Growth pattern and expressions of cell cycle regulator proteins p53 and p21WAF1/CIP1 in early gastric carcinoma

Noda, Hiroshi; Maehara, Yoshihiko; Irie, Koji; Kakeji, Yoshihiro; Yonemura, Tomohiro; Sugimachi, Keizō

doi:10.1002/1097-0142(20011001)92:7<1828::aid-cncr1699>3.0.co;2-q

Cited by 20 publications

(20 citation statements)

References 80 publications

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“…It has been reported that p21 waf1 mediates the growth response to TGF-β in human epithelial cells and that the absence of p21 waf1 may be one method used by cancer cells to escape the growth inhibitory effects of TGF-β (36). The fact that high p21 waf1 expression significantly correlates with poorer clinical outcome is in agreement with previous studies conducted on carcinomas, such as prostate carcinoma (37), superficial bladder tumors (38) and gastric carcinoma (39). The opposite results have also been reported from studies of several other types of tumor, including breast (40), lung (41) and laryngeal (42) carcinoma.…”

Section: Discussionsupporting

confidence: 90%

Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue

et al. 2015

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Abstract. Esophageal squamous cell carcinoma (SCC) possesses one of the worst prognoses out of the digestive carcinomas. Several studies have suggested that transforming growth factor β receptor type II (TGF-βRII), Smad family member 4 (Smad4) and p21 wild-type p53-activated factor 1 (p21 waf1 ) are associated with esophageal SCC. The aim of the present study was to evaluate the effect of Smad4, TGF-βRII and p21 waf1 in esophageal squamous cancer tissue and the pathological significance of the effect. An immunohistochemical method was used to evaluate the expression levels of Smad4, TGF-βRII and p21 waf1 in specimens of esophageal SCC lesions obtained from 80 patients. It was found that the expression of Smad4, TGF-βRII and p21 waf1 in histologically-classified grade I esophageal SCC, without invasion or lymph node metastasis, was markedly higher compared with grade III esophageal SCC that had invaded into the deep muscular or serous layer and metastasized to the lymph nodes (P<0.05). Analysis of the expression level of Smad4, TGF-βRII and p21 waf1 , as well as the clinical and pathological characteristics of esophageal SCC, revealed that the three proteins may be associated with the carcinogenesis, biological behavior and prognosis of esophageal SCC, parallel to the pathological stage and cell grade.

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Section: Discussionsupporting

confidence: 90%

Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue

et al. 2015

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“…While some investigators support the relationship of p53 with cancer prognosis [46,47], others reported that p53 overexpression is actually not p53-expression and the Outcome of Early Gastric Cancer related to the prognosis of neoplastic diseases, including gastric cancer [19,20]. In this study, the overexpression of p53 showed no significant relationship with the outcome of patients.…”

Section: Discussioncontrasting

confidence: 64%

Prognostic Significance of p53 Protein Expression in Early Gastric Cancer

Gonçalves

Carneiro

Martins

et al. 2010

Pathol. Oncol. Res.

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Mutations of the p53 tumor suppressor gene have been associated with abnormalities in cell cycle regulation, DNA repair and synthesis, apoptosis, and it has been implicated in the prognosis of advanced gastric cancer. The aim of this study was to evaluate the occurrence of p53 gene mutation and its possible prognostic implications in early gastric cancer. In a retrospective study, we studied 80 patients with early gastric cancer treated surgically between 1982 and 2001. Mutation of p53 gene was investigated in surgical gastric specimens by immunohistochemistry, and results were analyzed in relation to gender, age, macroscopic appearance, size and location of tumor, presence of lymph nodes, Lauren's histological type, degree of differentiation, and the 5-year survival. The expression of p53 was more frequent among the intestinal type (p = 0.003), the differentiated (p = 0.007), and the macroscopically elevated tumors (p = 0.038). Nevertheless, the isolated expression of p53 was not associated with the 5-year survival, or with the frequency of lymph node involvement. The degree of differentiation was detected as an independent factor related to the outcome of patients (0.044). Significantly shorter survival time was found in p53-negative compared with p53-positive patients, when considering the degree of differentiation of tumors, as assessed by Cox regression analysis (0.049). The association of p53 with the intestinal type, the degree of differentiation and morphological characteristics, may reflect the involvement of chronic inflammatory process underlying early gastric cancer. In this population sample, the expression of p53 alone has no prognostic value for early gastric cancer. However, the significant difference in p53 expression between subgroups of degree of differentiation of tumors can influence post-operative outcome of patients and may be related to possible distinct etiopathogenic subtypes.

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“…Based on these criteria, areas of focal staining with the highest percentage of p53- and p21-positive nuclear staining within deep tumor tissue were estimated. A tumor was scored as p21- or p53-positive when more than 10% of the tumor cells had nuclear staining, in keeping with previous reports [10]. HIF-1α expression was frequently evident in regions around the invading edges of the tumor, and necrotic areas such as those close to a deep ulcer.…”

Section: Methodssupporting

confidence: 58%

Relationship of hypoxia-inducible factor 1α and p21WAF1/CIP1 expression to cell apoptosis and clinical outcome in patients with gastric cancer

et al. 2006

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Growth pattern and expressions of cell cycle regulator proteins p53 and p21WAF1/CIP1 in early gastric carcinoma

Cited by 20 publications

References 80 publications

Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue

Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue

Prognostic Significance of p53 Protein Expression in Early Gastric Cancer

Relationship of hypoxia-inducible factor 1α and p21WAF1/CIP1 expression to cell apoptosis and clinical outcome in patients with gastric cancer

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