Growth-related Renal Type II Na/Pi Cotransporter

Segawa, Hiroko; Kaneko, Ichiro; Takahashi, Akira; Kuwahata, Masashi; Ito, Mikiko; Ohkido, Ichiro; Tatsumi, Sawako; Miyamoto, Ken‐ichi

doi:10.1074/jbc.m200943200

Cited by 279 publications

(362 citation statements)

References 27 publications

(48 reference statements)

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“…NaPi-IIc (SLC34A3) was identified from human EST clones (Segawa et al, 2002). Expression of NaPi-IIc was found exclusively in the kidney and proposed to be growth related based on animal studies: in weaning rats it is expressed in the BBM of S1 segments of proximal tubules, but is strongly down-regulated in adult animals Segawa et al, 2002).…”

Section: Napi-iicmentioning

confidence: 99%

“…Expression of NaPi-IIc was found exclusively in the kidney and proposed to be growth related based on animal studies: in weaning rats it is expressed in the BBM of S1 segments of proximal tubules, but is strongly down-regulated in adult animals Segawa et al, 2002). The 75kDa protein is localized at the apical membranes of proximal tubule epithelia of juxtamedullary nephrons (Segawa et al, 2002).…”

Section: Napi-iicmentioning

confidence: 99%

“…They mediate transport with a 3:1 Na + :P i stoichiometry (Forster et al, 1999). The transport kinetics of NaPi-IIc are insensitive to membrane potential, no net charge is translocated and transport is mediated with a 2:1 stoichiometry (Bacconi et al, 2005;Segawa et al, 2002). The stoichiometry difference means that the theoretical P i concentrating capacity is approximately 100-fold higher for NaPi-IIa/b, at the cost of a 10-fold greater inward flux of Na + ions compared to NaPi-IIc, together with net charge movement, both of which must be compensated by the cell through the action of the Na + /K + -ATPase.…”

Section: Kinetics Of Slc34 Proteinsmentioning

confidence: 99%

“…No information is available concerning the localization of the substrate coordination sites. The electroneutral NaPi-IIc (Segawa et al, 2002) provided an important tool to identify the molecular determinants of electrogenicity; in particular 3 critical amino acids essential for Na + binding and charge translocation, conserved in all electrogenic isoforms, were identified by mutagenesis (Bacconi et al, 2005).…”

Section: Structure-function Relationships Of Slc34 Proteinsmentioning

confidence: 99%

“…The expression of NaPi-IIa and NaPi-IIc is limited to the BBM of renal proximal tubules (Custer M, 1994;Segawa et al, 2002). Both transporters together with PiT-2 (see 3.3.1) are responsible for the reabsorption of most of the P i from the primary filtrate.…”

Section: Physiological Pathophysiological and Pharmaceutical Aspectsmentioning

confidence: 99%

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Phosphate transporters of the SLC20 and SLC34 families

Forster

Hernando

Biber

et al. 2013

Molecular Aspects of Medicine

178

198

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Transport of inorganic phosphate (Pi) across the plasma membrane is essential for normal cellular function. Members of two families of SLC proteins (SLC20 and SLC34) act as Na(+)-dependent, secondary-active cotransporters to transport Pi across cell membranes. The SLC34 proteins are expressed in specific organs important for Pi homeostasis: NaPi-IIa (SLC34A1) and NaPi-IIc (SLC34A3) fulfill essential roles in Pi reabsorption in the kidney proximal tubule and NaPi-IIb (SLC34A2) mediates Pi absorption in the gut. The SLC20 proteins, PiT-1 (SLC20A1), PiT-2 (SLC20A2) are expressed ubiquitously in all tissues and although generally considered as "housekeeping" transport proteins, the discovery of tissue-specific activity, regulatory pathways and gene-related pathophysiologies, is redefining their importance. This review summarizes our current knowledge of SLC20 and SLC34 proteins in terms of their basic molecular characteristics, physiological roles, known pathophysiology and pharmacology. AbstractTransport of inorganic phosphate (P i ) across the plasma membrane is essential for normal cellular function. Members of two families of SLC proteins (SLC20 and SLC34) act as Na + -dependent, secondary-active cotransporters to transport P i across cell membranes. The SLC34 proteins are expressed in specific organs important for P i homeostasis: NaPi-IIa (SLC34A1) and NaPi-IIc (SLC34A3) fulfill essential roles in P i reabsorption in the kidney proximal tubule and NaPi-IIb (SLC34A2) mediates P i absorption in the gut. The SLC20 proteins, PiT-1 (SLC20A1), PiT-2 (SLC20A2) are expressed ubiquitously in all tissues and although generally considered as "housekeeping" transport proteins, the discovery of tissue-specific activity,regulatory pathways and gene-related pathophysiologies, is redefining their importance. This review summarises our current knowledge of SLC20 and SLC34 proteins in terms of their basic molecular characteristics, physiological roles, known pathophysiologies and pharmacology.3

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Section: Napi-iicmentioning

confidence: 99%

Section: Napi-iicmentioning

confidence: 99%

Section: Kinetics Of Slc34 Proteinsmentioning

confidence: 99%

Section: Structure-function Relationships Of Slc34 Proteinsmentioning

confidence: 99%

Section: Physiological Pathophysiological and Pharmaceutical Aspectsmentioning

confidence: 99%

See 3 more Smart Citations

Phosphate transporters of the SLC20 and SLC34 families

Forster

Hernando

Biber

et al. 2013

Molecular Aspects of Medicine

178

198

View full text Add to dashboard Cite

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Pseudohypoparathyroidism

Jüppner¹,

Baştepe²

2013

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

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Nonlinear disposition of lithium in rats and saturation of its tubular reabsorption by the sodium‐phosphate cotransporter as a cause

Uwai

Kawasaki

Nabekura

2018

Biopharm & Drug Disp

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We previously reported the contribution of sodium-phosphate cotransporter to the tubular reabsorption of lithium in rats. In the present study, the dose dependency of the renal handling of lithium was examined in rats. When lithium chloride at 1.25 mg/kg, 2.5 mg/kg and 25 mg/kg was intravenously injected as a bolus, the areas under the plasma concentration-time curve of lithium until 60 minutes were calculated to be 6.23 mEq·min/l, 8.77 mEq·min/l and 64.6 mEq·min/l, respectively. The renal clearance of lithium and its fractional excretion increased with increments in the dose administered. The renal clearance of lithium strongly correlated with the urinary excretion rate of phosphate in the 1.25 mg/kg group (r = 0.840) and 2.5 mg/kg group (r = 0.773), whereas this correlation was weak in the 25 mg/kg group (r = 0.306). The infusion of foscarnet, a typical inhibitor of sodium-phosphate cotransporter, decreased the fractional reabsorption of lithium in rats administered lithium chloride at 2.5 mg/kg, but did not affect it in rats administered 25 mg/kg. These results demonstrate the nonlinearity of the renal excretion of lithium in rats, with the saturation of lithium reabsorption by the sodium-phosphate cotransporter potentially being involved.

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Growth-related Renal Type II Na/Pi Cotransporter

Cited by 279 publications

References 27 publications

Phosphate transporters of the SLC20 and SLC34 families

Phosphate transporters of the SLC20 and SLC34 families

Pseudohypoparathyroidism

Nonlinear disposition of lithium in rats and saturation of its tubular reabsorption by the sodium‐phosphate cotransporter as a cause

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