Grundsätzliches zur Steinach-Operation

The Effect of X-Rays of 1000r on Male Germ Cells in the Mouse, With Particular Attention to the Difference in X-Ray Sensitivity of Spermatogonia

“…Regaud and Dubreuil (1908) also found that certain level of radiation dose could damage all spermatogonia without injuring the more matured germ cells. Schinz and Slotopolsky (1925), Desjardins (1932), von Wattenwyl and Joel (1941a, Heller (1948) and Fogg and Cowing (1951a, b) indicated that the spermatogonia might be the most radiosensitive germ cells. The results of the present experiment also have revealed a high sensitivity of spermatogonia on the basis that they begin to disappear rapidly after irradiation, while spermatocytes, spermatids and spermatozoa decrease gradually afterward.…”

“…after X-irradiation has been ascribed to the reconstitution of the germinal epithelium from three different types of cells : (1) Sertoli cells (Schinz and Slotopolsky 1925), (2) undifferentiated cells (Regaud 1910;Oslund and Bachem 1926;Heller 1948) and (3) uninjured spermatogonia (Regaud and Dubreuil 1908;Regaud and Lacassagne 1927;Hertwig 1938;Forroux, Regaud and Samssonow 1938;Schaef er 1939;Henshaw 1944;Fogg and Cowing 1951a, b;Shaver 1953). The participation of Sertoli cells in this process seems least likely since their nuclei are seldom in mitotic division.…”