In the pediatric population, the risk of developing an infectious endocarditis following the percutaneous closure of an atrial septal defect (ASD) is extremely rare. We report the case of a 10-year-old child who developed an infectious endocarditis nineteen months after closure with an Amplatzer septal occluder without residual shunt. The patient was treated with triple antibiotic regimen successfully, avoiding device removal. Trans-esophageal color Doppler suggested lack of endothelialization of the device, the most commonly described finding on extracted devices following an infective endocarditis. Proper assessment of the endothelialization process of septal occlusion devices is needed for individualized endocarditis prophylaxis.