Growth kinetics, phenolic compounds profile and pigments analysis of Galdieria sulphuraria cultivated in whey permeate in shake-flasks and stirred-tank bioreactor

Zimermann, Jéssika Darc Fernandes; Sydney, Eduardo Bittencourt; Cerri, Maria Luísa; Carvalho, Isabella; Schafranski, Kathlyn; Sydney, Alessandra Cristine Novak; Vitali, Luciano; Gonçalves, Samantha; Micke, Gustavo Amadeu; Soccol, Carlos Ricardo; Demiate, Ivo Mottin

doi:10.1016/j.jwpe.2020.101598

Cited by 20 publications

(15 citation statements)

References 57 publications

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“…The ethanol extracts of selected strains were analysed by HPLC, in order to collect more information about the specific pigments (carotenoids and chlorophylls). The main peaks of each species were identified (Moore et al 1995;Graziani et al 2013;Goecke et al 2020;Zimermann et al 2020). The overall picture showed a high variability of xanthophylls, both identified and not identified, among samples.…”

Section: Discussionmentioning

confidence: 94%

Thermo resistant antioxidants from photoautotrophic microorganisms: screening and characterization

D’Elia

Imbimbo

Liberti

et al. 2021

World J Microbiol Biotechnol

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The demand for natural antioxidants to be used in food industry is increasing, as synthetic antioxidants are toxic and have high production costs. Specifically, food processing and preservation require antioxidants resistant to thermal sterilization processes. In this study, twenty-five strains among microalgae and cyanobacteria were screened as antioxidants producers. The species Enallax sp., Synechococcus bigranulatus and Galdieria sulphuraria showed the highest content of chlorophyll a and total carotenoids. In vitro stability and antioxidant activity of the ethanolic extracts were performed. The results revealed that pigments present in the extracts, obtained from the previously mentioned species, were stable at room temperature and exhibited in vitro free radical scavenging potential with IC 50 values of 0.099 ± 0.001, 0.048 ± 0.001 and 0.13 ± 0.02 mg mL -1 , respectively. Biocompatibility assay showed that the extracts were not toxic on immortalized cell lines. The antioxidant activity was also tested on a cell-based model by measuring intracellular ROS levels after sodium arsenite treatment. Noteworthy, extracts were able to exert the same protective effect, before and after the pasteurization process. Results clearly indicate the feasibility of obtaining biologically active and thermostable antioxidants from microalgae. Green solvents can be used to obtain thermo-resistant antioxidants from cyanobacteria and microalgae which can be used in the food industry. Thus, the substitution of synthetic pigments with natural ones is now practicable.

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Section: Discussionmentioning

confidence: 94%

Thermo resistant antioxidants from photoautotrophic microorganisms: screening and characterization

D’Elia

Imbimbo

Liberti

et al. 2021

World J Microbiol Biotechnol

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“…Among physicochemical processes, there is coagulation [4], electrocoagulation [5], forward osmosis [6], chemical precipitation [7], adsorption [8], and oxidation [9]. As for biological systems, there are many technologies such as sequencing batch reactor [10], bioaugmentation [11], biosorption [12], membrane bioreactor [13], anaerobic digestion [14]… etc. In fact, each process has its advantages and disadvantages; hence the process performance is highly dependent on the nature of the effluent and the flow to be treated.…”

Section: Sewage -Recent Advances New Perspectives and Applicationsmentioning

confidence: 99%

“…Heavy metals could also be removed by this biological system. The reference [11] has shown that this system is capable to remove chromium from a tannery effluent with a removal rate of 96.1% using a low volumetric organic load. As well, [37] has indicated that several heavy metals (Nickel, chromium, cadmium, cobalt, zinc, and silver) were eliminated from brassware effluent through this system with high removal rates that reached more than 60%.…”

Section: Sewage -Recent Advances New Perspectives and Applicationsmentioning

confidence: 99%

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Biological versus Physicochemical Technologies for Industrial Sewage Treatment: Which Is the Most Efficient and Inexpensive?

Elkarrach¹,

Atia²,

Omor³

et al. 2022

Sewage - Recent Advances, New Perspectives and Applications

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Industries play a major role in the development of countries′ economy. However, they are known as the biggest source of water pollution in the whole world. In fact, several industries use a huge amount of water in their manufacturing operations, and then, they reject a large volume of wastewaters such as tanneries, brassware, olive mills … etc. The sewage of these industries may contain organic/inorganic matters or toxic components that harm human health and the environment. Therefore, the treatment of these effluents is necessary. For that, there are many treatment processes, including biological and physicochemical processes or both. The choice of adequate process is depending on many reasons, especially on the biodegradability degree of each effluent, as well as the presence of recalcitrant pollutants. Nevertheless, biological technologies, particularly bioremediation, are recently an emerging technology for the elimination of recalcitrant pollutants like heavy metals. Furthermore, these biotechnologies are simple, efficient, eco-friendly and inexpensive. Therefore, this environmental biotechnology may be a new approach for the treatment of industrial sewage, so, it can successfully replace physicochemical technologies that are very expensive.

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“…Kepekçi and Saygideger [60] enhanced the production of phenolic compounds (49.83 ± 5.56 mg GAE/g DW) using a two‐step batch mode cultivation with S. platensis . Furthermore, G. sulphuraria grown in whey permeate in stirred tank bioreactor showed enhanced production of ellagic acid (860 µg/g, two times greater than the content in raspberries) [80]. C. sorokiniana grown in cane vinasse (0.1%) medium supplemented with N:P:K (20–5–20 g/L) showed high content of phenolic compounds (15.28 ± 0.32 mg GAE/g, as compared to 6.02 ± 0.13 mg GAE/g in commercial medium) and flavonoids (72.30 ± 5.28 mg QE/g, as compared to 13.12 ± 1.33 mg QE/g in commercial medium) [91].…”

Section: Production Processes Of Mbpcsmentioning

confidence: 99%

Extraction and characterization of microalgae‐derived phenolics for pharmaceutical applications: A systematic review

et al. 2021

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Microalgae are regarded as a rich trove of diverse secondary metabolites that exert remarkable biological activities. In particular, microalgae‐derived bioactive phenolic compounds (MBPCs) are a boon to biopharmaceutical and nutraceutical industries due to their diverse bioactivities, including antimicrobial, anticancer, antiviral, and immunomodulatory activities. The state‐of‐the‐art green technologies for extraction and purification of MBPCs, along with the modern progress in the identification and characterization of MBPCs, have accelerated the discovery of novel active pharmaceutical compounds. However, several factors regulate the production of these bioactive phenolic compounds in microalgae. Furthermore, some microalgae species produce toxic phenolic compounds that negatively impact the aquatic ecosystem, animal, and human life. Therefore, the focus of this review paper is to bring into light the current innovations in bioprospection, extraction, purification, and characterization of MBPCs. This review is also aimed at a better understanding of the physicochemical factors regulating the production of MBPCs at an industrial scale. Finally, the present review covers the recent advances in toxicological evaluation, diverse applications, and future prospects of MBPCs in biopharmaceutical industries.

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Growth kinetics, phenolic compounds profile and pigments analysis of Galdieria sulphuraria cultivated in whey permeate in shake-flasks and stirred-tank bioreactor

Cited by 20 publications

References 57 publications

Thermo resistant antioxidants from photoautotrophic microorganisms: screening and characterization

Thermo resistant antioxidants from photoautotrophic microorganisms: screening and characterization

Biological versus Physicochemical Technologies for Industrial Sewage Treatment: Which Is the Most Efficient and Inexpensive?

Extraction and characterization of microalgae‐derived phenolics for pharmaceutical applications: A systematic review

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