Growth parameters in children with dyspepsia symptoms and Helicobacter pylori infection

Abstract

Controversy exists about relationship of H. pylori infection and somatic growth retardation of children. The aim of this study was to evaluate the relationship between H. pylori infection and growth parameters in children. 113 children with dyspepsia (4-18 years) were enrolled. C13 urea breath test was performed for determination of H.pylori infection. Height, weight, body mass index (BMI) and standard deviation score (SDS) was calculated and growth parameters were compared between two groups of H.pylori positive and those with negative results. The prevalence of H.pylori infection was 52.2%. There was no meaningful relation between calculated SDS (for height and BMI) and H.pylori infection.

Effect of Helicobacter pylori infection on growth trajectories in young Ethiopian children: a longitudinal study

“…12 Another cross-sectional study among children from a low-income country reported a significantly higher number of H. pylori-infected children than non-infected children falling below the 5 th percentile of height-for-age. 31 In contrast with these findings, no association between height and H. pylori infection was reported in studies of children from Alaska, 32 Australia, 33 Iran, 34 and Guatemala. 35 These inconsistent findings could be due to variations in age, outcome ascertainment, and differences in the method used for the assessment of H. pylori status.…”

Helicobacter pylori Infection and Children's Growth

“…This association became nonsignificant after controlling for socioeconomic variables, and no differences were found between the groups in the average weight, body mass index (BMI), and BMI z score (40). Similarly, other studies found no differences between H pylori-infected and -uninfected children in average weight (38), BMI, weight-for-age z score (WAZ) (11), weight for age percentile (25,35) or WHZ (11)(12)(13)15,31,36). In the Czech Republic, children who had evidence of H pylori infection had a significantly lower mean BMI than did uninfected ones, independent of socioeconomic factors (23); however, a recent study from the same country showed null results with weight and BMI (24).…”

Review: Prevalence and dynamics of Helicobacter pylori infection during childhood

“…Six papers reported UBT/stool results on H. pylori infection in symptomatic children (symptoms include: gastrointestinal symptoms, dyspepsia/dyspeptic symptoms, chronic abdominal pain, recurrent abdominal pain, upper abdominal pain or suspicion of peptic diseases; code 4 from Figure ) (Figure [references: ]). The random‐effects regression model shows 42% H. pylori prevalence (95% CI: 25%‐59%).…”