Growth inhibition of head and neck carcinomas by <scp>D</scp>‐allose

Mitani, Tomoo; Hoshikawa, Hiroshi; Mori, Terushige; Hosokawa, Tomoyoshi; Tsukamoto, Ikuko; Yamaguchi, Fuminori; Kamitori, Kazuyo; Tokuda, Masaaki; Mori, Nozomu

doi:10.1002/hed.21070

Cited by 43 publications

(24 citation statements)

References 15 publications

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“…In the pharmaceutical industry, for example, L-ribose can be used as a building block for drugs against cancers and viral infections. Its most important application is in antiviral Treatment of cancer, in particular chronic myeloid leukemia [3,34,72,76,116] Suppression of thrombus formation and reperfusion injury [4,35,77] Cryoprotectant for mammalian cells and organs [102] Immunosuppressant [36] D-Altrose Synthesis of cyclic carbamates of derived glycosylamines (polymer chemistry) [53,55] D-Arabinose Synthesis of antitumor compounds, such as dehydroamino acid derivatives [22,74,123] Production of D-erythroascorbic acid and oxalic acid [66] D-Gulose Drug-formulation agent and food additive [7] D-Idose Synthesis of cyclic carbamates of derived glycosylamines (polymer chemistry) [53,55] D-Lyxose Synthesis of antitumor and immunostimulatory agents [75,104] D-Psicose…”

Section: Introductionmentioning

confidence: 99%

Enzymes for the biocatalytic production of rare sugars

Beerens

Desmet

Soetaert

2012

Journal of Industrial Microbiology and Biotechnology

168

109

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Carbohydrates are much more than just a source of energy as they also mediate a variety of recognition processes that are central to human health. As such, saccharides can be applied in the food and pharmaceutical industries to stimulate our immune system (e.g., prebiotics), to control diabetes (e.g., low-calorie sweeteners), or as building blocks for anticancer and antiviral drugs (e.g., L: -nucleosides). Unfortunately, only a small number of all possible monosaccharides are found in nature in sufficient amounts to allow their commercial exploitation. Consequently, so-called rare sugars have to be produced by (bio)chemical processes starting from cheap and widely available substrates. Three enzyme classes that can be used for rare sugar production are keto-aldol isomerases, epimerases, and oxidoreductases. In this review, the recent developments in rare sugar production with these biocatalysts are discussed.

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Section: Introductionmentioning

confidence: 99%

Enzymes for the biocatalytic production of rare sugars

Beerens

Desmet

Soetaert

2012

Journal of Industrial Microbiology and Biotechnology

168

109

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“…In recent studies, we reported that d-allose inhibited the growth of head and neck cancer cells by inducing of cell cycle arrest, apoptosis and competition with glucose uptake (16). In addition, d-allose stimulates the overexpression of TRX-interacting protein (TXNIP) and enhances the effects of radiation (17).…”

Section: Introductionmentioning

confidence: 99%

Effects of d-allose in combination with docetaxel in human head and neck cancer cells

Indo

Hoshikawa

Kamitori

et al. 2014

International Journal of Oncology

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Abstract. In this study we investigated the combined effects of docetaxel and d-allose in HSC3 human oral carcinoma cells. The dose enhancement ratios at the 25% survival level were 1.3 and 1.71 for combined treatment with 10 or 25 mM d-allose, respectively. Apoptosis was significantly increased by addition of d-allose. Additionally, a synchronous increase in the G 2 /M-phase population was observed after docetaxel plus d-allose treatment. In vivo experiments revealed that docetaxel plus d-allose was more effective than either agent alone. Thus, d-allose enhanced the anticancer effects of docetaxel, and combined treatment may be useful to achieve clinical efficacy with reduced toxicity.

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“…Recently, increasing attention has been paid to this rare sugar due to its beneficial activities and potential pharmaceutical effects, such as antitumor [65], anticancer [66], anti-inflammatory [67], anti-oxidative [68], antihypertensive [69], cytoprotective [70], and immunosuppressant [71]. L-Rhamnose isomerase (EC 5.3.1.14), ribose-5-phosphate isomerase (EC 5.3.1.6), and galactose-6-phosphate isomerase (EC 5.3.1.26) were reported as potential enzymes for the bioconversion of D-psicose to D-allose [72].…”

Section: Reviewmentioning

confidence: 99%

Biosynthesis of rare hexoses using microorganisms and related enzymes

Li¹,

Gao²,

Nakanishi³

et al. 2013

Beilstein J. Org. Chem.

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SummaryRare sugars, referred to as monosaccharides and their derivatives that rarely exist in nature, can be applied in many areas ranging from foodstuffs to pharmaceutical and nutrition industry, or as starting materials for various natural products and drug candidates. Unfortunately, an important factor restricting the utilization of rare sugars is their limited availability, resulting from limited synthetic methods. Nowadays, microbial and enzymatic transformations have become a very powerful tool in this field. This article reviews the biosynthesis and enzymatic production of rare ketohexoses, aldohexoses and sugar alcohols (hexitols), including D-tagatose, D-psicose, D-sorbose, L-tagatose, L-fructose, 1-deoxy-L-fructose, D-allose, L-glucose, L-talose, D-gulose, L-galactose, L-fucose, allitol, D-talitol, and L-sorbitol. New systems and robust catalysts resulting from advancements in genomics and bioengineering are also discussed.

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Growth inhibition of head and neck carcinomas by D‐allose

Abstract: Our results indicate that D-allose inhibits the growth of head and neck squamous cell carcinoma cells. D-allose has a considerable potential as a new anticancer agent in those patients.

Cited by 43 publications

References 15 publications

Enzymes for the biocatalytic production of rare sugars

Enzymes for the biocatalytic production of rare sugars

Effects of d-allose in combination with docetaxel in human head and neck cancer cells

Biosynthesis of rare hexoses using microorganisms and related enzymes

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