light smokers. The inverse association was observed for the GSTM1 null genotype. Conclusions. The results suggest that exon 4 mEH and GSTM1 null polymorphisms might influence oral and pharyngeal cancer.

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“…The homozygous deletion (0/0), or null genotype, which leads to copy number variations (CNVs) at either the GSTM1 or the GSTT1 locus, resulted in loss of enzyme function. Originally, it was hypothesized that this locus was associated with the susceptibility to autoimmune conditions, such as lupus erythematosus and various forms of cancer, including oral, gastric, colorectal, prostate, bladder, and hepatic cancer and renal cell carcinoma (Economopoulos and Sergentanis 2010 ;Gronau et al 2003 ;Hayes and Pulford 1995 ;Simic et al 2009 ;Zhang et al 2010Zhang et al , 2011.…”

Section: Glutathione S-transferase Genementioning

confidence: 99%

Genetic Polymorphism Related to Oxidative Stress in Autism

Yoo

2014

Oxidative Stress in Applied Basic Research and Clinical Practice

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GSTM1 enzyme concentration and enzyme activity in correlation to the genotype of detoxification enzymes in squamous cell carcinoma of the oral cavity

Abstract: We assume that detoxification enzymes are functionally redundant and that only the simultaneous deficiency of several detoxification enzymes increases the risk for oral cancer.

Cited by 44 publications

References 19 publications

Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review

Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review

CYP1A1, mEH, and GSTM1 Polymophisms and Risk of Oral and Pharyngeal Cancer: A Spanish Case-Control Study

Genetic Polymorphism Related to Oxidative Stress in Autism

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