Growth hormone treatment in aged patients with comorbidities: A systematic review

Tausendfreund, Olivia; Bidlingmaier, Martin; Martini, Sebastian; Müller, Katharina; Rippl, Michaela; Schilbach, Katharina; Schmidmaier, Ralf; Drey, Michael

doi:10.1016/j.ghir.2024.101584

Cited by 1 publication

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“…Consequently, identifying factors that could enhance or restore GH/IGF-I function would offer additional treatment approaches for multimorbid patients with a coexisting GH resistance. This has the potential to improve the health of great parts of aging population significantly, given the high prevalence of the enumerated diseases above [29,47]. However, the precise contribution of the different diseases to the endocrinologic disturbance remains unclear.…”

Section: Alternative Explanations For An Age-related Igf-i Deficiencymentioning

confidence: 99%

The somatotroph pituitary gland function in high-aged multimorbid hospitalized patients with IGF-I deficiency

Tausendfreund,

Bidlingmaier,

Martini

et al. 2024

Pituitary

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Purpose It is unclear whether the age-related decline in the somatotropic axis stems from a reduced growth hormone (GH) production in the pituitary gland, or from a peripheral origin akin to an acquired GH resistance. With the help of a GHRH/arginine test, high-aged multimorbid hospitalized patients with IGF-I deficiency are to be tested to determine whether there is primarily a pituitary GH deficiency in the sense of a somatopause. Methods Seventeen multimorbid patients (eleven men and six women) with a mean age of 82 years, with IGF-I concentrations below two standard deviations of 30-year-old men and women were identified. Patients suffered from a variety of common age-related stable diseases including coronary artery disease, chronic liver or kidney disease, chronic heart failure as well as acute conditions e.g., urosepsis or endocarditis. To assess the somatotropic axis they underwent a GHRH/arginine test. Results were evaluated using descriptive statistics. Results In average, the peak concentration of GH after stimulation was 14.8 µg/L with a range from 2.76 to 47.4 µg/L. Taking into account both, gender and BMI (with a mean of 26.5 kg/m²) for each participant, the pituitary gland was adequately stimulated in 16 out of the 17 patients. No patient reported common side effects related to the GHRH/arginine test. Conclusion The somatotroph pituitary gland retains its secretory capacity in the advanced aged. Therefore, age does not seem to be the driving pacemaker for the functional decline of the somatotropic axis within the aged population.

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Section: Alternative Explanations For An Age-related Igf-i Deficiencymentioning

confidence: 99%

The somatotroph pituitary gland function in high-aged multimorbid hospitalized patients with IGF-I deficiency

Tausendfreund,

Bidlingmaier,

Martini

et al. 2024

Pituitary

Self Cite

View full text Add to dashboard Cite

show abstract

Growth hormone treatment in aged patients with comorbidities: A systematic review

Cited by 1 publication

References 58 publications

The somatotroph pituitary gland function in high-aged multimorbid hospitalized patients with IGF-I deficiency

The somatotroph pituitary gland function in high-aged multimorbid hospitalized patients with IGF-I deficiency

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