Growth inhibition effect of<i>Rubus coreanus</i>Miquel on<i>Candida albicans</i>

Shin, Ae-Ri; Ohk, Seung‐Ho; Choi, Choong‐Ho; Hong, Suk-Jin

doi:10.11149/jkaoh.2015.39.3.168

Cited by 5 publications

(6 citation statements)

References 13 publications

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“…The statistical analysis was performed with IBM SPSS ver. 21.0 (IBM Co., Armonk, NY, USA). The antibacterial effect were analysed through one-way ANOVA and Tukey's post hoc test at a 0.05 significance level.…”

Section: Discussionmentioning

confidence: 99%

“…Seong et al [20] reported that gallnut extract using methanol showed antifungal activity against C. albicans. Shin et al [21] investigated the antifungal activity of raspberry extract at various concentrations (2,4,8,15,30,60, and 120 mg/ml) against C. albicans and reported that bacterial growth inhibition was shown from the 8 mg/ml concentration of the extract. Choi et al [22] applied Acanthopanax sessiliflorum extract against C. albicans, and the results showed an antibacterial effect at 20 mg/ml while no bacteria were observed at 50 mg/ml.…”

Section: Discussionmentioning

confidence: 99%

“…Although many studies have been conducted to investigate the antibacterial effect of natural-substance extracts on oralcandidiasis-causing bacteria to replace antibiotics for oral candidiasis treatment [20][21][22], no studies have been conducted to investigate the antibacterial effect of Lespedeza cuneata extract on oral candidiasis. Therefore, this study was conducted to investigate the effect of Lespedeza cuneata extract on C. albicans, and to confirm the possibility of using Lespedeza cuneata extract for the treatment and prevention of oral candidiasis.…”

Section: Biomedical Research 2018; 29 (20): 3728-3731mentioning

confidence: 99%

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Antibacterial and antifungal activities of Lespedeza cuneata extract against Candida albicans

Hong¹,

Son²,

Yang³

et al. 2018

biomedicalresearch

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As side effects of chemical antifungal agents has been reported, this study was conducted to confirm the reported antifungal effect of Lespedeza cuneata on Candida albicans (C. albicans), and to investigate the usability of Lespedeza cuneata for the prevention and treatment of oral diseases. Lespedeza cuneata was placed in 80% ethanol at a 5:1 ratio, and was immersed therein for 24 h at a 65°Ϲ dry oven. It was concentrated using a rotary vacuum evaporator after filtration. The concentrated Lespedeza cuneata extract was used after being dried using a -80°Ϲ freeze dryer. The antifungal effect of Lespedeza cuneata extract on C. albicans was investigated using the paper disc method, which presents the bacterial inhibitory area by 1.5, 2.5, 5, 10, and 20 mg/ml concentrations, as well as the colony-forming units (CFUs) method, which confirms the colony formation on the yeast mold (YM) agar medium. The measurement of the clear paper disc circle using a growth inhibitory section showed bacterial inhibition, with 13 mm at 20 mg/ml, 11 mm at 10 mg/ml, and 10 mm at 5 mg/ml. As the concentration of Lespedeza cuneata extract increased, greater bacterial growth inhibition was observed. The survival rate of C. albicans calculated from the CFUs showed more distinct bacterial growth inhibition as the concentration increased. Based on these results, alleviation of the problems and side effects of the use of the existing antibiotics against oral candidiasis was confirmed, as well as the usability of Lespedeza cuneata for the treatment and prevention of oral diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Biomedical Research 2018; 29 (20): 3728-3731mentioning

confidence: 99%

See 1 more Smart Citation

Antibacterial and antifungal activities of Lespedeza cuneata extract against Candida albicans

Hong¹,

Son²,

Yang³

et al. 2018

biomedicalresearch

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“…A. actinomycetemcomitans causes aggressive periodontal disease and colonizes dental plaque 19,20) . C. albicans is a normal flora in the non-pathogenic state, but attaches to oral epithelial cells or dentures of patients with weakened immune systems and causes opportunistic infections and candidiasis 21) . The main components of AGN are coumarin, a lipid-soluble substance, and polysaccharide, a water-soluble substance 22) .…”

Section: Comparison With Previous Studiesmentioning

confidence: 99%

Anti-Oral Microbial Effect of Ethanol Extract of Angelica gigas Nakai

Jeong

2024

J Dent Hyg Sci

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Background: The Korean name for Angelica gigas Nakai (AGN) is Cham-dang-gui, which grows naturally or is cultivated, and its dried roots are used in traditional herbal medicines. The AGN root exert various pharmacological effects. Despite the various pharmacological effects of the AGN root, there are no reports on its anti-oral microbial effects. The purpose of this study was to reveal the anti-oral microbial effect and the microbial and biochemical changes in oral microorganisms according to the concentration of the ethanol extract of AGN (EAGN) root, and to confirm the possibility of using EAGN as a plant-derived functional substance for controlling oral infectious microorganisms. Methods: Disk diffusion test, growth measurement, biofilm formation assay, and measurements of acid production and buffering capacity were performed to confirm the antibacterial effect of EAGN. Results: EAGN showed anti-oral bacterial effects against Streptococcus mutans and Aggregatibacter actinomycetemcomitans at all concentrations, with S. mutans showing a more susceptible effect at concentrations above 5.0 mg/ml and A. actinomycetemcomitans at 3.75 mg/ml. EAGN treatment significantly reduced A. actinomycetemcomitans growth at all concentrations tested. Biofilm formation was significantly reduced at concentrations above 3.75 mg/ml for S. mutans and 2.5 mg/ml for A. actinomycetemcomitans. Acid production in S. mutans and A. actinomycetemcomitans was significantly increased by treatment with EAGN, and the buffering capacities of S. mutans and A. actinomycetemcomitans increased from an EAGN concentration of 3.75 mg/ml and above. Conclusion: EAGN showed anti-oral bacterial effects against both S. mutans and A. actinomycetemcomitans at concentrations above 3.75 mg/ml, which were thought to be related to the inhibition of their growth and biofilm formation. Therefore, EAGN can be used as a safe functional substance derived from medicinal plants owing to its antibacterial effects against S. mutans and A. actinomycetemcomitans.

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“…sobrinus, which were cultured adding plum blossom extracts, using a scanning electron microscope and reported that there was damage to the surface of some bacteria. Shin et al 17) also observed C. albicans, which was cultured adding R. coreanus extracts, using a scanning electron microscope and reported that there was damage to some cells.…”

Section: )mentioning

confidence: 99%

Antimicrobial Effect ofAcanthopanax sessiliflorumFruit Extracts against Selected Oral Bacteria

et al. 2018

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This study aimed to evaluate the antimicrobial effects of Acanthopanax sessiliflorum fruit (ASF; Ogaza) extracts on Streptococcus mutans and Streptococcus sobrinus, which are agents that cause dental caries, and on Streptococcus mitis and Streptococcus salivarius, the microbial flora of the oral cavity. The ASF extracts obtained using 70% ethanol were fractionated in the order of ethyl acetate and n-Butanol, concentrated under reduced pressure, and lyophilized to give powdery solvent extracts. The antimicrobial activity of ASF extracts from each solvent was examined using the disk diffusion method. As a result, only those extracts obtained using an ethyl acetate solvent showed antimicrobial activity. These extracts were selected, and the minimum inhibitory concentration was measured by disk diffusion method at various extract concentrations. Results showed a minimum inhibitory concentration of 32 mg/ml. The viable cell count was measured to confirm the minimum bactericidal concentration. Results showed a minimum bactericidal concentration of 64 mg/ml. In the cytotoxicity test using normal human dermal fibroblast cells, the absorbance value of the test group was similar to that of the control group at 0.64, 1.28, and 6.4 mg/ml. The bacteria and their colonies were examined using a scanning electron microscope. Boundaries between the antimicrobial activity region and non-antimicrobial activity region were observed around the paper disk, which was immersed in the extract with 32 mg/ml concentration. Bacterial colonization was not observed in the area with antimicrobial activity. This finding suggests that ASF extracts can inhibit the growth of some microorganisms in the oral cavity, in addition to the effects of these extracts known to date. In particular, ASF extracts may be used as a preparation for preventing dental caries by adding the extract to the toothpaste or oral mouthwash.

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Growth inhibition effect ofRubus coreanusMiquel onCandida albicans

Cited by 5 publications

References 13 publications

Antibacterial and antifungal activities of Lespedeza cuneata extract against Candida albicans

Antibacterial and antifungal activities of Lespedeza cuneata extract against Candida albicans

Anti-Oral Microbial Effect of Ethanol Extract of Angelica gigas Nakai

Antimicrobial Effect ofAcanthopanax sessiliflorumFruit Extracts against Selected Oral Bacteria

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