Growth rate of braid monoids MBn+1, n ≤ 5

Iqbal, Zaffar; Yousaf, Shamaila; Noreen, Sadia

doi:10.1063/1.4724166

Cited by 4 publications

(5 citation statements)

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“…One system that seems highly interesting in both wound healing and cancer is the epidermal growth factor receptor (EGFR) and one of its ligands, the epidermal growth factor (EGF). EGFR is known to be involved in several cancer types, because an overproduction or overstimulation of EGFR has a severe impact on the cell cycle by inducing proliferation, survival, and differentiation . Furthermore, a variant of EGFR in humans is described as a favorable marker for breast cancer diagnosis .…”

Section: Introductionmentioning

confidence: 99%

Impact of plasma oxidation on structural features of human epidermal growth factor

Yusupov

Lackmann

Razzokov

et al. 2018

Plasma Processes & Polymers

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We perform computer simulations supported by experiments to investigate the oxidation of an important signaling protein, that is, human epidermal growth factor (hEGF), caused by cold atmospheric plasma (CAP) treatment. Specifically, we study the conformational changes of hEGF with different degrees of oxidation, to mimic short and long CAP treatment times. Our results indicate that the oxidized structures become more flexible, due to their conformational changes and breakage of the disulfide bonds, especially at higher oxidation degrees. MM/GBSA calculations reveal that an increasing oxidation level leads to a lower binding free energy of hEGF with its receptor. These results help to understand the fundamentals of the use of CAP for wound healing versus cancer treatment at short and longer treatment times.

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Section: Introductionmentioning

confidence: 99%

Impact of plasma oxidation on structural features of human epidermal growth factor

Yusupov

Lackmann

Razzokov

et al. 2018

Plasma Processes & Polymers

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“…From the tyrosine kinase receptors in the epidermal growth factor receptor (EGFR) family,H ER2 has an important role in the evolution of severalh uman cancers. [12] As overexpression of HER2 occurs in breast, prostate, gastric/gastroesophageal,o varian, endometrial, bladder,l ung, colon, and head and neckc ancers, it is a target for therapies pointing to inhibition of this protein to de-crease tumor growth. [12] Mutated and overactive HER1 is linked to the initiation of ac ascade of signaling pathways resulting in tumorg rowth and progression.…”

Section: Computational Dockingmentioning

confidence: 99%

“…[12] As overexpression of HER2 occurs in breast, prostate, gastric/gastroesophageal,o varian, endometrial, bladder,l ung, colon, and head and neckc ancers, it is a target for therapies pointing to inhibition of this protein to de-crease tumor growth. [12] Mutated and overactive HER1 is linked to the initiation of ac ascade of signaling pathways resulting in tumorg rowth and progression. [13] This enzymei so verexpressed in many human epithelial malignanciesi ncluding nonsmall cell lung cancer (NSCLC), pancreatic andh epatocellular carcinoma, andc olorectal, breast, ovarian, endometrial, and renal cancer.H ER1 inhibition results in decreased tumor cell migration and invasiveness,a nd induction of apoptosis.…”

Section: Computational Dockingmentioning

confidence: 99%

Deuterated Curcuminoids: Synthesis, Structures, Computational/Docking and Comparative Cell Viability Assays against Colorectal Cancer

et al. 2019

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A series of deuterated curcuminoids (CUR) were synthesized, bearing two to six OCD3 groups, in some cases in combination with methoxy groups, and in others together with fluorine or chlorine atoms. A model ring‐deuterated hexamethoxy‐CUR–BF2 and its corresponding CUR compound were also synthesized from a 2,4,6‐trimethoxybenzaldehyde‐3,5‐d2 precursor. As with their protio analogues, the deuterated compounds were found to remain exclusively in the enolic form. The antiproliferative activities of these compounds were studied by in vitro bioassays against a panel of 60 cancer cell lines, and more specifically in human colorectal cancer (CRC) cells (HCT116, HT29, DLD‐1, RKO, SW837, and Caco2) and in normal colon cells (CCD841CoN). The deuterated CUR–BF2 adducts exhibited better overall growth inhibition by NCI‐60 assay, while for other CUR–BF2 adducts the non‐deuterated analogues were more cytotoxic. Results of the more focused comparative cell viability assays followed the same trend, but with some variation depending on cell lines. The CUR–BF2 adducts exhibited significantly higher cytotoxicity than CURs. Structural studies (X‐ray and DFT) and computational molecular docking calculations comparing their inhibitory efficacy with those of known anticancer agents used in chemotherapy are also reported.

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“…For instance, they might be a proper carrier for delivery of Imatinib, which is a tyrosine kinase inhibitor also known as "Gleevec" or "Glivec". [40] This drug has been loaded onto various NPs for different purposes. For example, it has been loaded onto poly-electrolytic lithium nanocapsules for treatment of chronic leukemia, [41] albumin NPs in treatment of glioblastoma, [42] PVP-modified Au NPs for treatment of melanoma, [43] starch carbon quantum dots for detecting cancer cells [44] and Ag NPs to investigate its effect on breast cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Imatinib‐loaded chitosan‐modified magnetic nanoparticles as an anti‐cancer agent for pH responsive targeted drug delivery

Ghezeli

Hekmati

Veisi

2019

Applied Organom Chemis

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Targeted drug delivery is a promising approach to overcome the limitations of classical chemotherapy. In this respect, Imatinib‐loaded chitosan‐modified magnetic nanoparticles were prepared as a pH sensitive system for targeted delivery of drug to tumor sites by applying a magnetic field. The proposed magnetic nanoparticles were prepared through modification of magnetic Fe3O4 nanoparticles with chitosan and Imatinib. The structural, morphological and physicochemical properties of the synthesized nanoparticles were determined by different analytical techniques including energy‐dispersive X‐ray spectroscopy (EDS), field emission scanning electron microscopy (FESEM), Fourier‐transform infrared (FTIR) spectroscopy, high resolution transmission electron microscopy (HR‐TEM), vibrating sample magnetometry (VSM), X‐ray diffraction (XRD) and X‐ray photoelectron spectroscopy (XPS). UV/visible spectrophotometry was used to measure the Imatinib contents. Thermal stability of the prepared particles was investigated and their efficiency of drug loading and release profile were evaluated. The results demonstrated that Fe3O4@CS acts as a pH responsive nanocarrier in releasing the loaded Imatinib molecules. Furthermore, the Fe3O4@CS/Imatinib nanoparticles displayed cytotoxic effect against MCF‐7 breast cancer cells. Results of this study can provide new insights in the development of pH responsive targeted drug delivery systems to overcome the side effects of conventional chemotherapy.

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Growth rate of braid monoids MBn+1, n ≤ 5

Cited by 4 publications

References 0 publications

Impact of plasma oxidation on structural features of human epidermal growth factor

Impact of plasma oxidation on structural features of human epidermal growth factor

Deuterated Curcuminoids: Synthesis, Structures, Computational/Docking and Comparative Cell Viability Assays against Colorectal Cancer

Synthesis of Imatinib‐loaded chitosan‐modified magnetic nanoparticles as an anti‐cancer agent for pH responsive targeted drug delivery

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