Growth-related lipid peroxidation in tumour microsomal membranes and mitochondria

Bartoli, Gianna Maria; Galeotti, T.

doi:10.1016/0005-2760(79)90249-2

Cited by 103 publications

(26 citation statements)

References 21 publications

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“…Thus in our study the reduced levels of lipid peroxidation in the colon tissue could be attributed to the tumour burden. These results are consistent with our previous reports Sreedharan et al, 2009) and also by others (Bartoli and Galeotti, 1979).…”

Section: Discussionsupporting

confidence: 95%

Biochemical and molecular mechanisms underlying the chemopreventive efficacy of rosmarinic acid in a rat colon cancer

Venkatachalam

Gunasekaran

Nalini

2016

European Journal of Pharmacology

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Section: Discussionsupporting

confidence: 95%

Biochemical and molecular mechanisms underlying the chemopreventive efficacy of rosmarinic acid in a rat colon cancer

Venkatachalam

Gunasekaran

Nalini

2016

European Journal of Pharmacology

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“…Cancer cells are known to have highly evolved protective mechanisms to prevent lipid peroxidation so that rapid cell proliferation can occur [35]. Similar to our present study, several studies have demonstrated that lipid peroxidation is decreased significantly in tumor cells and tissues as compared to that in corresponding normal cells and tissues [36]. Morin supplementation to DMH treated rats throughout the experimental period (group 4) resulted in near normal levels of TBARS, CD and LOOH as compared to DMH alone treated rats (group 3).…”

Section: Discussionsupporting

confidence: 92%

Effect of morin on tissue lipid peroxidation and antioxidant status in 1, 2-dimethylhydrazine induced experimental colon carcinogenesis

Vennila¹,

Venkatachalam²,

Nalini³

2008

Invest New Drugs

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Colon cancer is the third most malignant neoplasm in the world and it remains today an important cause of death, especially in western countries. In this study, we have evaluated the chemopreventive efficacy of morin on tissue lipid peroxidation and antioxidant status, which are used as biomarkers in 1,2-dimethylhydrazine-induced colon carcinogenesis in a rat model. Male Wistar rats were divided into four groups and received high fat diet. Group 1 served as control, groups 2 and 4 were given a daily treatment of morin (50 mg/kg body weight) orally, everyday for a total period of 30 weeks. Groups 3 and 4 were given weekly subcutaneous injections of DMH at a dose of 20 mg/kg body weight in the groin for 15 weeks. Animals were sacrificed at the end of 30 weeks. The liver, intestine, colon and caecum from different groups were subjected to histopathological studies, determination of lipid peroxidation and antioxidant status. Our results showed decreased levels of liver enzymic and non-enzymic antioxidants and increased levels of lipid peroxidation (LPO) products such as tissue thiobarbituricacid substances (TBARS), lipid hydroperoxides (LOOH) and conjugated dienes (CD) in DMH treated rats, which were significantly (P < 0.05) reversed on morin supplementation. Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH treated rats, which were significantly (P < 0.05) elevated on simultaneous morin supplementation. Moreover, enhanced activity of intestinal, colonic and caecal ascorbic acid and alpha-tocopherol levels were also observed in DMH alone treated rats, which were significantly (P < 0.05) reduced on morin supplementation. These results indicate that morin could exert a significant chemopreventive effect on colon carcinogenesis induced by DMH.

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“…The membrane lipids of neoplastic cells are generally low in polyunsaturated fatty acids, particularly the n-6 series [5,6], and this may be accompanied by increased levels of antioxidants [6]. In non-neoplastic cells, high rates of lipid peroxidation occur at interphase and this may regulate cell division [7,8]. By contrast, cancer cells, with increased cell division, exhibit relatively low peroxidation activity.…”

Section: Introductionmentioning

confidence: 96%

“…By contrast, cancer cells, with increased cell division, exhibit relatively low peroxidation activity. This is possibly due to a limited supply of polyunsaturated fatty acid substrates and/or a high antioxidant level [8]. In many of these studies on the inhibitory effects of fatty acids however, tumor cells were not compared with non-neoplastic cells derived from the same tissue [1][2][3][4][5]9].…”

Section: Introductionmentioning

confidence: 99%

Effect of n-6 polyunsaturated fatty acids on growth and lipid composition of neoplastic and non-neoplastic canine prostate epithelial cell cultures

et al. 1997

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Growth-related lipid peroxidation in tumour microsomal membranes and mitochondria

Cited by 103 publications

References 21 publications

Biochemical and molecular mechanisms underlying the chemopreventive efficacy of rosmarinic acid in a rat colon cancer

Biochemical and molecular mechanisms underlying the chemopreventive efficacy of rosmarinic acid in a rat colon cancer

Effect of morin on tissue lipid peroxidation and antioxidant status in 1, 2-dimethylhydrazine induced experimental colon carcinogenesis

Effect of n-6 polyunsaturated fatty acids on growth and lipid composition of neoplastic and non-neoplastic canine prostate epithelial cell cultures

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