Growth of children on the ketogenic diet

Vining, Eileen P.G.; Pyzik, Paula L.; McGrogan, Jane R.; Hladky, Heather D.; Anand, Akash; Kriegler, Steven; Freeman, John M.

doi:10.1111/j.1469-8749.2002.tb00769.x

Cited by 161 publications

(30 citation statements)

References 16 publications

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“…Most side‐effects can be alleviated by adjustment to the diet. There is also evidence of impaired growth in children on the KD, with younger children being more at risk (Vining et al. , 2002; Liu et al.…”

Section: Practical Considerationsmentioning

confidence: 99%

Efficacy of dietary treatments for epilepsy

Neal¹,

Cross²

2010

J Human Nutrition Diet

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The ketogenic diet (KD) is a high fat, restricted carbohydrate regime that has been used as a treatment for seizures since the 1920s, when it was designed to induce a similar metabolic response to fasting. A modification of this early classical version of the KD was introduced in the 1970s using medium chain triglycerides as an alternative fat source. More recently, two alternative, less-restrictive dietary treatments have been developed: the modified Atkins diet and the low glycaemic index diet. There are many case reports and observational studies reporting successful use of the KD, and a growing number of studies reporting similar success with the modified Atkins protocol. A recent randomised controlled trial has shown a significant benefit of the KD compared to no change in treatment. The use of these dietary therapies in the UK is supported by literature evidence, although often is limited by a lack of resources; increasing awareness and knowledge is fundamental to ensure availability for those individuals with intractable epilepsy who may benefit from them.

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Section: Practical Considerationsmentioning

confidence: 99%

Efficacy of dietary treatments for epilepsy

Neal¹,

Cross²

2010

J Human Nutrition Diet

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“…Serum vitamin D concentrations improve while on the KD, as a result of supplementation (4). Despite bone-sparing effects of improved vitamin D status, some data indicate that use of the KD treatment may lead to growth failure, alteration in body composition, and osteopenia in some patients (5)(6)(7)(8). The purpose of this pilot study was to evaluate the pattern of change in bone health in children with IE during 15 mo of exposure to the KD compared with healthy children.…”

Section: Introductionmentioning

confidence: 97%

Progressive bone mineral content loss in children with intractable epilepsy treated with the ketogenic diet

Bergqvist

Schall

Stallings

et al. 2008

The American Journal of Clinical Nutrition

163

119

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“…What is less known is that LC‐HFDs are also useful for the treatment of intractable epilepsy in children (15,16,17,18). One concern regarding the use of such diets for the treatment of epilepsy is that the diet has been demonstrated to affect the normal longitudinal growth especially in younger children (19,20,21). One contributing factor to the lack of normal growth may be the effect of the diet on body composition and possibly insufficient lean body mass (LBM) accretion.…”

Section: Introductionmentioning

confidence: 99%

Low‐carbohydrate High‐fat Diets: Regulation of Energy Balance and Body Weight Regain in Rats

Caton¹,

Bai²,

Burget³

et al. 2009

Obesity

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The aim of the current investigations was to examine the effects of a low‐carbohydrate high‐fat diet (LC‐HFD) on body weight, body composition, growth hormone (GH), IGF‐I, and body weight regain after stopping the dietary intervention and returning the diet back to standard laboratory chow (CH). In study one, both adolescent and mature male Wistar rats were maintained on either an isocaloric LC‐HFD or CH for 16 days before having their diet switched. In study two, mature rats were maintained on either LC‐HFD or CH for 16 days to determine the effects of the LC‐HFD on fat pad weight. LC‐HFD leads to body weight loss in mature rats (P < 0.01) and lack of body weight gain in adolescent rats (P < 0.01). Despite less body weight, increased body fat was observed in rats maintained on LC‐HFD (P < 0.05). Leptin concentrations were higher (P < 0.05), and IGF‐I (P < 0.01) concentrations were reduced in the LC‐HFD rats. When the diet was returned to CH following LC‐HFD, body weight regain was above and beyond that which was lost (P < 0.01). The LC‐HFD resulted in increased body fat and had a negative effect upon both GH and IGF‐I concentrations, which might have implications for the accretion and maintenance of lean body mass (LBM), normal growth rate and overall metabolic health. Moreover, when the LC‐HFD ceases and a high‐carbohydrate diet follows, more body weight is regained as compared to when the LC‐HFD is consumed, in the absence of increased energy intake.

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Growth of children on the ketogenic diet

Cited by 161 publications

References 16 publications

Efficacy of dietary treatments for epilepsy

Efficacy of dietary treatments for epilepsy

Progressive bone mineral content loss in children with intractable epilepsy treated with the ketogenic diet

Low‐carbohydrate High‐fat Diets: Regulation of Energy Balance and Body Weight Regain in Rats

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