Growth Inhibition and Induction of G1 Phase Cell Cycle Arrest in Human Lung Cancer Cells by a Phenylbutenoid Dimer Isolated from Zingiber cassumunar

Secalonic Acid D induced leukemia cell apoptosis and cell cycle arrest of G1 with involvement of GSK-3β/β-catenin/c-Myc pathway

“…[21][22][23] Cyclin D1, CDK4 and E2F1 are important proteins promoting transition of G 1 to S phase. [24][25][26][27] On the other hand, p27 acts as the inhibitor of transition of G 1 to S phase. [28][29][30] In summary, SAD downregulated the expressions of proteins promoting transition of G 1 /S and upregulated the expressions of proteins inhibiting transition of G 1 /S, which was coincident with PI staining and flow cytometry analysis showing increase of G 1 content.…”

Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies

“…Propolis was shown to inhibit the expression of cyclins B1 and D1, and CDK4, and induce CDKN1A (p21) expression, as indicated in [202]. A novel phenylbutenoid dimer (+/-)-trans-3- (3, 4-dimethoxyphenyl)-4-[(E)-3, 4-dimethoxy-styryl] cyclohex-1-ene (PSC), isolated from Zingiber cassumunar ROXB (Zingiberaceae), inhibited proliferation of various human cancer cells [203]. PSC was shown to induce a cell cycle arrest of human lung cancer A549 cells at the G0/G1 phase, and induce expression of CDKN1A (p21), while reducing expression of cyclins A and D1, CDK-2, and -4, as indicated in [203].…”

“…A novel phenylbutenoid dimer (+/-)-trans-3- (3, 4-dimethoxyphenyl)-4-[(E)-3, 4-dimethoxy-styryl] cyclohex-1-ene (PSC), isolated from Zingiber cassumunar ROXB (Zingiberaceae), inhibited proliferation of various human cancer cells [203]. PSC was shown to induce a cell cycle arrest of human lung cancer A549 cells at the G0/G1 phase, and induce expression of CDKN1A (p21), while reducing expression of cyclins A and D1, CDK-2, and -4, as indicated in [203]. Glycyrrhizin from Japanese herbal supplement ‘Sho-saiko-to’ (also known as minor bupuleurum formula and Xiao Chai Hu Tang in Chinese) was shown to block proliferation of murine malignant melanoma Mel-ret cells in G1 phase by decreasing the expression of CDK-4 and -6 protein levels, as indicated in [204].…”

Suppressive effects of liquid crystal compounds on the growth of the A549 human lung cancer cell line

“…3, 4 and 5). Some low molecular weight compounds, in particular a penylbutenoid dimer which showed a similar level of 50% inhibitory concentration to the LC compounds (10- 30 μM), induces a G 0 /G 1 phase cell cycle arrest as one of the anti-proliferative mechanisms in A549 cells [16]. In addition, Nguyen et al showed that kaempferol, which is one of flavonoid glycons found in diet, inhibits growth and induces apoptosis via activation of MEK-MAPK and c-Jun [17].…”

“…6 and 7). Because mutated Ras protein contributes to the growth of lung cancer cells, G1 phase arrest is thus considered to be one of the important anti-proliferative mechanisms against A549 cell growth as shown in earlier reports [16][17][18][19]. In addition, Yano et al reported that a vitamin E derivative inhibited the mutated K-Ras-ERK pathway and induced G1 arrest and the suppression of proliferation in A549 cells without causing any toxicity in normal cells [19].…”