Growth‐inhibition Tests With Mycoplasma Mycoides as a Basis for Chemotherapy and Selective Culture Media

Turner, A. W.

doi:10.1111/j.1751-0813.1960.tb08594.x

Cited by 6 publications

(2 citation statements)

References 25 publications

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“…The MIC values for streptomycin and tylosin (10 and 0 04 ,tg ml-' respectively) were similar to those previously reported for M. mycoides strain V5 (8 and 0-07 g ml-1; Turner, 1960;Hudson & Etheridge, 1965), though the value for tetracycline was D. H. LEE, R. J. MILES AND J. R. M. INAL fourfold lower (Mr G. S. Cottew, footnote to the paper of Turner, 1960). The resistance of M. mycoides to rifampicin (400 #g ml-) is in agreement with reports for other mycoplasmas (Das & Maniloff, 1976).…”

Section: Discussionsupporting

confidence: 75%

Antibiotic sensitivity and mutation rates to antibiotic resistance inMycoplasma mycoidesssp.mycoides

Lee

Milès

Inal³

1987

Epidemiol. Infect.

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SUMMARYThe antibiotic resistance ofMycoplasma mycoidesssp.mycoidesstrain T1was investigated. This strain was resistant to high levels ( > 100 μg ml−1) of rifampicin and nalidixic acid. It was sensitive to streptomycin, spectinomycin and novobiocin; however, single step mutants with high levels of resistance ( > 100 μg ml−1) were readily isolated. With erythromycin and tylosin for which the minimum inhibitory concentration (MIC) for the parent strain was < 0·1 μg ml−1, mutants resistant to > 100 μg ml−1were obtained in two and three steps respectively. The MIC of tetracycline in single step resistant mutants (0·6 μg ml−1) was tenfold higher than the parent strain, but could not be increased further. There was only a twofold increase in resistance to chloramphenicol in single step mutants. The frequency of resistant mutants varied with the antibiotic and was between 4× 10minuss;6and 2× 10−8. The mutation rate to antibiotic resistance to streptomycin, spectinomycin, novobiocin, erythromycin and tylosin was between 3× 10−8and 5× 10−9per cell per generation. There was a fivefold decrease in mutation rate to resistance to 60 μg ml−1streptomycin compared to that to 20 μg ml−1.

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Section: Discussionsupporting

confidence: 75%

Antibiotic sensitivity and mutation rates to antibiotic resistance inMycoplasma mycoidesssp.mycoides

Lee

Milès

Inal³

1987

Epidemiol. Infect.

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“…were obtained. Turner (1960) found that the V 5 strain of M. mycoides var. mycoides was inhibited by 125 ,ug./ml.…”

Section: Discussionmentioning

confidence: 99%

Anin vitrocomparison of the effect of some antibacterial, antifungal and antiprotozoal agents on various strains ofMycoplasma(pleuropneumonia–like organisms: P.P.L.O.)

Newnham

Chu

1965

J. Hyg.

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A study was made in liquid medium over 7 days at 37° C. of the inhibitory action of nineteen antibacterial, antifungal and antiprotozoal drugs on twenty strains ofM. gallisepticum, eight other avian mycoplasmata, six mammalian mycoplasmata, two saprophytic mycoplasmata and the L-form ofStreptobacillus moniliformis(L–1).The twenty strains ofM. gallisepticumfrom Britain and other countries showed a similar range of drug sensitivity except where resistant strains were included. Tylosin and demethylchlortetracycline appeared to have the highest inhibitory action, followed by erythromycin, spiramycin, tetracycline, chlortetracycline, oxytetracycline and ethidium bromide. A ‘Zone Phenomenon’ frequently occurred with sodium aurothiomalate, inhibition often being observed between 0·1 and 2·0 μg./ml. Polymixin and nystatin had no inhibitory effect on the growth of any mycoplasmata tested. With the exception of erythromycin and streptomycin in some cases, the pattern of sensitivity observed with the mycoplasmata of diverse origin was similar to that ofM. gallisepticum, most strains, however, being somewhat more resistant thanM. gallisepticumto many of the drugs.

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Interaction of Mycoplasmas with Their Environment

Smith

1971

The Biology of Mycoplasmas

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Growth‐inhibition Tests With Mycoplasma Mycoides as a Basis for Chemotherapy and Selective Culture Media

Cited by 6 publications

References 25 publications

Antibiotic sensitivity and mutation rates to antibiotic resistance inMycoplasma mycoidesssp.mycoides

Antibiotic sensitivity and mutation rates to antibiotic resistance inMycoplasma mycoidesssp.mycoides

Anin vitrocomparison of the effect of some antibacterial, antifungal and antiprotozoal agents on various strains ofMycoplasma(pleuropneumonia–like organisms: P.P.L.O.)

Interaction of Mycoplasmas with Their Environment

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