Growth in vitro of blood vessels from bone marrow of adult chickens

White, Joan; Parshley, Mary S.

doi:10.1002/aja.1000890206

Cited by 34 publications

(4 citation statements)

References 16 publications

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“…These studies suggested the existence of a population of cells in the PB and/or BM capable of generating ECs when cultured under specific conditions [3-5]. However, it was only in 1997 that Asahara et al [6] isolated and characterized CD34+ or VEGFR-2+ cell populations for the first time, derived from PB capable of differentiating into ECs in vitro when plated on fibronectin (FN) and exposed to angiogenic growth factor stimuli, namely vascular endothelial growth factor (VEGF).…”

Section: Reviewmentioning

confidence: 99%

Endothelial progenitor cells and integrins: adhesive needs

Caiado

Dias

2012

Fibrogenesis Tissue Repair

112

105

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In the last decade there have been multiple studies concerning the contribution of endothelial progenitor cells (EPCs) to new vessel formation in different physiological and pathological settings. The process by which EPCs contribute to new vessel formation in adults is termed postnatal vasculogenesis and occurs via four inter-related steps. They must respond to chemoattractant signals and mobilize from the bone marrow to the peripheral blood; home in on sites of new vessel formation; invade and migrate at the same sites; and differentiate into mature endothelial cells (ECs) and/or regulate pre-existing ECs via paracrine or juxtacrine signals. During these four steps, EPCs interact with different physiological compartments, namely bone marrow, peripheral blood, blood vessels and homing tissues. The success of each step depends on the ability of EPCs to interact, adapt and respond to multiple molecular cues. The present review summarizes the interactions between integrins expressed by EPCs and their ligands: extracellular matrix components and cell surface proteins present at sites of postnatal vasculogenesis. The data summarized here indicate that integrins represent a major molecular determinant of EPC function, with different integrin subunits regulating different steps of EPC biology. Specifically, integrin α4β1 is a key regulator of EPC retention and/or mobilization from the bone marrow, while integrins α5β1, α6β1, αvβ3 and αvβ5 are major determinants of EPC homing, invasion, differentiation and paracrine factor production. β2 integrins are the major regulators of EPC transendothelial migration. The relevance of integrins in EPC biology is also demonstrated by many studies that use extracellular matrix-based scaffolds as a clinical tool to improve the vasculogenic functions of EPCs. We propose that targeted and tissue-specific manipulation of EPC integrin-mediated interactions may be crucial to further improve the usage of this cell population as a relevant clinical agent.

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Section: Reviewmentioning

confidence: 99%

Endothelial progenitor cells and integrins: adhesive needs

Caiado

Dias

2012

Fibrogenesis Tissue Repair

112

105

View full text Add to dashboard Cite

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“…Yet, as early as 1932, a description of "Capillary-Like Formations in Tissue Cultures of Leukocytes" was published (Hueper and Russell, 1932). One year later "the development of organized vessels in cultures of blood cells" and in 1950 "in vitro blood vessel" formation from bone marrow of adult chickens were described (Parker, 1933;White and Parshley, 1950). In addition, reports of fallout endothelialization, i.e., endothelialization of grafts by blood-derived cells, have been appearing almost as long as synthetic arterial grafts have been in use (Stump et al, 1963;Mackenzie et al, 1968;Scott et al, 1994;Shi et al, 1994).…”

Section: Adult Hemangioblasts and Vasculogenesismentioning

confidence: 99%

Hemangioblasts, angioblasts, and adult endothelial cell progenitors

Schatteman

Awad

2003

Anat. Rec.

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After decades of speculation, proof of embryonic hemangioblasts finally emerged a few years ago. Surprisingly, at about the same time, evidence for adult hemangioblasts began to appear, and recent single-cell bone marrow transplants have confirmed their existence. Embryonic and adult hemangioblasts appear to share antigenic determinants, including CD34, ACC133, and VEGFR2, although their phenotype may be plastic. They also respond to similar factors, prominent among them vascular endothelial growth factor (VEGF). In the adult, hemangioblasts reside principally in the bone marrow, although they may subsequently leave that niche to reside in nonhematopoietic tissues. A number of studies indicate that these cells or their progeny may be a significant source of endothelial cells in adult pathologic and nonpathologic vascularization, and may participate in vascular repair. In addition to hemangioblasts, a more differentiated source of endothelial cell progenitors may be present in the blood, namely, monocytes or monocytic-like cells. The relative importance of the two cell types in vivo is not clear, though endothelial cells derived from the two sources may not be identical, and hemangioblasts seem to provide a stimulus for differentiation of the monocytes. Treatment with exogenous bone marrow-derived cells can promote neovascularization, accelerate restoration of blood flow to ischemic tissues, and improve cardiac function after infarct. Hence, there is great hope that either alone, in combination with angiogenic factors, or as gene therapy vectors, we can harness these cells to treat ischemic and vascular diseases in the relatively near future. Anat Rec Part A 276A: 13-21, 2004.

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“…In 1932, capillary-like structures were found to appear in cultures of blood-derived leukocytes (Hueper, W.C., et al, 1932), and organized vessels forming in cultures of chicken blood cells were reported in 1933 (Parker, R.C., 1933). Similarly, in 1951, adult chicken bone marrow cells were found to give rise to vessel structures in vitro (White, J.F., et al, 1951), and in 1987, Leu et al (Leu, H.J., et al 1988) found that circulating mononuclear cells give rise to pre-endothelial cells that then mature into cells with endothelial-specific organelles (i.e. Weibel-Palade bodies).…”

Section: Historical Reviewmentioning

confidence: 96%

Hemato-vascular origins of endothelial progenitor cells?

Chao

Hirschi

2010

Microvascular Research

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Numerous studies have suggested the presence of precursor cells in various tissues and organs with potential to differentiate into endothelial and mural cells, and contribute to blood vessel formation in different physiological and pathological circumstances. Although there is still a lack of consensus in the field regarding the origin, and phenotypic and functional characteristics of putative vascular progenitor cell populations, all agree that further studies are needed to fully explore and exploit their great potential as cell therapy for vascular diseases, as modulators of postnatal blood vessel formation, and as disease biomarkers. Herein, we will review the phenotypic and functional characteristics of endothelial progenitor/precursor cell types thought to be derived from the hematopoietic and vascular systems and contribute to postnatal blood vessel formation, and discuss their potential lineage relationships.

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Growth in vitro of blood vessels from bone marrow of adult chickens

Cited by 34 publications

References 16 publications

Endothelial progenitor cells and integrins: adhesive needs

Endothelial progenitor cells and integrins: adhesive needs

Hemangioblasts, angioblasts, and adult endothelial cell progenitors

Hemato-vascular origins of endothelial progenitor cells?

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