Grunting in a Genetically Modified Minipig Animal Model for Huntington’s Disease –   Pilot Experiments

Tykalová, Tereza; Hlavnička, Jan; Macakova, Monika; Baxa, Monika; Čmejla, Roman; Motlı́k, Jan; Klempíř, Jiří; Rusz, Ján

doi:10.14735/amcsnn20152s61

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Behavioural Motoric and Cognitive Studies1

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2017

2024

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“…Pigs have similar articular organs as humans, and thus, similar motor disturbances like rigidity, chorea and bradykinesia can be expected. A preliminary data and the experiment set-up were published [69]. We observed three types of grunting:…”

Section: Behavioural Motoric and Cognitive Studiesmentioning

confidence: 99%

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Porcine Model of Huntington's Disease

Rausova¹,

Vochozková²,

Vidinská³

et al. 2017

Huntington's Disease - Molecular Pathogenesis and Current Models

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At present, we are probably the only research facility to be breeding transgenic Huntington's disease minipigs (TgHD). These minipigs express N-terminal part of human mutated huntingtin including 124Q under the control of human huntingtin promoter. The founder animal, born in 2009, gave birth to four subsequent generations with an equal contribution of wild-type (WT) and transgenic (TgHD) piglets in all litters. We take different approaches, some of which are unique for large animal models, to study the phenotype development comparing WT and TgHD siblings. In this chapter, we review these approaches and the phenotype progression in the minipigs. Additionally, we outline perspectives in generation of new models using novel methodology and the potential of pig models in preclinical HD studies.

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Section: Behavioural Motoric and Cognitive Studiesmentioning

confidence: 99%

“…Rapidly repeated grunts-appear to have either a greeting or threat function [69]. Several minutes long recordings of different grunting were taped, and the results will be analysed using acoustic software Praat used in evaluation of humans [70].…”

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confidence: 99%