GSTM1 and GSTT1 Null Genotype Polymorphisms and Susceptibility to Arsenic Poisoning: a Meta-analysis

Jin, Baiming; Wan, Siyuan; Boah, Michael; Yang, Jie; Ma, Wenjing; Lv, Man; Li, Haonan; Wang, Kewei

doi:10.1007/s12011-020-02325-2

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…As also reported by other authors, in the present study, the GSTM1 and GSTT1 null genotypes were both associated with more DNA strand breaks in the univariate analysis. The GSTM1 null genotype has been suggested as a potential susceptibility biomarker to identify people who are not prone to arsenic poisoning (Jin et al, 2021). However, in our study, once adjustments were made for lithium exposure and for the time lag (in days) between sampling and the comet assay in the lab, GSTM1 and GSTT1 genotypes were no longer statistically associated in the multivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

“…The aim of the present cross‐sectional study was to evaluate the potential genotoxic effects of exposure to arsenic, considering simultaneous exposure to lithium and boron, as well as genetic susceptibility. We also assessed genetic variation in AS3MT and analyzed gene deletions involving the glutathione S‐transferases GSTM1 and GSTT1 that have previously been correlated with increased genotoxicity linked to arsenic exposure (Fuciarelli et al, 2009; Jin et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Genotoxicity in humans exposed to arsenic, lithium, and boron in drinking water in the Bolivian Andes—A cross sectional study

Tirado,

Mamani,

De Loma

et al. 2024

Environ and Mol Mutagen

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Elevated concentrations of arsenic, lithium and boron in drinking water have already been reported in Bolivia. Arsenic is known to cause genotoxicity but that caused by lithium and boron is less well known. The aim of the present cross‐sectional study was to evaluate potential genotoxic effects of exposure to arsenic, while considering exposure to lithium and boron and genetic susceptibility. Women (n = 230) were recruited in villages located around Lake Poopó. Exposure to arsenic was determined as the sum of concentrations of arsenic metabolites inorganic arsenic, monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) in urine. Exposure to lithium and boron was determined based on their concentrations in urine. Genetic susceptibility was determined by GSTM1 (glutathione S‐transferase‐mu‐1) and GSTT1 (glutathione S‐transferase‐theta‐1) null genotypes and AS3MT (Arsenite Methyltransferase) rs3740393. Genotoxicity was measured in peripheral blood leukocytes using the comet assay. The geometric means of arsenic, lithium, and boron concentrations were 68, 897, and 3972 μg/L, respectively. GSTM1 and GSTT1 null carriers had more DNA strand breaks than gene carriers (p = .008, p = .005). We found no correlation between urinary arsenic and DNA strand breaks (rS = .03, p = .64), and only a weak non‐significant positive association in the adjusted multivariate analysis (β = .09 [−.03; .22], p = .14). Surprisingly, increasing concentrations of lithium in urine were negatively correlated with DNA strand breaks (rS = −.24, p = .0006), and the association persisted in multivariate analysis after adjusting for arsenic (β = −.22 [−.36; −.08], p = .003). We found no association between boron and DNA strand breaks. The apparent protective effect of lithium merits further investigation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genotoxicity in humans exposed to arsenic, lithium, and boron in drinking water in the Bolivian Andes—A cross sectional study

Tirado,

Mamani,

De Loma

et al. 2024

Environ and Mol Mutagen

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Strengthened arsenic adsorption over Ni-modified γ-Al2O3 under different operation conditions: An experimental and simulation study

Wang

2022

Chemical Engineering Journal

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The Relationship Between GSTT1, GSTM1, GSTO1, GSTP1 and MTHFR Gene Polymorphisms and DNA Damage of BRCA1 and BRCA2 Genes in Arsenic-Exposed Workers

Qian¹,

Tan²,

Zhou³

et al. 2021

Journal of Occupational &Amp; Environmental Medicine

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Objective: To investigate the associations between genetic polymorphisms of GSTT1, GSTM1, GSTO1, GSTP1 and MTHFR genes and the DNA damage levels of BRCA1 and BRCA2 genes. Methods: Peripheral blood samples were used to measure DNA damage levels and genetic polymorphisms, and urine samples were collected to analyze arsenic metabolites in 79 arsenic-exposed workers and 24 non–arsenic-exposed workers. Results: The BRCA1 and BRCA2 damage levels in exposure group were significantly higher than that in control group. Significant associations were detected between GSTT1 and GSTO1 polymorphisms and DNA damage levels of BRCA1 and BRCA2 genes in subjects (P < 0.05). Conclusions: Our findings suggest that the DNA damage levels of BRCA1 and BRCA2 genes may modulate by genetic variations of GSTT1 and GSTO1 when individuals are exposed to carcinogens, such as arsenic.

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GSTM1 and GSTT1 Null Genotype Polymorphisms and Susceptibility to Arsenic Poisoning: a Meta-analysis

Cited by 4 publications

References 39 publications

Genotoxicity in humans exposed to arsenic, lithium, and boron in drinking water in the Bolivian Andes—A cross sectional study

Genotoxicity in humans exposed to arsenic, lithium, and boron in drinking water in the Bolivian Andes—A cross sectional study

Strengthened arsenic adsorption over Ni-modified γ-Al2O3 under different operation conditions: An experimental and simulation study

The Relationship Between GSTT1, GSTM1, GSTO1, GSTP1 and MTHFR Gene Polymorphisms and DNA Damage of BRCA1 and BRCA2 Genes in Arsenic-Exposed Workers

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