GSH‐Depleted Nanozymes with Hyperthermia‐Enhanced Dual Enzyme‐Mimic Activities for Tumor Nanocatalytic Therapy

Dong, Seung Myung; Dong, Yushan; Jia, Tao; Liu, Shikai; Liu, Jing; Yang, Dan; He, Fei; Gai, Shili; Yang, Piaoping; Lin, Jun

doi:10.1002/adma.202002439

Cited by 405 publications

(328 citation statements)

References 58 publications

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“…Generally, the size of nanoparticle directly determines the relative amounts of cerium ions Ce 3+ and Ce 4+ , and the proportion of Ce 3+ ions in CeO 2 NPs increases with the decrease of particle size. [ 5,6 ] However, the ultrasmall CeO 2 NP nanozymes are vulnerable to aggregation and then the nanozyme activities are dramatically reduced. [ 6 ] Therefore, the stability and aggregation of ultrasmall CeO 2 NPs are very significant for improving their enzyme‐like activities.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Graphdiyne–Cerium Oxide Nanozymes Facilitate MicroRNA Delivery and Attenuate Tumor Hypoxia for Highly Efficient Radiotherapy of Esophageal Cancer

et al. 2021

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Radioresistance is an important challenge for clinical treatments. The main causes of radioresistance include hypoxia in the tumor microenvironment, the antioxidant system within cancer cells, and the upregulation of DNA repair proteins. Here, a multiple radiosensitization strategy of high‐Z‐element‐based radiation enhancement is designed, attenuating hypoxia and microRNA therapy. The novel 2D graphdiyne (GDY) can firmly anchor and disperse CeO2 nanoparticles to form GDY–CeO2 nanocomposites, which exhibit superior catalase‐mimic activity in decomposing H2O2 to O2 to significantly alleviate tumor hypoxia, promote radiation‐induced DNA damage, and ultimately inhibit tumor growth in vivo. The miR181a‐2‐3p (miR181a) serum levels in patients are predictive of the response to preoperative radiotherapy in locally advanced esophageal squamous cell carcinoma (ESCC) and facilitate personalized treatment. Moreover, miR181a can act as a radiosensitizer by directly targeting RAD17 and regulating the Chk2 pathway. Subsequently, the GDY–CeO2 nanocomposites with miR181a are conjugated with the iRGD‐grafted polyoxyethylene glycol (short for nano‐miR181a), which can increase the stability, efficiently deliver miR181a to tumor, and exhibit low toxicity. Notably, nano‐miR181a can overcome radioresistance and enhance therapeutic efficacy both in a subcutaneous tumor model and human‐patient‐derived xenograft models. Overall, this GDY–CeO2 nanozyme and miR181a‐based multisensitized radiotherapy strategy provides a promising therapeutic approach for ESCC.

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Section: Introductionmentioning

confidence: 99%

Multifunctional Graphdiyne–Cerium Oxide Nanozymes Facilitate MicroRNA Delivery and Attenuate Tumor Hypoxia for Highly Efficient Radiotherapy of Esophageal Cancer

et al. 2021

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“…[ 34–39 ] High valence manganese as a simulated catalase has been applied for alleviating tumor hypoxia by decomposing H 2 O 2 to produce H 2 O and O 2 , which could also catalyze the transformation of reduced GSH into oxidized glutathione (GSSG) providing its properties of glutathione peroxidase. [ 40 ]…”

Section: Introductionmentioning

confidence: 99%

Recent Development on Controlled Synthesis of Mn‐Based Nanostructures for Bioimaging and Cancer Therapy

Ruan

Qian

2021

Advanced Therapeutics

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Manganese‐based nanomaterials have emerged as potential and important nanomedicine for bioimaging and cancer treatment due to their excellent electronic structure and intrinsic physiochemical property and sensitivity to tumor microenvironment (TME). In this review, the recent progress on the synthesis and applications of various manganese oxides, sulfides with well‐controlled size, morphologies, chemical composition, and nanostructures have been summarized. Numerous samples have been chosen as examples to demonstrate the as‐designed Mn‐based nanostructures for their specifically responded to the TME to produce highly toxic reactive oxygen species via Fenton‐like reactions. Some advanced nanotechnology has been widely used to enhance their therapeutic performance on the cancer treatment under external physical field for multimodal imaging and cancer therapy including chemodynamic therapy, photodynamic therapy, sonodynamic therapy, photothermal therapy, radiation therapy, starving therapy, and gas therapy. Perspectives have been presented to demonstrate in this cutting‐edge research area.

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“…Various Fe-doped nanoplatforms have been reported to catalyze the conversion of endogenous H 2 O 2 to O 2 and thus could enhance the therapeutic effects against hypoxic tumor, including Fe-doped polydiaminopyridine nanofusiforms (Fe-PDAP) (Bai et al, 2018), Fe III doped C 3 N 4 nanosheets , and Fe 3+ -driven assembly of fluorenylmethyloxycarbonyl (Fmoc) protected amino acids (Fmoc-Cys/Fe) . Lan et al (2018) Prussian blue (PB), a clinical medicine approved by U.S. FDA for the treatment of radioactive exposure, has been proven with catalase-like activity (Cai et al, 2016;Zhou et al, 2018 (Dong et al, 2020), RuO 2 (Huang et al, 2020;Xu et al, 2020), V 2 O 5 , mesoporous manganese cobalt oxide derived from MOFs (Wang et al, 2019), Pd@Pt nanoplates (Wei et al, 2018), gold nanoclusters (Liu, C. P., et al, 2017), MOF-Au nanohybrid (He et al, 2019), Pt nanoparticles decorated on MOFs (Zhang et al, 2018), Pt-based core-shell nanoplatform (Wang X. S. et al, 2018), two-dimensional Pd@Au bimetallic core-shell nanostructure , etc. By taking the advantage of dual enzyme-mimic catalytic activity of ultrasmall CeO 2 , Dong et al (2020) fabricated a nanocomposite with hyperthermiaenhanced peroxidase-like activity, catalase-mimic activity, and GSH depletion for efficient tumor therapy in the NIR-II window.…”

Section: Hydrolysis Of Exogenous Peroxide To Produce Omentioning

confidence: 99%

“…Lan et al (2018) Prussian blue (PB), a clinical medicine approved by U.S. FDA for the treatment of radioactive exposure, has been proven with catalase-like activity (Cai et al, 2016;Zhou et al, 2018 (Dong et al, 2020), RuO 2 (Huang et al, 2020;Xu et al, 2020), V 2 O 5 , mesoporous manganese cobalt oxide derived from MOFs (Wang et al, 2019), Pd@Pt nanoplates (Wei et al, 2018), gold nanoclusters (Liu, C. P., et al, 2017), MOF-Au nanohybrid (He et al, 2019), Pt nanoparticles decorated on MOFs (Zhang et al, 2018), Pt-based core-shell nanoplatform (Wang X. S. et al, 2018), two-dimensional Pd@Au bimetallic core-shell nanostructure , etc. By taking the advantage of dual enzyme-mimic catalytic activity of ultrasmall CeO 2 , Dong et al (2020) fabricated a nanocomposite with hyperthermiaenhanced peroxidase-like activity, catalase-mimic activity, and GSH depletion for efficient tumor therapy in the NIR-II window. Huang et al (2020) reported that a multifunctional artificial metalloprotein nanoanalogue, RuO 2 -hybridized ovalbumin (OVA) nanoanalogues, not only exhibited photothermal/ photodynamic effect under NIR light irradiation but also effectively alleviated tumor hypoxia via catalysis of intracellular H 2 O 2 to produce O 2 , thereby concurrently enhancing PDT and reversing the immunosuppressive TME.…”

Section: Hydrolysis Of Exogenous Peroxide To Produce Omentioning

confidence: 99%

Nanomaterials for Tumor Hypoxia Relief to Improve the Efficacy of ROS-Generated Cancer Therapy

Ruan

Dongmin

et al. 2021

Front. Chem.

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Given the fact that excessive levels of reactive oxygen species (ROS) induce damage to proteins, lipids, and DNA, various ROS-generating agents and strategies have been explored to induce cell death and tumor destruction by generating ROS above toxic threshold. Unfortunately, hypoxia in tumor microenvironment (TME) not only promotes tumor metastasis but also enhances tumor resistance to the ROS-generated cancer therapies, thus leading to ineffective therapeutic outcomes. A variety of nanotechnology-based approaches that generate or release O2 continuously to overcome hypoxia in TME have showed promising results to improve the efficacy of ROS-generated cancer therapy. In this minireview, we present an overview of current nanomaterial-based strategies for advanced cancer therapy by modulating the hypoxia in the TME and promoting ROS generation. Particular emphasis is put on the O2 supply capability and mechanism of these nanoplatforms. Future challenges and opportunities of design consideration are also discussed. We believe that this review may provide some useful inspiration for the design and construction of other advanced nanomaterials with O2 supply ability for overcoming the tumor hypoxia-associated resistance of ROS-mediated cancer therapy and thus promoting ROS-generated cancer therapeutics.

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GSH‐Depleted Nanozymes with Hyperthermia‐Enhanced Dual Enzyme‐Mimic Activities for Tumor Nanocatalytic Therapy

Abstract: As prospective alternatives for natural enzymes, catalytically active nanomaterials, known as "nanozymes" have attracted considerable interest over the past decade owing to their obvious

Cited by 405 publications

References 58 publications

Multifunctional Graphdiyne–Cerium Oxide Nanozymes Facilitate MicroRNA Delivery and Attenuate Tumor Hypoxia for Highly Efficient Radiotherapy of Esophageal Cancer

Multifunctional Graphdiyne–Cerium Oxide Nanozymes Facilitate MicroRNA Delivery and Attenuate Tumor Hypoxia for Highly Efficient Radiotherapy of Esophageal Cancer

Recent Development on Controlled Synthesis of Mn‐Based Nanostructures for Bioimaging and Cancer Therapy

Nanomaterials for Tumor Hypoxia Relief to Improve the Efficacy of ROS-Generated Cancer Therapy

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