2022
DOI: 10.21037/atm-22-2798
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GRSF1 predicts an unfavorable prognosis and promotes tumorigenesis in lung adenocarcinoma based on bioinformatics analysis and in vitro validation

Abstract: Background Effective biomarkers play a critical role in improving clinical approaches to treat lung adenocarcinoma (LUAD). However, many existing biomarkers have limitations due to a lot of factors, requiring the development of additional biomarkers to effectively predict the disease course and prognosis of LUAD. Guanine-rich RNA sequence binding factor 1 (GRSF1) participates in multiple biological processes, but its regulatory effect on LUAD remains unknown. The present study aimed to investigate… Show more

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Cited by 2 publications
(1 citation statement)
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References 36 publications
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“…Wei et al found that EHD2 can inhibit the invasive ability of LUAD, improve patient prognosis, and can be used as a prognostic biomarker for LUAD [30]. Huang et al showed through bioinformatics analysis and cellular experiments that high expression of GRSF1 promotes the occurrence and development of LUAD tumors and can be used as an e ective prognostic biomarker for LUAD patients [31]. Previous studies have shown that CMIP, as an oncogene, promotes the progression of human Evidence-Based Complementary and Alternative Medicine gastric cancer and human glioma, and may be a potential target for the diagnosis and treatment of human glioma [18,32].…”
Section: Discussionmentioning
confidence: 99%
“…Wei et al found that EHD2 can inhibit the invasive ability of LUAD, improve patient prognosis, and can be used as a prognostic biomarker for LUAD [30]. Huang et al showed through bioinformatics analysis and cellular experiments that high expression of GRSF1 promotes the occurrence and development of LUAD tumors and can be used as an e ective prognostic biomarker for LUAD patients [31]. Previous studies have shown that CMIP, as an oncogene, promotes the progression of human Evidence-Based Complementary and Alternative Medicine gastric cancer and human glioma, and may be a potential target for the diagnosis and treatment of human glioma [18,32].…”
Section: Discussionmentioning
confidence: 99%