Growth hormone treatment affects plasma LH pulsatile release in women with secondary amenorrhoea

Genazzani, Alessandro D.; Volpogni, Cristina; Pianazzi, Francesco; Montanini, V.; D'Ambrogio, G; Genazzani, Andrea R.

doi:10.1111/j.1365-2265.1993.tb02416.x

Cited by 13 publications

(13 citation statements)

References 19 publications

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“…Unlike in the young (Genazzani et al. ), we did not find a significant stimulatory effect of exogenous GH treatment on pulsatile LH secretion or on gonadal steroid hormone production in the elderly.…”

Section: Discussioncontrasting

confidence: 99%

“…GH administration to women with amenorrhea increases plasma E2 levels, LH pulse frequency, and reduces LH pulse amplitude (Genazzani et al. ). However, based on this study and in nonhuman primates (Wilson ) the change in LH pulsatility was attributed to ovarian feedback activity due to increases in E2 rather than a direct effect on GH/IGF‐1 on gonadotropes.…”

Section: Introductionmentioning

confidence: 99%

“…Not surprisingly, based on the stimulatory effect of GH on SS production in young individuals, GH deficiency and GH resistance results in delayed puberty in boys and girls (Laron 1999), suggesting a permissive relationship between the somatotropic and reproductive axes. GH administration to women with amenorrhea increases plasma E2 levels, LH pulse frequency, and reduces LH pulse amplitude (Genazzani et al 1993). However, based on this study and in nonhuman primates (Wilson 1995) the change in LH pulsatility was attributed to ovarian feedback activity due to increases in E2 rather than a direct effect on GH/ IGF-1 on gonadotropes.…”

Section: Introductionmentioning

confidence: 99%

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Effects of growth hormone administration on luteinizing hormone secretion in healthy older men and women

et al. 2017

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The known interactions between the somatotropic and hypothalamic‐pituitary‐gonadal (HPG) axes have not been well delineated in older individuals. Aging‐associated decline in insulin like growth factor‐1 (IGF‐1) levels has been proposed to play a role in reproductive senescence in animals. However, the effects of GH on LH secretion are unknown in older individuals. Our objective was to determine whether GH modulates LH secretion or levels of sex steroids (SS) in healthy older (ages 65–88 years) men (n = 24) and women (n = 24) with low‐normal plasma IGF‐1 levels. In a double‐masked, placebo‐controlled (n = 24), randomized study, we evaluated the effects of GH (n = 24, 20 μg/kg sc 3×/week) for 26 weeks on nocturnal LH secretory dynamics [(8 pm to 8 am, Q20) min sampling and analyzed by multiparameter deconvolution algorithm]. Indices of LH secretion [frequency, mass per burst, pulsatile production rate, and approximate entropy (ApEn)] and fasting serum IGF‐1, SHBG, and SS (TT, fT, or E2) were measured. At baseline, all indices of LH secretion (frequency, mass per burst, pulsatile production rate) were inversely (P < 0.05) related to IGF‐1, but not to mean nocturnal serum GH concentrations. GH administration for 26 weeks increased serum IGF‐1, but exerted no significant effects on LH secretory dynamics, or concentrations of SSs (TT, fT, or E2) or SHBG in older women or men. These data suggest that GH‐mediated increases in IGF‐1 do not modulate the HPG axis in older individuals.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of growth hormone administration on luteinizing hormone secretion in healthy older men and women

et al. 2017

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“…Other neurohormones, neurosteroids and hormones are also considered to play roles in the pathophysiology of weight loss-related amenorrhea [4]. Changes in the episodic release of luteinizing hormone (LH), growth hormone, prolactin, corticotropin-releasing hormone and allopregnanolone have been reported in patients with hypothalamic amenorrhea [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 98%

Clinical evaluation of patients with weight loss-related amenorrhea: Neuropeptide Y and luteinizing hormone pulsatility

Męczekalski

Genazzani

et al. 2006

Gynecological Endocrinology

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“…On the other hand, GH administration to women with hypothalamic amenorrhea increases LH pulse frequency and reduces LH pulse amplitude but has no effect on the secretory dynamics of FSH 181 . Consequently, short-term GH therapy is used to augment pharmacological ovulation induction in women 20 ' 177 .…”

Section: Ablation and Replacement Studies: How Is Adult Fertility Affmentioning

confidence: 93%

The Impact of the GH-IGF-I Axis on Gonadotropin Secretion: Inferences from Animal Models

Me¹

2001

Journal of Pediatric Endocrinology and Metabolism

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Given the tight, temporal coupling between growth and reproductive development, the idea that a common signal may regulate both adolescent growth and the initiation of puberty has been the focus of much research. Since the ratelimiting step for the onset of puberty is the appropriate hypothalamic secretion of gonadotropin-releasing hormone (GnRH), any factor important for the initiation of puberty must affect GnRH pulsatility. This review examines the hypothesis that GH and/or IGF-I are growth-related signals that regulate the release of GnRH, initiating puberty. By extension, this review also addresses the hypothesis that the GH axis also impacts GnRH and gonadotropin secretion in post-pubertal individuals and, thus, affects the maintenance of fertility in adults. The review examines data from a range of animal models employing a number of different strategies which directly manipulate the activity of either GH or IGF-I. The success of these strategies for producing the desired effects on the GH-IGF-I axis is somewhat variable. Although IGF-I may only play a permissive role in the maintenance of adult fertility, acting at the level of the gonad to increase sensitivity to gonadotropin stimulation, the data indicate that IGF-I is essential for reproductive maturation. However, in addition to its well-documented effects on the gonad, the specific mode of action of IGF-I on the neuroendocrine hypothalamus and GnRH pulsatility remains to be determined.

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Growth hormone treatment affects plasma LH pulsatile release in women with secondary amenorrhoea

Abstract: The present study showed that the administration of GH in amenorrhoeic patients determines the significant changes in episodic LH release in those subjects with normal LH plasma levels and suggests that the action of GH may be dependent upon the ovarian-pituitary feedback action.

Cited by 13 publications

References 19 publications

Effects of growth hormone administration on luteinizing hormone secretion in healthy older men and women

Effects of growth hormone administration on luteinizing hormone secretion in healthy older men and women

Clinical evaluation of patients with weight loss-related amenorrhea: Neuropeptide Y and luteinizing hormone pulsatility

The Impact of the GH-IGF-I Axis on Gonadotropin Secretion: Inferences from Animal Models

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