“…1 Glycogen synthase kinase-3 inhibitor have been studied as a potential therapeutic agents in depression, anxiety, schizophrenia, Alzheimer's disease, supranuclear palsy, fragile X syndrome, multiple sclerosis, Parkinson's disease, Huntington's disease, stroke, traumatic brain injury, spinocerebellar ataxia type 1, sepsis, asthma, arthritis, colitis, peritonitis and various types of cancers. 2 These drugs have the capacity to modulate human stem cells in vivo. Tideglusib, a glycogen synthase kinase-3 inhibitor, initially tested for its role in Alzheimer's disease and psychiatric disorders, has the potential to change the conventional treatment of dental caries owing to its property to regrow dentine to fill a void.…”