Growth, serum biochemical, and histopathological responses of broilers administered with silver nanoparticles as a drinking water disinfectant

Kumar, Indrajeet; Bhattacharya, Jayanta; Das, Babulal; Lahiri, Pooja

doi:10.1007/s13205-020-2101-1

“…In parallel with our results, [ 50 ] reported that the silver retention in the liver, spleen, kidney, heart, intestine, and stomach was increased upon the supply of a higher dose of silver. Our results are also supported by [ 51 ], who reported that the higher retention of AgNPs in broiler organs primarily involved the small intestine, followed by the liver tissues. In contrast, [ 26 ] concluded that the accumulation of AgNPs in rat organs was not significant in orally treated rats rather than those with intravenous injection, and asserted that the orally administered AgNPs passed through the gastrointestinal tract and were excreted via the feces without translocation in the bloodstream.…”

Section: Discussionsupporting

confidence: 90%

Silver-Silica nanoparticles induced dose-dependent modulation of histopathological, immunohistochemical, ultrastructural, proinflammatory, and immune status of broiler chickens

Khafaga

¹

,

Fouda

²

,

Alwan

³

et al. 2022

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Silver nanoparticles (AgNPs) are a powerful disinfectant, but little information is available on their potential use as a growth promoter and the safety margin of this. In this study, 480 1-day-old Cobb chicks were assigned to one control and three treated groups. The treated groups were supplemented with silver-doped silica nanoparticles (SiO2@AgNPs) at three dietary levels (8, 16, and 20 mg/kg diet) for 35 days. The results revealed no significant changes in the growth performance and oxidative parameters, and in most of the hematological and biochemical parameters among the control and treated groups. In contrast, dose-dependent adverse effects were exerted on the histopathological structure and immunohistochemical expression of CD45 in liver, kidneys, and lymphoid organs (spleen, bursa, and thymus). In addition, the relative weight of lymphoid organs and the serum levels of immunoglobulins M and G were significantly diminished. Moreover, the gene expression of proinflammatory cytokines (IL-β1 and TNF-α) and the ultrastructural morphology in breast muscle showed significant dose-dependent alterations. It could be concluded that the dietary supplementation of SiO2@AgNPs at a level of 8 mg/kg diet or more has dose-dependent proinflammatory and immunosuppressive effects on broiler chickens.

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“…In parallel with our results, 53 reported that the silver retention in the liver, spleen, kidney, heart, intestine, and stomach was increased upon the supply of a higher dose of silver. Our results are also supported by 54 , who reported that the higher retention of AgNPs in broiler organs primarily involved the small intestine, followed by the liver tissues. In contrast, 27 concluded that the accumulation of AgNPs in rat organs was not signi cant in orally treated rats rather than those with intravenous injection, and asserted that the orally administered AgNPs passed through the gastrointestinal tract and were excreted via the feces without translocation in the bloodstream.…”

Section: Discussionsupporting

confidence: 90%

Silver-Silica Nanoparticles Induced Dose-Dependent Modulation of Histopathological, Immunohistochemical, Ultrastructural, Proinflammatory, and Immune Status of Broiler Chickens

Khafaga

¹

,

Alwan²,

Abdelsalam

³

et al. 2021

Preprint

0

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Silver nanoparticles (AgNPs) are a powerful disinfectant, but little information is available on their potential use as a growth promoter and the safety margin of this. In this study, 480 1-day-old Cobb chicks were assigned to one control and three treated groups. The treated groups were supplemented with silver-doped silica nanoparticles (SiO2@AgNPs) at three dietary levels (8, 16, and 20 mg/kg diet) for 35 days. The results revealed no significant changes in the growth performance and oxidative parameters, and in most of the hematological and biochemical parameters among the control and treated groups. In contrast, dose-dependent adverse effects were exerted on the histopathological structure and immunohistochemical expression of CD45 in liver, kidneys, and lymphoid organs (spleen, bursa, and thymus). In addition, the relative weight of lymphoid organs and the serum levels of immunoglobulins M and G were significantly diminished. Moreover, the gene expression of proinflammatory cytokines (IL-β1 and TNF-α) and the ultrastructural morphology in breast muscle showed significant dose-dependent alterations. It could be concluded that the dietary supplementation of SiO2@AgNPs at a level of 8 mg/kg diet or more has dose-dependent proinflammatory and immunosuppressive effects on broiler chickens.

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“…The improvement could be due to the antimicrobial response of Silver-Nano on harmful intestinal bacteria, improving gut health and the absorption of nutrients as well as stimulating digestive enzyme activity is another proposed reason for the Silver-Nano growth stimulatory effect. Similar results reported after using Silver -Nano at different levels by 25 to 75 ppm (Saleh and El-Magd, 2018;Kumar and Bhattacharya, 2019;Kumar et al, 2020;Bolandi et al, 2021).…”

Section: Effect Of Silver -Nano On Productive Performancesupporting

confidence: 86%

“…Several researchers have illustrated that using Silver nanoparticle (Silver-Nano) in broilers nutrition under optimal conditions either suppress or stimulates growth performance (Saleh and El-Magd, 2018;Kumar and Bhattacharya, 2019;Kumar et al, 2020;Bolandi et al, 2021;Dosoky et al, 2021). Adding Silver -Nano in broilers feeding resulted in enhancement in gut health as noticed by nutrient absorption, increase weight gain, feed conversion ratio and feed intake (Andi et al, 2011).…”

Section: Effect Of Silver -Nano On Productive Performancementioning

confidence: 99%

Applications of biosynthesis of silver nanoparticles for sustainable poultry production under hot climatic conditions. A review

Ahmed

¹

,

Ismail

²

,

Elwerdany

³

et al. 2023

SVU-International Journal of Agricultural Sciences

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A new strategy for the growth of the poultry industry to boost market meat production and overcome the climate change has been developed within the context of Egypt Vision 2030, the country's sustainable development plan. Many infections are present in poultry eggs, which cause embryos to develop prematurely early or hatchlings to death quickly. Immunity of the embryo during embryogenesis is a significant factor influencing the growth of the chicks after hatching. In order to avoid having any negative effects on birds or indirectly on humans, it has become imperative to look for a strategy to increase the bird's immunity beginning at the embryonic Silver before hatching. Silver Nanotechnology feeding alternatives are utilized to promote chicken performance, increase nutritional effectiveness, and modernize some physiological systems and therefore improve economic efficiency. However, consistent results were scarce. The majority of trials indicated only modestly good impacts. There needs to be more research conducted due to the virtually unlimited possibilities for nanotechnology element preparations. To evaluate green nanoparticle and the precise mechanism of action of silver nanoparticles' anti-stress benefits, however, more research is still required under more standardized conditions.

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Growth, serum biochemical, and histopathological responses of broilers administered with silver nanoparticles as a drinking water disinfectant

Cited by 13 publications

References 28 publications

Silver-Silica nanoparticles induced dose-dependent modulation of histopathological, immunohistochemical, ultrastructural, proinflammatory, and immune status of broiler chickens

Silver-Silica nanoparticles induced dose-dependent modulation of histopathological, immunohistochemical, ultrastructural, proinflammatory, and immune status of broiler chickens

Silver-Silica Nanoparticles Induced Dose-Dependent Modulation of Histopathological, Immunohistochemical, Ultrastructural, Proinflammatory, and Immune Status of Broiler Chickens

Applications of biosynthesis of silver nanoparticles for sustainable poultry production under hot climatic conditions. A review

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