Growth-Inhibitory Effect of Chemotherapeutic Drugs Dispensed by Inkjet Bioprinting on Cancer and Non-Cancer Cells

Rodríguez-Dévora, Jorge I.; Bhuyan, Mohammod; Reyna-Soriano, Daniel; Boland, Thomas

doi:10.2352/j.imagingsci.technol.2016.60.4.040406

Cited by 2 publications

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“…The size reduction approach to a faster dissolution of micron- and nanometer-sized API particles is now a significant area of research for several pharmaceutical and drug delivery companies. In recent times, several improved methodologies in printing techniques have been developed and tested for a variety of applications in the field of biology, medicine, materials, etc. − …”

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confidence: 99%

Evaluation of Cocrystallization Outcomes of Multicomponent Adducts: Rapid Fabrication to Achieve Uniform Particle Size Distribution Using Thermal Inkjet Printing

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Crystal Growth & Design

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Multicomponent adducts such as cocrystals and eutectics have become an integral part of the pharmaceutical industry since the application potential of such products is imminent in drug design and fabrication. Cocrystallization of metronidazole, an antibiotic antiprotozoal drug, belonging to the family of nitro-imidazole, with benzoic acid and mono-, di-, tri-, hydroxybenzoic acids results in multicomponent adducts with better physicochemical properties than the drug. Cocrystallization experiments using liquid assisted grinding (LAG), melt cool, and routine solvent evaporation yielded eutectics except for the combinations 3,5-dihydroxy and 3,4,5-trihydroxybenzoic acids, which produce cocrystals. The products have been characterized and analyzed using powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). In particular, the structures of the cocrystals were determined using single crystal X-ray diffraction, whereas those of the eutectics were identified based on PXRD, DSC, and binary phase diagram construction. Using well-known thermal inkjet printing (TIJP), organic solutions of metronidazole and substituted hydroxybenzoic acids were injected into a cartridge and printed onto the template via a jet dispensing mechanism by varying the drug–coformer stoichiometric ratio to generate the cocrystals and eutectics of the adducts in quick time. The products formed from inkjet printing show excellent consistency in the particle size distribution and can be easily subjected to scaling up in industry compared to those prepared using the conventional cocrystallization techniques such as slurry grinding, rotavapor, and routine solution evaporation, which are time-consuming and produce varying particle sizes, which is a hindrance to product development and scaling during mass production.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Cocrystallization Outcomes of Multicomponent Adducts: Rapid Fabrication to Achieve Uniform Particle Size Distribution Using Thermal Inkjet Printing

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2020

Crystal Growth & Design

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Physicochemical parameters that underlie inkjet printing for medical applications

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One of the most common types of 3D printing technologies is inkjet printing due to its numerous advantages, including low cost, programmability, high resolution, throughput, and speed. Inkjet printers are also capable of fabricating artificial tissues with physiological characteristics similar to those of living tissues. These artificial tissues are used for disease modeling, drug discovery, drug screening, and replacements for diseased or damaged tissues. This paper reviews recent advancements in one of the most common 3D printing technologies, inkjet dispensing. We briefly consider common printing techniques, including fused deposition modeling (FDM), stereolithography (STL), and inkjet printing. We briefly discuss various steps in inkjet printing, including droplet generation, droplet ejection, interaction of droplets on substrates, drying, and solidification. We also discuss various parameters that affect the printing process, including ink properties (e.g., viscosity and surface tension), physical parameters (e.g., internal diameter of printheads), and actuation mechanisms (e.g., piezoelectric actuation and thermal actuation). Through better understanding of common 3D printing technologies and the parameters that influence the printing processes, new types of artificial tissues, disease models, and structures for drug discovery and drug screening may be prepared. This review considers future directions in inkjet printing research that are focused on enhancing the resolution, printability, and uniformity of printed structures.

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Growth-Inhibitory Effect of Chemotherapeutic Drugs Dispensed by Inkjet Bioprinting on Cancer and Non-Cancer Cells

Cited by 2 publications

References 0 publications

Evaluation of Cocrystallization Outcomes of Multicomponent Adducts: Rapid Fabrication to Achieve Uniform Particle Size Distribution Using Thermal Inkjet Printing

Evaluation of Cocrystallization Outcomes of Multicomponent Adducts: Rapid Fabrication to Achieve Uniform Particle Size Distribution Using Thermal Inkjet Printing

Physicochemical parameters that underlie inkjet printing for medical applications

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