1991
DOI: 10.1530/acta.0.1240129
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Growth hormone secretion patterns in relation to LH and estradiol secretion throughout normal female puberty

Abstract: Pulsatile growth hormone secretion patterns were studied in relation to luteinizing hormone and estradiol release in 33 healthy (pre)pubertal girls. Plasma GH was determined every 10 min, plasma LH and E2 every hour. Night-time GH release was always higher than daytime GH release. During daytime, all GH secretion parameters, except for the basal GH level, increased significantly from the prepubertal stage to stage B4 before (m\m=-\) the menarche (p=0.05) and decreased thereafter (p=0.05). During night-time, me… Show more

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Cited by 48 publications
(12 citation statements)
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“…The changes in u-GH excretion with age indicated, similar to serum studies, that sex steroids have an influence on hGH secretion [2,3]. The highest concen tration of serum luteinizing hormone concentration has been found in the middle of puberty for both sexes, which might augment hGH secretion via an increase in sex steroid and GH-releasing hormone concentration [26][27][28][29], The influence of sex steroids on u-GH excretion was additionally supported by the fact that adults had higher excretion levels than prepubertal children and that u-GH excretion changed during pubertal matura tion stages (Tanner stages 2-5 with maximum values in stages 3 and 4). The observed peak of night u-GH excre tion in Tanner stage 3 for girls and 4 for boys was in accordance with the peak height velocities in both sexes [19,20], In our study group, girls in Tanner stage 2 had significantly higher u-GH excretion values at night than boys, whereas the opposite was true for Tanner stages 1.…”
Section: Discussionmentioning
confidence: 87%
“…The changes in u-GH excretion with age indicated, similar to serum studies, that sex steroids have an influence on hGH secretion [2,3]. The highest concen tration of serum luteinizing hormone concentration has been found in the middle of puberty for both sexes, which might augment hGH secretion via an increase in sex steroid and GH-releasing hormone concentration [26][27][28][29], The influence of sex steroids on u-GH excretion was additionally supported by the fact that adults had higher excretion levels than prepubertal children and that u-GH excretion changed during pubertal matura tion stages (Tanner stages 2-5 with maximum values in stages 3 and 4). The observed peak of night u-GH excre tion in Tanner stage 3 for girls and 4 for boys was in accordance with the peak height velocities in both sexes [19,20], In our study group, girls in Tanner stage 2 had significantly higher u-GH excretion values at night than boys, whereas the opposite was true for Tanner stages 1.…”
Section: Discussionmentioning
confidence: 87%
“…Given that the hormonal status during menarche and menopause changes drastically 6668, this may suggest respective alterations in the genes’ activity. There are also data about the prolactin-controlled role of TNFRSF11A and TNFSF11 in mammary gland development during pregnancy 69;70.…”
Section: Discussionmentioning
confidence: 99%
“…The close relationship between GH and gonadal steroid levels during the pubertal period suggests that gonadal steroids may stimulate linear growth, in part, by stimulating pituitary GH secretion (Wennink et al 1991). Indeed, both gonadal steroid synthesis and the GH secretory pulse amplitude begin to increase earlier in girls with precocious puberty, and suppression of gonadal steroid secretion by gonadotropin-releasing hormone (GnRH) agonists in these girls also suppresses GH and insulin-like growth factor-I (IGF-I) secretion (Mansfield et al 1988).…”
Section: Puberty: Humansmentioning
confidence: 99%