Growth of calcium oxalate monohydrate on uric acid crystals at sustained supersaturation

Bouropoulos, C.; Vagenas, N; Klepetsanis, Pavlos; Stavropoulos, Nikolaos; Bouropoulos, Nikolaos

doi:10.1002/crat.200310241

Cited by 18 publications

(13 citation statements)

References 12 publications

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“…A scanning electron micrograph (Panel A) shows large uric acid crystals (arrowhead), which served as seeds for the formation of calcium oxalate crystals (arrows). Reprinted from Bouropoulos et al 21 with the permission of the publisher. In Panel B, a scanning electron micrograph shows numerous small calcium oxalate crystals (arrows) formed on larger uric acid crystals (arrowheads).…”

Section: Figurementioning

confidence: 99%

The Tumor Lysis Syndrome

2011

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Section: Figurementioning

confidence: 99%

The Tumor Lysis Syndrome

2011

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“…32,33 The presence of UA crystals could induce the development of COM through heterogeneous nucleation. [33][34][35] UA could function as a nidus to induce the generation, precipitation, and aggregation of CaOx crystals. 36 Moreover, UA crystals, which are better nucleating agents than mucoproteins (glycoprotein) and cell debris, can induce the development of COM as a heterogeneous nucleating agent.…”

Section: Eds Analysis Of Urinary Crystallitesmentioning

confidence: 99%

Nanouric acid or nanocalcium phosphate as central nidus to induce calcium oxalate stone formation: a high-resolution transmission electron microscopy study on urinary nanocrystallites

Gao¹,

Xue²,

Xu³

et al. 2014

IJN

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Purpose This study aimed to accurately analyze the relationship between calcium oxalate (CaOx) stone formation and the components of urinary nanocrystallites. Method High-resolution transmission electron microscopy (HRTEM), selected area electron diffraction, fast Fourier transformation of HRTEM, and energy dispersive X-ray spectroscopy were performed to analyze the components of these nanocrystallites. Results The main components of CaOx stones are calcium oxalate monohydrate and a small amount of dehydrate, while those of urinary nanocrystallites are calcium oxalate monohydrate, uric acid, and calcium phosphate. The mechanism of formation of CaOx stones was discussed based on the components of urinary nanocrystallites. Conclusion The formation of CaOx stones is closely related both to the properties of urinary nanocrystallites and to the urinary components. The combination of HRTEM, fast Fourier transformation, selected area electron diffraction, and energy dispersive X-ray spectroscopy could be accurately performed to analyze the components of single urinary nanocrystallites. This result provides evidence for nanouric acid and/or nanocalcium phosphate crystallites as the central nidus to induce CaOx stone formation.

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“…Numerous studies concerning the mechanisms of the formation of both COM and of the dihydrate salt (CaC 2 O 4 ·2H 2 O, COD or wheddellite) have been reported (Nicar et al, 1987;Streit et al, 1998;Millan et al, 1997). COM crystallization studies included seeded crystal growth at different fluid dynamic conditions (Grases et al, 1989;Millan, 1997 et al, 1998) and the spontaneous precipitation of COM in highly supersaturated solutions (Bouropoulos et al, 2004;Guo et al, 2002). Additional evidence for the consolidation effect of calcium oxalate deposits is provided by findings that these salts do not have adverse effect on cement hydration.…”

Section: Introductionmentioning

confidence: 98%