Growth of influenza A viruses in hamsters

Abou-Donia, Hadia A.; Jennings, R.; Potter, C. W.

doi:10.1007/bf01317321

Cited by 14 publications

(9 citation statements)

References 27 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Abou Donia et al . later confirmed that temperature-sensitive influenza virus mutants showed reduced growth in the lungs, but not the nasal turbinates, of hamsters, similar to the phenotype of these viruses in man [183]. …”

Section: Animal Models Of Influenzamentioning

confidence: 73%

See 1 more Smart Citation

Animal Models for Influenza Virus Pathogenesis and Transmission

Bouvier

Lowen

2010

Viruses

322

361

View full text Add to dashboard Cite

Abstract:Influenza virus infection of humans results in a respiratory disease that ranges in severity from sub-clinical infection to primary viral pneumonia that can result in death. The clinical effects of infection vary with the exposure history, age and immune status of the host, and also the virulence of the influenza strain. In humans, the virus is transmitted through either aerosol or contact-based transfer of infectious respiratory secretions. As is evidenced by most zoonotic influenza virus infections, not all strains that can infect humans are able to transmit from person-to-person. Animal models of influenza are essential to research efforts aimed at understanding the viral and host factors that contribute to the disease and transmission outcomes of influenza virus infection in humans. These models furthermore allow the pre-clinical testing of antiviral drugs and vaccines aimed at reducing morbidity and mortality in the population through amelioration of the virulence or transmissibility of influenza viruses. Mice, ferrets, guinea pigs, cotton rats, hamsters and macaques have all been used to study influenza viruses and therapeutics targeting them. Each model presents unique advantages and disadvantages, which will be discussed herein.

show abstract

Section: Animal Models Of Influenzamentioning

confidence: 73%

“…Like ferrets, guinea pigs and cotton rats, hamsters are naturally susceptible to unadapted human influenza virus isolates, including influenza A subtypes H1N1 [179–181], H2N2 [179,180,182], and H3N2 [179–181,183–185], and influenza B viruses [180,186]. …”

Section: Animal Models Of Influenzamentioning

confidence: 99%

Animal Models for Influenza Virus Pathogenesis and Transmission

Bouvier

Lowen

2010

Viruses

322

361

View full text Add to dashboard Cite

show abstract

“…Several animal species can be experimentally infected with influenza viruses (Luke and Subbarao, 2008;van der Laan et al, 2008). Ferrets and mice (UNIT 15G.3) are the most commonly used models; however, hamsters (Abou-Donia et al, 1980;Heath et al, 1983;Subbarao et al, 1993), guinea pigs (Phair et al, 1979;Lowen et al, 2006), cotton rats (Sigmodon;Niewisk and Prince, 2002;Ottolini et al, 2005), and rats (Rattus; Teh et al, 1980) have also been used for influenza research. The protocols in this unit describe intranasal administration of influenza virus to lightly anesthetized ferrets, observation of clinical illness where relevant, collection of organs for virologic analysis, methods to quantify virus load in tissues, and processing of tissues for histopathologic examination.…”

Section: Introductionmentioning

confidence: 99%

The Ferret Model for Influenza

2009

View full text Add to dashboard Cite

A major challenge in influenza research is the selection of an appropriate animal model that accurately reflects the disease and protective immune response to influenza infection in humans. Ferrets are exquisitely susceptible to infection with human influenza viruses and are widely believed to be the ideal small animal model for influenza research. Mice have also been used for influenza vaccine research for decades. Ferrets are used as an animal model for the study of influenza because they are susceptible to human influenza viruses and develop some of the symptoms of influenza that are seen in humans. Although they are not discussed in detail in this unit, hamsters, guinea pigs, and both cotton rats (Sigmodon) and rats (Rattus) have also been used for influenza research. Curr. Protoc. Microbiol. 13:15G.2.1‐15G.2.29. © 2009 by John Wiley & Sons, Inc.

show abstract

“…Thus, only a lhnited number of virus strains have been studied to date, and the behaviour of further strains is indicated; indeed, among the strains tested, two exceptions to the above trends were found, and although dear differences in behaviour have been reported for the ts attenuated virus strains (ll), this is not as evident for attenuated strains produced by other techniques (1). Secondly, there is not agreement as to which of the tested viruses are attenuated and which virulent; the present classification is based on the reports and opinions of Dr. A. S. Beare, but these are not necessarily agreed by all the workers; furthermore, the present studies and human virulence studies have not been carried out with the same virus pools, and the behaviour of some viruses may change in passage.…”

Section: Discussionmentioning

confidence: 94%

Transmissibility of influenza viruses in hamsters

Ali

Teh

Jennings

et al. 1982

Archives of Virology

Self Cite

View full text Add to dashboard Cite

The growth characteristics of a series of influenza A viruses in the turbinates and lungs of hamsters was measured: in addition, the susceptibility of hamsters to infection by these viruses was also determined. These two criteria were used to give estimates of the growth potential of influenza viruses in hamsters, and the results were related to the incidence of transmission of virus from inoculated hamsters to cage-contacts. The results showed that strains of influenza virus reported as virulent for man tended to grow to higher titres in hamster nasal washings and lungs; were more infective for hamsters when inoculated by the intranasal route; and showed a high incidence of spread to cage-contacts. The methods could provide valuable measurements of virus attenuation and transmissibility for man, and the further exploitation of these techniques could facilitate the production and licensing of live, attenuated influenza virus vaccines.

show abstract

Growth of influenza A viruses in hamsters

Cited by 14 publications

References 27 publications

Animal Models for Influenza Virus Pathogenesis and Transmission

Animal Models for Influenza Virus Pathogenesis and Transmission

The Ferret Model for Influenza

Transmissibility of influenza viruses in hamsters

Contact Info

Product

Resources

About