Growth performance, tissue precipitation, metallothionein and cytokine transcript expression and economics in response to different dietary zinc sources in growing rabbits

Hassan, Fardos A.M.; Kishawy, Asmaa T. Y.; Moustafa, Amira; Roushdy, Elshimaa M.

doi:10.1111/jpn.13550

Cited by 4 publications

(5 citation statements)

References 54 publications

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“…In the present study, only ZnO reduced serum IL-1β level of 28-day-old calves compared with the CON group. This is similar to a previous study in growing rabbits [11], in which supplementary 50 mg/d ZnPro did not affect serum IL-1β concentration. IL-10 has protective effects on the intestinal mucosal barrier [29].…”

Section: Discussionsupporting

confidence: 92%

“…Zinc can be transferred into the circulatory system through MT during intestinal absorption, so MT can regulate Zn balance and metabolism in the body [11,37]. In addition, an MT molecule can combine with seven Zn ions to scavenge ROS in liver and bone marrow cells; its scavenging ability of •OH is 300-fold greater than GSH-Px [38].…”

Section: Discussionmentioning

confidence: 99%

“…Zinc (Zn) is an essential nutrient element and is involved in many physiological functions in the body [9]. Supplementary Zn has increased growth performance, promoted antioxidant and immune activities, improved intestinal microflora, and reduced the incidence of diarrhea [10,11]. Zinc proteinate (ZnPro) is a novel form of organic Zn prepared from soybean protein isolate and feed-grade inorganic Zn [12].…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Zinc Supplementation on Growth, Diarrhea, Antioxidant Capacity, and Immune Function in Holstein Dairy Calves

Liu

Degen

et al. 2023

Animals

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The current study examined the effects of supplementary zinc proteinate (ZnPro) and zinc oxide (ZnO) on growth performance, diarrhea, antioxidant capacity, immune function, and mineral element concentrations of calves aged 1 to 28 days. A total of twenty-four newborn calves were divided randomly into 3 groups (n = 8; 2 males and 6 females per group), and each received: 0 mg/d Zn (CON), 627 mg/d ZnPro (80 mg/d Zn; ZnPro group), and 101 mg/d ZnO (80 mg/d Zn; ZnO group). The calves received the additive in their milk during the first 28 days of life. Compared with the CON group: ZnPro and ZnO improved average daily gain (ADG) and decreased the feed:gain ratio (FGR) between days 1 and 14 (p < 0.05), while the ADG increased and FGR decreased only in the ZnPro group between days 1 and 28 (p < 0.05). The incidence of diarrhea decreased (p < 0.05) in the ZnPro and ZnO groups between days 15 and 28 as well as days 1 and 28, but decreased (p < 0.05) only in the ZnPro group between days 1 and 14. The serum immunoglobulin G (IgG) concentration of the ZnPro and ZnO groups increased on days 14 and 28 (p < 0.05). ZnPro supplementation increased serum IgM concentration during the whole study, while ZnO enhanced serum IgM concentration only on day 14 (p < 0.05). In the ZnO group, the serum concentration of cytokines interleukin (IL)-10 increased on day 14, while that of IL-1β increased on day 28 (p < 0.05). In addition, ZnPro reduced the serum malondialdehyde (MDA) concentration on days 14 and 28 (p < 0.05). Both ZnPro and ZnO increased the serum concentrations of alkaline phosphatase (ALP) and metallothionein (MT) on day 14 (p < 0.05). With zinc supplementation, plasma Zn concentration increased (p < 0.05) on days 14 and 28 of age. We concluded that supplementary ZnPro and ZnO reduced incidences of diarrhea and promoted the immune function, but ZnPro improved the growth performance and antioxidant capacity of Holstein dairy calves to a greater extent.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effects of Zinc Supplementation on Growth, Diarrhea, Antioxidant Capacity, and Immune Function in Holstein Dairy Calves

Liu

Degen

et al. 2023

Animals

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“…Zinc is an essential trace mineral for humans and animals with effective antidiarrheal and growth promotion activities ( 28 , 29 ). Lower doses of zinc, especially in organic forms, can reduce diarrhea and promote the growth of young animals ( 10 , 15 , 25 ). In agreement with these findings, the present study found that dietary supplementation with ZnP linearly increased total DMI, ADG, and feed efficiency, thus increasing the final BW of preweaned dairy calves.…”

Section: Discussionmentioning

confidence: 99%

“…Zinc is an essential nutrient element and is involved in many physiologic functions in the body (7). Dietary zinc supplementation has been found to increase growth performance, promote antioxidant and immune activities, improve the intestinal microflora, and reduce the incidence of diarrhea (8)(9)(10). Although oral administration of large amounts of zinc oxidant (ZnO) was often used to promote growth and reduce diarrhea in young animals (11), unabsorbed zinc secreted in feces may post a threat to the environment.…”

Section: Introductionmentioning

confidence: 99%

Early supplementation with zinc proteinate does not change rectal microbiota but increases growth performance by improving antioxidant capacity and plasma zinc concentration in preweaned dairy calves

Liu,

Yu,

et al. 2023

Front. Vet. Sci.

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The present study evaluated the effects of early supplementation with zinc proteinate (ZnP) or zinc oxide (ZnO) for 2 weeks on the growth performance, redox status, plasma trace element concentrations, and rectal microbiota of preweaned dairy calves. A total of 60 newborn healthy female Holstein dairy calves, with initial body weight (BW): 41.33 ± 0.62 kg, were randomly allocated to 5 groups of 12 each: a control group (CON); three groups supplemented with 261 (L-ZnP), 523 (M-ZnP), and 784 (H-ZnP) mg/day ZnP, equivalent to 40, 80, and 120 mg/day zinc, respectively; and one group supplemented with 232 mg/day ZnO, equivalent to 180 mg/day zinc (ZnO). Zinc supplements were administered on days 1–14, and the calves were followed up until day 70. Zinc supplementation increased total dry matter intake (DMI) and starter DMI compared with the CON group (p < 0.01). The final BW, average daily gain, and feed efficiency were higher in the M-ZnP, H-ZnP, and ZnO groups (p < 0.05). The incidence of diarrhea on days 1–28 was reduced by zinc administration (p < 0.01), whereas the incidence on days 29–56 was lower in the M-ZnP and ZnO groups (p < 0.05). Serum glutathione peroxidase activity, total antioxidant capacity, immunoglobulin G and plasma zinc concentrations were increased linearly (p < 0.05), while the serum concentration of malondialdehyde was decreased linearly (p < 0.01), as the dose of ZnP increased. ZnP yielding 80 mg/day zinc had similar effects as ZnO yielding 180 mg/day zinc, except that final BW was higher in the ZnO group (p < 0.05). At the phylum level, ZnO decreased the relative abundance of Firmicutes while increasing the abundance of Bacteroidetes (p < 0.05). At the genus level, ZnO increased the relative abundances of Prevotella, Subdoligranulum, and Odoribacter (p < 0.05). These findings indicated that early supplementation with ZnP did not affect the rectal microbiota of preweaned dairy calves but increased their growth performance, antioxidant capacity, and plasma zinc concentration. In summary, ZnP is an organic zinc source with greater bioavailability than ZnO for preweaned dairy calves. Early dietary supplementation with ZnP yielding 80 mg/day zinc is recommended.

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Nanominerals: A Climate Smart Tool in Livestock Feeding—A Review

Swain,

Rao,

Rajendran

et al. 2023

The Palgrave Handbook of Socio-Ecological Resilience in the Face of Climate Change

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Growth performance, tissue precipitation, metallothionein and cytokine transcript expression and economics in response to different dietary zinc sources in growing rabbits

Abstract: Multidrug resistance bacteria are considered a public health threat.Several previous studies revealed the emergence of multidrugresistant bacterial pathogens from different origins that increase the need for dietary supplements to improve animal immunity

Cited by 4 publications

References 54 publications

The Effects of Zinc Supplementation on Growth, Diarrhea, Antioxidant Capacity, and Immune Function in Holstein Dairy Calves

The Effects of Zinc Supplementation on Growth, Diarrhea, Antioxidant Capacity, and Immune Function in Holstein Dairy Calves

Early supplementation with zinc proteinate does not change rectal microbiota but increases growth performance by improving antioxidant capacity and plasma zinc concentration in preweaned dairy calves

Nanominerals: A Climate Smart Tool in Livestock Feeding—A Review

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