Growth velocity and biological variables during puberty in achondroplasia

Pino, Mariana del; Fano, Virginia; Adamo, Paula

doi:10.1515/jpem-2017-0471

Cited by 22 publications

(19 citation statements)

References 18 publications

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“…A total of 27 out of 385 children, 17 girls and 10 boys, provided sufficient data to analyse growth. Some anthropometric data of these patients were published previously [10,12].…”

Section: Samplementioning

confidence: 99%

“…Nevertheless, the inspection of some individual growth patterns by Merker showed a clear acceleration in growth velocity during early pubertal ages [9]. However, as a result of longitudinal design studies, del Pino et al [2018] showed that ACH adolescents experience a period of rapid increase of height growth velocity with a later slowdown, the "adolescent growth spurt" [12]. In all periods, the ACH growth curve was similar in shape but lesser in magnitude in comparison to the general population [4,5,10,12].…”

Section: Introductionmentioning

confidence: 99%

“…However, as a result of longitudinal design studies, del Pino et al [2018] showed that ACH adolescents experience a period of rapid increase of height growth velocity with a later slowdown, the "adolescent growth spurt" [12]. In all periods, the ACH growth curve was similar in shape but lesser in magnitude in comparison to the general population [4,5,10,12]. Nevertheless, none of these studies included a longitudinal analysis of the whole post-natal growth curve from birth until adulthood.…”

Section: Introductionmentioning

confidence: 99%

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Growth in achondroplasia, from birth to adulthood, analysed by the JPA-2 model

Pino

Fano

Adamo

2020

Journal of Pediatric Endocrinology and Metabolism

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ObjectivesIn general population, there are three phases in the human growth curve: infancy, childhood and puberty, with different main factors involved in their regulation and mathematical models to fit them. Achondroplasia children experience a fast decreasing growth during infancy and an “adolescent growth spurt”; however, there are no longitudinal studies that cover the analysis of the whole post-natal growth. Here we analyse the whole growth curve from infancy to adulthood applying the JPA-2 mathematical model.MethodsTwenty-seven patients, 17 girls and 10 boys with achondroplasia, who reached adult size, were included. Height growth data was collected from birth until adulthood. Individual growth curves were estimated by fitting the JPA-2 model to each individual’s height for age data.ResultsHeight growth velocity curves show that after a period of fast decreasing growth velocity since birth, with a mean of 9.7 cm/year at 1 year old, the growth velocity is stable in late preschool years, with a mean of 4.2 cm/year. In boys, age and peak height velocity in puberty were 13.75 years and 5.08 cm/year and reach a mean adult height of 130.52 cm. In girls, the age and peak height velocity in puberty were 11.1 years and 4.32 cm/year and reach a mean adult height of 119.2 cm.ConclusionsThe study of individual growth curves in achondroplasia children by the JPA-2 model shows the three periods, infancy, childhood and puberty, with a similar shape but lesser in magnitude than general population.

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“…A total of 27 out of 385 children, 17 girls and 10 boys, provided sufficient data to analyse growth. Some anthropometric data of these patients were published previously [10,12].…”

Section: Samplementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Growth in achondroplasia, from birth to adulthood, analysed by the JPA-2 model

Pino

Fano

Adamo

2020

Journal of Pediatric Endocrinology and Metabolism

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“…Because they can modulate light at the nanometer scale, they can generate extremely strong local electromagnetic fields and break the diffraction limit. They have attracted a great deal of research interest [6][7][8][9], and they could be used in unique devices. So far, various plasma devices have been proposed for measuring water content, such as optical filters [10], wavelength demultiplexer [11], and information modulators [12], all of which could be integrated into system-on-a-chip devices.…”

Section: Introductionmentioning

confidence: 99%

Multiple Fano resonances Based on the Rectangular cavity resonator and crescent-shaped cavity resonator

Zhu

Wang

2020

Preprint

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World is rich in unconventional oil and various alternatives to petroleum. However, conventional oil production declines so quickly that it is likely these unconventional oil resources cannot be put into production fast enough, and thus will not be compensated sufficiently. We realize detecting rapid detection of water content in heavy oil. The waveguide consists of a metal-insulator-metal (MIM) waveguide, rectangular cavity resonator, and crescent-shaped cavity resonator. The effects of the coupling distance, geometry of the crescent-shaped cavity resonator and its rotation angle, and length and width of the rectangular cavity resonator on the Fano resonance lines were numerically analyzed. Multiple Fano resonances can be produced as the rotation angle of the crescent-shaped cavity resonator is adjusted, and the sensor’s refractive index sensitivity was found to be \(935.71 \text{n}\text{m}/\text{R}\text{I}\text{U}\). By measuring the water content in heavy oil, we found that the Fano resonance lines shift toward shorter wavelengths as the volume fraction of water content increases. The detection resolution in heavy oil \(1.79\times {10}^{-9}\). The results presented here show that water content in heavy oil can be calculated using the measured change in the Fano resonance wavelength.

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“…In adolescence, del Pino, Fano, and Adamo (2018), showed that ACH males and females, experience an "adolescent growth spurt" and it is similar in shape and half the magnitude of non-ACH population.…”

Section: Introductionmentioning

confidence: 99%

Height growth velocity during infancy and childhood in achondroplasia

Pino

Fano

Adamo

2019

American J of Med Genetics Pt A

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There is a lack of knowledge about longitudinal growth during childhood in achondroplasia. We report patterns of linear growth and height growth velocity references. The sample consisted of 84 children, 41 girls and 43 boys. Growth data was collected from birth until mid-childhood. The median (interquartile range) number of measurements per child was 13.5 (12, 15). Individual growth curves were estimated by fitting the Reed 1st model to each individual's height for age data. Height growth velocities references for age centiles were calculated by LMS method.Mean (SD) birth length was 46.14 cm (2.17) and 45.53 cm (2.16), for boys and girls respectively.Individual growth curves were analyzed. Shifts in growth channels were seen: out of 84 infants, 41 (48.8%) changed more than 1 SDS between birth to 5 years old. The numbers of infants shifting upward were similar (20/84) to the infants shifting downward (21/84). Height growth velocity curves show that after a period of fast decreasing growth velocity since birth, with a mean of 15.5 cm/year and 9.5 cm/year at 6 month and 1 year old, the growth velocity is stable in late preschool years, with a mean of 4.3 cm/year. Shifts in growth channels were seen between birth and 5 years old. Professionals who follow up them must consider this phenomenon during infancy. ACH children experienced a period of fast decreasing growth during infancy and the growth curve was similar in shape and lesser in magnitude than the general population.

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Growth velocity and biological variables during puberty in achondroplasia

Abstract: Children with achondroplasia experienced an adolescent growth spurt, which was similar in shape and half the magnitude of the non-achondroplasia population.

Cited by 22 publications

References 18 publications

Growth in achondroplasia, from birth to adulthood, analysed by the JPA-2 model

Growth in achondroplasia, from birth to adulthood, analysed by the JPA-2 model

Multiple Fano resonances Based on the Rectangular cavity resonator and crescent-shaped cavity resonator

Height growth velocity during infancy and childhood in achondroplasia

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