Growth Hormone Secretion during Sleep

Garnier, Philippe; Raynaud, Françoise; Job, J C

doi:10.1159/000180989

Cited by 12 publications

(2 citation statements)

References 18 publications

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“…First, GH therapy can potentially influence the timing and secretion pattern of GH. External administration increases the body's GH levels, potentially disrupting the natural secretion rhythm [47,48]. This may lead to changes in the timing and duration of deep sleep stages, during which GH is primarily released [49].…”

Section: Influencing Variablesmentioning

confidence: 99%

The Impact of Growth Hormone Therapy on Sleep-Related Health Outcomes in Children with Prader–Willi Syndrome: A Review and Clinical Analysis

Zaffanello,

Pietrobelli,

Piacentini

et al. 2023

JCM

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This literature review of growth hormone (GH) therapy and sleep-related health outcomes in children diagnosed with Prader–Willi syndrome (PWS) assembles evidence for the consequences of sleep deprivation and poor sleep quality: difficulty concentrating and learning at school, behavioral problems, diminished quality of life, and growth impairment. Sleep-disordered breathing (SDB) is another factor that impacts a child’s well-being. We searched the electronic databases Medline PubMed Advanced Search Builder, Scopus, and Web of Science using MeSH terms and text words to retrieve articles on GH deficiency, recombinant human growth hormone (rhGH) therapy, sleep quality, SDB, and PWS in children. The censor date was April 2023. The initial search yielded 351 articles, 23 of which were analyzed for this review. The study findings suggest that while GH may have a role in regulating sleep, the relationship between GH treatment and sleep in patients with PWS is complex and influenced by GH dosage, patient age, and type and severity of respiratory disorders, among other factors. GH therapy can improve lung function, linear growth, and body composition in children with PWS; however, it can also trigger or worsen obstructive sleep apnea or hypoventilation in some. Long-term GH therapy may contribute to adenotonsillar hypertrophy and exacerbate sleep apnea in children with PWS. Finally, GH therapy can improve sleep quality in some patients but it can also cause or worsen SDB in others, leading to diminished sleep quality and overall quality of life. The current evidence suggests that the initial risk of worsening SDB may improve with long-term therapy. In conclusion, rhGH is the standard for managing patients with PWS. Nonetheless, its impact on respiratory function during sleep needs to be thoroughly evaluated. Polysomnography is advisable to assess the need for adenotonsillectomy before initiating rhGH therapy. Close monitoring of sleep disorders in patients with PWS receiving GH therapy is essential to ensure effective and safe treatment.

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Section: Influencing Variablesmentioning

confidence: 99%

The Impact of Growth Hormone Therapy on Sleep-Related Health Outcomes in Children with Prader–Willi Syndrome: A Review and Clinical Analysis

Zaffanello,

Pietrobelli,

Piacentini

et al. 2023

JCM

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“…GH has been extensively studied in male, but less in female, puberty 40–47 . The progressive increment of GH is related to pubertal stage (see T ables 1–4).…”

Section: Growth Hormone Modifications In Female Pubertymentioning

confidence: 99%

Modifications of Growth Hormone Secretion during Female Puberty

Toublanc

1997

Annals of the New York Academy of Sciences

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Growth hormone levels rise steadily through normal puberty, in parallel with the pubertal stages but decline rapidly at the end of puberty (stage V). The general evolution of the secretory profile of GH is parallel to the growth velocity curve. The frequency of GH pulses remains unchanged; however, their amplitude, mean integrated concentrations, area under the curve, and urinary growth hormone are elevated at midpuberty. The main action of GH is to ensure, together with sex steroids, the pubertal growth spurt. However, the role of pubertal GH is not confined to inducing the pubertal growth spurt. It also participates, together with sex steroids, in the acquisition of adult bone mineral density.

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Criteria for Recognition of the Growth-Inefficient Child Who May Respond to Treatment With Growth Hormone

Saggese

Cesaretti²

1989

Arch Pediatr Adolesc Med

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Growth Hormone Secretion during Sleep

Cited by 12 publications

References 18 publications

The Impact of Growth Hormone Therapy on Sleep-Related Health Outcomes in Children with Prader–Willi Syndrome: A Review and Clinical Analysis

The Impact of Growth Hormone Therapy on Sleep-Related Health Outcomes in Children with Prader–Willi Syndrome: A Review and Clinical Analysis

Modifications of Growth Hormone Secretion during Female Puberty

Criteria for Recognition of the Growth-Inefficient Child Who May Respond to Treatment With Growth Hormone

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