Growth of Children with Food Allergy

Pavić, Ivan; Kolaček, Sanja

doi:10.1159/000462973

Cited by 12 publications

(12 citation statements)

References 41 publications

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“…Outside of inflammation, comorbidities as well as medication management (i.e. steroid use) also appear to play a role in height growth in food allergic children . What our survey adds is that these factors affect height growth, irrespective of the location and type of allergy centre at which a child is seen.…”

Section: Discussionmentioning

confidence: 79%

International survey on growth indices and impacting factors in children with food allergies

Meyer

Wright

Vieira

et al. 2018

J Human Nutrition Diet

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Background: Elimination diets required for the management of food allergies increase the risk for poor growth in children. Currently, no worldwide data exist on this topic and limited published data exist on the impact of atopic comorbidity, type of allergy and foods eliminated on growth. We therefore set out to perform a worldwide survey on growth and impacting factors in food allergic children. Methods: A prospective growth survey was performed of children (aged 0-16 years) on an elimination diet with confirmed immunoglobulin (Ig)E and non-IgE mediated food allergies. Data collected included: weight-for-age, weight-for-height, height-for-age, head circumference, body mass index, type of food allergy and eliminated foods, allergic comorbidities and replacement milk/breast milk. Multivariable regression analysis was used to establish factors that affected growth. Results: Data from 430 patients from twelve allergy centres were analysed: median age at diagnosis and data collection was 8 months and 23 months, respectively. Pooled data indicated that 6% were underweight, 9% were stunted, 5% were undernourished and 8% were overweight. Cow's milk elimination lead to a lower weight-for-height Z-scores than other food eliminations and mixed IgE and non-IgE mediated allergy had lower height-forage Z-scores than IgE mediated allergy. Children with only non-IgE mediated allergies had lower weight-for-height and body mass index. Atopic comorbidities did not impact on growth. Conclusions: Stunting is more common in children with food allergies than low weight. Children particularly at risk of poor growth are those with non-175

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Section: Discussionmentioning

confidence: 79%

International survey on growth indices and impacting factors in children with food allergies

Meyer

Wright

Vieira

et al. 2018

J Human Nutrition Diet

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“…It is accepted that FA can affect childhood and adolescent growth, with stunting being the most common effect. 26 This condition is described during elimination diets, but also at the time of diagnosis, irrespective of whether they are under a dietician's control or if their nutritional requirements were fulfilled. 26 Asthmatic persons' growth is always a concern in this population, especially due to its treatment, corticosteroids.…”

Section: Discussionmentioning

confidence: 99%

Food allergy as an asthma comorbidity in children and adolescents: a practical approach through a real-world study

Esteban-Gorgojo¹,

Gorgojo²,

Sastre

et al. 2021

aei

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Introduction: Several studies have shown interactions between food allergy (FA) and asthma, but the influence of FA in asthma traits has been scarcely studied. Methods: A real-world retrospective observational study was conducted among patients between 3 and 18 years old referred to our Asthma Clinic from November 2014 to November 2017. Data were obtained from daily clinical practice. Only patients properly diagnosed with asthma and FA were included. Results: 815 patients were included: 483 asthmatics and 332 non-asthmatics and 180 FA and 635 no FA. Food allergy was statistically more prevalent among asthma patients (p = 0.014). In a high pollen exposure area, Madrid, among subjects with asthma (121 FA, 362 no-FA), sensitization to lipid transfer protein (LTP) (p = 0.016, OR: 3.064, RR: 2.512) and pollen (p = 0.016, OR: 3.064, RR: 2.512) are risk factors to have a concomitant FA diagnosis, whereas sensitization to profilin is not. Peripheral blood eosinophils were higher in subjects with asthma and FA (≥450 eos/µL) than in asthmatics without FA (≤300 eos/µL) (p = 0.031). Blood eosinophilia, using a cut-off >300 eos/µL, was only present in the FA group. Therefore, this trait should be considered when phenotyping a patient as eosinophilic asthma. Sex had an impact on several variables: height, weight, BMI, blood eosinophils count, sensitization profile, and early-onset asthma. Conclusions: Asthma and FA are closely related and the presence of FA should be investigated in every asthma patient. This study shows an association between asthma with concomitant FA and sensitization to pollen and LTP, blood eosinophilia, and growth alterations. Differences between boys and girls were also described, so a sex-specific approach is recommended.

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“…An increasing amount of data on the growth of children with food allergies, particularly CMA, is accumulating[26,27]. Children with food allergies might indeed be at risk of growth failure for several reasons, such as the mismanagement of an elimination diet or a delay in CMA diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Hypoallergenicity of a thickened hydrolyzed formula in children with cow’s milk allergy

Rossetti

Cucchiara

et al. 2019

WJCC

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BACKGROUND Allergy to cow’s milk is the most frequent allergy occurring in infants and young children. The dietary management of these patients consists of the elimination of any cow’s milk proteins from the diet, and for formula-fed infants, the substitution of the usual infant formula with an adapted formula that is generally based on extensively hydrolyzed cow’s milk proteins. The American Academy of Pediatrics has established specific criteria to confirm the hypoallergenicity of a formula intended for these children. AIM To assess the hypoallergenicity of a new thickened extensively hydrolyzed casein-based formula (TeHCF) in children with cow’s milk allergy (CMA). METHODS Children diagnosed with CMA through a double-blind placebo-controlled food challenge (DBPCFC) were randomly administered increased doses of a placebo formula or the TeHCF [Allernova, new thickener including fibres (Novalac)] under double-blind conditions and medical surveillance on two separate days. Otherwise, both of these formulas and a cow’s milk-based formula were randomly introduced to children who were highly suspected of having CMA on three separate days. Immediate and late reactions occurring after the introduction of any of these formulas were thoroughly recorded by the physician at the hospital and reported by parents to the physician after hospital discharge, respectively. If the children tolerated the TeHCF during the DBPCFC, they were exclusively fed this formula during a 3-mo period where potential allergic symptoms, anthropometric parameters, as secondary outcomes, and adverse events were registered. The Cow’s Milk-related Symptoms Score (CoMiSS TM ) was assessed and anthropometric parameters were compared to World Health Organization (WHO) reference data. RESULTS Of the 30 children included in the study, the CMA diagnosis of 29 (mean age: 8.03 ± 7.43 mo) patients was confirmed by a DBPCFC. The children all tolerated the TeHCF during both the challenge and the subsequent 3-mo feeding period, which they all completed. During the latter period, the CoMiSS TM remained at a very low level, never exceeding its baseline value (1.4 ± 2.0), growth parameters were within WHO reference standards and no adverse event related to the TeHCF was reported. Over the first week of this period, the proportion of patients with digestive discomfort significantly decreased from 20.7% (6/29) to 3.4% (1/29), P = 0.025. The proportion of satisfaction with the overall effect of the formula reported by the parents and investigator was high, as was the formula acceptability by the child. CONCLUSION The new TeHCF meets the hypoallergenicity criteria according to the American Academy of Pediatrics standards, confirming that the tested TeHCF is adapted to the dietary management of children with CMA. Moreover, growth was adequate in the included p...

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Growth of Children with Food Allergy

Cited by 12 publications

References 41 publications

International survey on growth indices and impacting factors in children with food allergies

International survey on growth indices and impacting factors in children with food allergies

Food allergy as an asthma comorbidity in children and adolescents: a practical approach through a real-world study

Hypoallergenicity of a thickened hydrolyzed formula in children with cow’s milk allergy

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