Growth inhibition of Escherichia coli B by nucleoside analogs

Bártová, Markyta; Ryba, Miloš; Jedlicková, Z; Novotný, Ladislav; Hřebabecký, Hubert; Beránek, Jaroslav

doi:10.1135/cccc19832088

Cited by 9 publications

(4 citation statements)

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“…1). The difference in their inhibitory effects is supporting the original findings of different mechanism of action of these compounds (BÁRTOVÁ et al 1983, BERÁNEK and ACTON 1984, VACHÁLKOVÁ et al 1983.…”

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confidence: 77%

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Effect of thioredoxin on the sensitivity of bacteria to chemical damage

Musrati

Kollárová

Labudova

et al. 1999

J. Basic Microbiol.

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The ability of thioredoxin (Trx) to protect cells from chemical damage was determined by comparing the growth of a control strain of Escherichia coli JM101 and isogenic strain transformed with the plasmid pKKTS1 containing the Streptomyces aureofacien thioredoxin gene, in the presence of the nucleoside analogs arabinosylcytosine, 5‐fluorouridine, ftorafur and carcinogen β‐naftylamine. Arabinosylcytosine showed no effect on the growth of either of the two strains. 5‐fluorouridine, ftorafur [1‐((R,S)‐tetrahydrofuran‐2‐yl)‐5‐fluorouracil] and β‐naftylamine demonstrated lower inhibitory effects on the growth of the thioredoxin overproducing strain than on the growth of the control strain. These results suggested that Trx could protect the cells from chemical damage under certain metabolic conditions.

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supporting

confidence: 77%

“…Cells were cultivated for 12 hour at 37 °C on a rotary shaker. After this time the chemical agents were added to the cultures as described by BÁRTOVÁ et al (1983).…”

mentioning

confidence: 99%

Effect of thioredoxin on the sensitivity of bacteria to chemical damage

Musrati

Kollárová

Labudova

et al. 1999

J. Basic Microbiol.

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“…In recent years, some 1,2,4-triazine-5-one derivatives which displayed excellent antibacterial activity [ [8] , [9] , [10] ], antiviral [ 11 ] and antiproliferative effects [ 12 ] were found. For instance, thiadiazolotriazinones [ 13 , 14 ] ( A and B , Fig.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis and antibacterial activity of novel 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives

Hou,

Li,

Yan

et al. 2024

Heliyon

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“…In order to study structure-activity relationships (1)(2)(3)(4)(5), various derivatives of deoxynucleosides were recently synthesized, in particular those incorporating the cancerostatic agents 5-fluorouracil (1,6) and arabinosylcytosine (2,7). Attention was focussed on 5'-deoxy derivatives which are unable to form 5'-phosphate esters, the proposed active forms of both agents (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Structure and conformation of 2′,5′-anhydroarabinosylcytosine: X-ray, ¹H nmr and ¹³C nmr analyses

Birnbaum¹,

Budêšínský²,

Beránek³

1987

Can. J. Chem.

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Crystals of 2',5'-anhydroarabinosylcytosine hemihydrate belong to the monoclinic space group P21. The cell dimensions are a = 9.643(2), b = 10.328(1), c = 10.544(2) A, P = 94.55!1)". X-ray intensity data were measured on a diffractometer and the structure was determined by direct methods. Least-squares refinement, which included all nucleoside hydrogen atoms, converged at R = 0.041 for 2298 observed reflections. The asymmetric unit contains two molecules of the nucleoside and one molecule of water. In both nucleoside molecules, the conformation about the glycosyl bond is anti, with XCN values of 15.5(3) and 26.3(3)", respectively. In the bicyclic sugar moiety, the arabinofuranose rings adopt a C(3')exo/C(2')endo conformation and are highly puckered (7, = 57"). The solution conformation was studied by 'H and I3C nmr spectroscopy. A difference nOe proton nmr spectrum and 3~(~,~) coupling constants reveal an anti conformation in solution, with torsion angles very similar to those obtained from X-ray analysis. A comparison of observed 3J(H,H) coupling constants with those calculated on the basis of a modified Kitrplus equation shows significant differences, probably due to the presence of the bicyclic system. Une comparaison des constantes de couplage 3~( H ,~) observkes avec celles calculCes en se basant sur une Cquation de Karplus modifiee prksente des differences notables qui sont probablement dues i la presence du systkme bicyclique.[Traduit par la revue]

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Growth inhibition of Escherichia coli B by nucleoside analogs

Cited by 9 publications

References 0 publications

Effect of thioredoxin on the sensitivity of bacteria to chemical damage

Effect of thioredoxin on the sensitivity of bacteria to chemical damage

Design, synthesis and antibacterial activity of novel 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives

Structure and conformation of 2′,5′-anhydroarabinosylcytosine: X-ray, ¹H nmr and ¹³C nmr analyses

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Growth inhibition of Escherichia coli B by nucleoside analogs

Cited by 9 publications

References 0 publications

Effect of thioredoxin on the sensitivity of bacteria to chemical damage

Effect of thioredoxin on the sensitivity of bacteria to chemical damage

Design, synthesis and antibacterial activity of novel 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives

Structure and conformation of 2′,5′-anhydroarabinosylcytosine: X-ray, 1H nmr and 13C nmr analyses

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Structure and conformation of 2′,5′-anhydroarabinosylcytosine: X-ray, ¹H nmr and ¹³C nmr analyses