Growth rate of human preimplantation embryos is sex dependent after ICSI but not after IVF

Dumoulin, J.C.M.; Derhaag, Josien G.; Bras, M.; Montfoort, Aafke P.A. van; Kester, A.D.M.; Evers, Johannes L.H.; Geraedts, J. P. M.; Coonen, Edith

doi:10.1093/humrep/deh614

Cited by 57 publications

(53 citation statements)

References 65 publications

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“…Dumoulin et al found a clear sex related growth difference in a study on growth rate of human preimplantation surplus blastocysts [10]. The sex related difference was significantly greater in ICSI than in IVF embryos.…”

Section: Discussionmentioning

confidence: 98%

Blastocyst transfer and gender: IVF versus ICSI

Hentemann

Briskemyr

Bertheussen

2009

J Assist Reprod Genet

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Purpose To investigate the difference in sex ratio in our centre after day 5 embryo transfer among neonates delivered after fresh in vitro fertilization (IVF), fresh intra cytoplasmatic sperminjection (ICSI) and frozen embryo replacement (FER) compared to expected sex ratio in normal population. Methods Retrospective data after IVF/ICSI/FER therapy from 1995 -2007 and data from the literature on similar subjects. Results Among a total of 420 births after day 5 transfer, there were 225 male and 195 female babies. However, after ICSI alone 30 were female and 21 male. Adding all available data from the literature on gender ratio after long term culture, the ratio of male births to total births (0.545) was significantly (p=0.004) different from the expected ratio (0.515) Conclusions It appears that significantly more males are born than expected after day 5 transfer in IVF. However, a subgroup analysis in our data comparing IVF, ICSI and FER revealed more females born after ICSI and FER, suggesting that further research is needed in this area.

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Section: Discussionmentioning

confidence: 98%

Blastocyst transfer and gender: IVF versus ICSI

Hentemann

Briskemyr

Bertheussen

2009

J Assist Reprod Genet

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“…The mechanism responsible for the findings remains unknown so far, but according to the study group's hypothesis the ICSI procedure might interfere with the process of imprinted X-inactivation. 179 …”

mentioning

confidence: 99%

The interface between assisted reproductive technologies and genetics: technical, social, ethical and legal issues

et al. 2006

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“…Embryos reaching at least the 5-cell stage on day 3 of development were biopsied by laser zone drilling using an Infrared Diode Laser (Octax Laser Shot System, MTG, Bruckberg, Germany), withdrew the material necessary to biopsy and returned to culture embryos; only one blastomere was removed by embryo. Then samples were by Dumoulin et al, 2005. In situ hybridization was performed using the following probes for chromosomes X, Y, 13, 18 and 21 (PGT Multivision Probe Panel; Vysis, Downers Grove, USA).…”

Section: Resultsmentioning

confidence: 99%