Growth of a long bone cross section – A 2D phase-field model

Lindberg, Gustav; Ståhle, Per

doi:10.1016/j.mbs.2019.04.005

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…In conclusion the preliminary result is that the part of the cross-section having the largest stress gradient has absorbed the highest amount of iodine. Hence the study strengthens the hypotheses about stress-driven diffusion in bone tissue suggested in [4,5].…”

Section: Discussionsupporting

confidence: 87%

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On Stress Driven Diffusion in Bone -- An Experimental Study

Lindberg,

Ståhle

2021

Preprint

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The transport of nutrients or signal constituents that stimulate growth of bone tissue is supposed to be affected by a static mechanical load. It follows from basic thermodynamical principles that constituents causing volumetric change are dragged along the gradients of hydrostatic stress. The present preliminary study examines the behaviour of iodine present in the medullary cavity of a bovine long bone exposed to mechanical load. A section of the bone is xray scanned with the static load present, with and without the iodine. The resulting distribution in a selected 2D plane is numerically evaluated using a discrete Radon's inverse transform. The result suggests that iodine is a useful constituent with a good attenuation effect on the x-ray beam and clearly reveals the temporal distribution of its transport through the bone. It further result shows some indication that stress does affect the iodine distribution. .

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Section: Discussionsupporting

confidence: 87%

“…The hollow cross-sections of long bones offer a density effective mean for supporting a large variety of loading modes. It has been shown that long bones grow in places where the stress is large to form a cross-section that increases its load carrying capacity and by decreasing the largest cross-sectional stress [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

On Stress Driven Diffusion in Bone -- An Experimental Study

Lindberg,

Ståhle

2021

Preprint

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Phase-field modelling of fracture in viscoelastic composite using isogeometric FCM

Zhen,

Hu,

Liu

et al. 2024

International Journal of Mechanical Sciences

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Altered bone development with impaired cartilage formation precedes neuromuscular symptoms in spinal muscular atrophy

Hensel

Brickwedde

Tsaknakis³

et al. 2020

Human Molecular Genetics

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Abstract Spinal Muscular Atrophy (SMA) is a fatal neurodegenerative disease of newborns and children caused by mutations or deletions of the Survival of motoneuron gene 1 (SMN1) resulting in low levels of the SMN protein. While neuromuscular degeneration is the cardinal symptom of the disease, the reduction of the ubiquitously expressed SMN additionally elicits non-motoneuron symptoms. Impaired bone development is a key feature of SMA but it is yet unknown whether this is an indirect functional consequence of muscle weakness or caused by bone-intrinsic mechanisms. Therefore, we radiologically examined SMA patients in a prospective, non-randomized cohort study characterizing bone size and bone mineral density (BMD) and performed equivalent measurements in pre-symptomatic SMA mice. BMD as well as lumbar vertebral body size were significantly reduced in SMA patients. This growth defect but not BMD reduction was confirmed in SMA mice by μCT before the onset of neuromuscular symptoms indicating that it is at least partially independent of neuromuscular degeneration. Interestingly, the number of chondroblasts in the hypertrophic zone of the growth plate was significantly reduced. This was underlined by RNAseq and expression data from developing SMA mice vertebral bodies which revealed molecular changes related to cell division and cartilage remodeling. Together, these findings suggest a bone intrinsic defect in SMA. This phenotype may not be rescued by novel drugs which enhance SMN levels in the central nervous system only.

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Growth of a long bone cross section – A 2D phase-field model

Cited by 3 publications

References 38 publications

On Stress Driven Diffusion in Bone -- An Experimental Study

On Stress Driven Diffusion in Bone -- An Experimental Study

Phase-field modelling of fracture in viscoelastic composite using isogeometric FCM

Altered bone development with impaired cartilage formation precedes neuromuscular symptoms in spinal muscular atrophy

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