Growth Restraint Action of 1,5-Anhydro-D-fructose on Gram-positive Bacteria

Izumi, Shusaku; Yoshinaga, Kazuhiro; Abe, Jun‐ichi

doi:10.5458/jag.jag.jag-2012_007

J. Appl. Glycosci.

2013

DOI: 10.5458/jag.jag.jag-2012_007

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Growth Restraint Action of 1,5-Anhydro-D-fructose on Gram-positive Bacteria

Shusaku Izumi

Kazuhiro Yoshinaga²,

Jun‐ichi Abe

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2023

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“…Furthermore, 1,5-AF is produced as a food material in Japan via the enzymatic degradation of starch. 1,5-AF has antioxidant (5) and antibacterial properties (6) and health benefits (7), thus it has utility as a food preservative and healthy food material.…”

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confidence: 99%

In VivoMetabolism of 1,5-Anhydro-d-fructose to 1,5-Anhydro-d-glucitol

Ijiri

Yoshinaga²,

Kawaguchi

et al. 2023

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Background/Aim: 1,5-Anhydro-D-fructose (1,5-AF, saccharide) and 1,5-anhydro-D-glucitol (1,5-AG) converted from 1,5-AF via the glycemic pathway have health benefits. However, this metabolism has not been sufficiently elucidated. To clarify the in vivo metabolism of 1,5-AF to 1,5-AG, porcine (blood kinetics) and human (urinary excretion) studies were conducted. Materials and Methods: Microminipigs were administrated 1,5-AF orally or intravenously. Blood samples were obtained to analyse the kinetics of 1,5-AF and 1,5-AG. Urine samples were collected from human subjects who had orally ingested 1,5-AF, and the amounts of 1,5-AF and 1,5-AG excreted in the urine were analysed. Results: In blood kinetics analysis, the time to the maximum concentration of 1,5-AF after intravenous administration was 0.5 h, whereas 1,5-AF was not observed after oral administration. The times to the maximum concentration of 1,5-AG after intravenous and oral administration were 1.5 h and 2 h, respectively. In urinary excretion, the concentration of 1,5-AG in urine rapidly increased after the administration of 1,5-AF, peaked at 2 h, whereas 1,5-AF was not detected. Conclusion: 1,5-AF was rapidly metabolized to 1.5-AG in vivo in swine and human.

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confidence: 99%

In VivoMetabolism of 1,5-Anhydro-d-fructose to 1,5-Anhydro-d-glucitol

Ijiri

Yoshinaga²,

Kawaguchi

et al. 2023

In Vivo

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Growth Restraint Action of 1,5-Anhydro-D-fructose on Gram-positive Bacteria

Cited by 1 publication

References 41 publications

In VivoMetabolism of 1,5-Anhydro-d-fructose to 1,5-Anhydro-d-glucitol

In VivoMetabolism of 1,5-Anhydro-d-fructose to 1,5-Anhydro-d-glucitol

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