This study emphasizes the innovative application of FePt
and Cu
core–shell nanostructures with increased lattice microstrain,
coupled with Au single-atom catalysis, in significantly enhancing •OH generation for catalytic tumor therapy. The combination
of core–shell with increased lattice microstrain and single-atom
structures introduces an unexpected boost in hydroxyl radical (•OH) production, representing a pivotal advancement
in strategies for enhancing reactive oxygen species. The creation
of a core–shell structure, FePt@Cu, showcases a synergistic
effect in •OH generation that surpasses the combined
effects of FePt and Cu individually. Incorporating atomic Au with
FePt@Cu/Au further enhances •OH production. Both
FePt@Cu and FePt@Cu/Au structures boost the O2 →
H2O2 → •OH reaction
pathway and catalyze Fenton-like reactions. This enhancement is underpinned
by DFT theoretical calculations revealing a reduced O2 adsorption
energy and energy barrier, facilitated by lattice mismatch and the
unique catalytic activity of single-atom Au. Notably, the FePt@Cu/Au
structure demonstrates remarkable efficacy in tumor suppression and
exhibits biodegradable properties, allowing for rapid excretion from
the body. This dual attribute underscores its potential as a highly
effective and safe cancer therapeutic agent.