Growth inhibition by 8-chloro cyclic AMP of human HT29 colorectal and ZR-75-1 breast carcinoma xenografts is associated with selective modulation of protein kinase A isoenzymes

Ramage, A.D.; Langdon, Simon P.; Ritchie, Alison; Burns, David J.; Miller, William R.

doi:10.1016/0959-8049(95)00190-5

Cited by 21 publications

(11 citation statements)

References 18 publications

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“…5B). These changes, however, were contrary to those reported previously (12,13,39), with no reduction in the ratio of RI to RII subunits (Fig. 5C).…”

Section: Discussioncontrasting

confidence: 85%

Protein Kinase A-Independent Inhibition of Proliferation and Induction of Apoptosis in Human Thyroid Cancer Cells by 8-Cl-Adenosine

Robinson‐White

Hsiao

Leitner

et al. 2008

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…5B). These changes, however, were contrary to those reported previously (12,13,39), with no reduction in the ratio of RI to RII subunits (Fig. 5C).…”

Section: Discussioncontrasting

confidence: 85%

Protein Kinase A-Independent Inhibition of Proliferation and Induction of Apoptosis in Human Thyroid Cancer Cells by 8-Cl-Adenosine

Robinson‐White

Hsiao

Leitner

et al. 2008

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…Elevated intracellular cAMP levels also inhibited tumor growth in mouse xenografts of human colon cancer and breast cancer [48]. These data suggest that the overall effect of cAMP in breast and colon cancer is anti-tumorigenic and is consistent with the observed POPDC1-mediated inhibition of cell migration, proliferation and invasion in various cancer types.…”

Section: The Roles Of Popdc Proteins In Cell Proliferationsupporting

confidence: 80%

The Role of the Popeye Domain Containing Gene Family in Organ Homeostasis

Amunjela

Swan

Brand

2019

Cells

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The Popeye domain containing (POPDC) gene family consists of POPDC1 (also known as BVES), POPDC2 and POPDC3 and encodes a novel class of cyclic adenosine monophosphate (cAMP) effector proteins. Despite first reports of their isolation and initial characterization at the protein level dating back 20 years, only recently major advances in defining their biological functions and disease association have been made. Loss-of-function experiments in mice and zebrafish established an important role in skeletal muscle regeneration, heart rhythm control and stress signaling. Patients suffering from muscular dystrophy and atrioventricular block were found to carry missense and nonsense mutations in either of the three POPDC genes, which suggests an important function in the control of striated muscle homeostasis. However, POPDC genes are also expressed in a number of epithelial cells and function as tumor suppressor genes involved in the control of epithelial structure, tight junction formation and signaling. Suppression of POPDC genes enhances tumor cell proliferation, migration, invasion and metastasis in a variety of human cancers, thus promoting a malignant phenotype. Moreover, downregulation of POPDC1 and POPDC3 expression in different cancer types has been associated with poor prognosis. However, high POPDC3 expression has also been correlated to poor clinical prognosis in head and neck squamous cell carcinoma, suggesting that POPDC3 potentially plays different roles in the progression of different types of cancer. Interestingly, a gain of POPDC1 function in tumor cells inhibits cell proliferation, migration and invasion thereby reducing malignancy. Furthermore, POPDC proteins have been implicated in the control of cell cycle genes and epidermal growth factor and Wnt signaling. Work in tumor cell lines suggest that cyclic nucleotide binding may also be important in epithelial cells. Thus, POPDC proteins have a prominent role in tissue homeostasis and cellular signaling in both epithelia and striated muscle.

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“…Conversely, PKAII is preferentially expressed in normal tissues and seems to be involved in cell growth arrest and differentiation (1,9,10). It has been shown that the selective down-regulation of PKAI by the site-selective cAMP analog 8-Cl-cAMP leads to inhibition of cancer cell growth in a wide variety of cancer cell types in vitro and in vivo (1,4,5,11,12) and is accompanied by inhibition of expression of different oncogenes and growth factors (1,4,5,11). Several studies have also demonstrated that different antisense oligodeoxynucleotides targeting the RI␣ subunit of PKAI expression cause cell growth arrest and differentiation in a wide variety of cancer cell lines (13,14).…”

mentioning

confidence: 99%

Synergistic inhibition of human cancer cell growth by cytotoxic drugs and mixed backbone antisense oligonucleotide targeting protein kinase A

Tortora¹,

Caputo²,

Damiano³

et al. 1997

Proc. Natl. Acad. Sci. U.S.A.

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Growth inhibition by 8-chloro cyclic AMP of human HT29 colorectal and ZR-75-1 breast carcinoma xenografts is associated with selective modulation of protein kinase A isoenzymes

Cited by 21 publications

References 18 publications

Protein Kinase A-Independent Inhibition of Proliferation and Induction of Apoptosis in Human Thyroid Cancer Cells by 8-Cl-Adenosine

Protein Kinase A-Independent Inhibition of Proliferation and Induction of Apoptosis in Human Thyroid Cancer Cells by 8-Cl-Adenosine

The Role of the Popeye Domain Containing Gene Family in Organ Homeostasis

Synergistic inhibition of human cancer cell growth by cytotoxic drugs and mixed backbone antisense oligonucleotide targeting protein kinase A

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